A5002023457- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Neuroscience of respiration and sleep
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Intracerebral and Subarachnoid Hemorrhage Research
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Olfactory and Sensory Function Studies
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Neural dynamics and brain function
- Cardiovascular Syncope and Autonomic Disorders
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Vestibular and auditory disorders
- Autoimmune Neurological Disorders and Treatments
- Retinal and Optic Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
Keio University
2016-2025
Keio University Hospital
2015-2025
Shizuoka Red Cross Hospital
2024
Massachusetts General Hospital
2018-2024
Harvard University
2018-2024
St. Luke's International Hospital
2017
In an effort to improve migraine management around the world, International Headache Society (IHS) has here developed a list of practical recommendations for acute pharmacological treatment migraine. The are categorized into optimal and essential, in order provide options all possible settings, including those with limited access medications.
Abstract Background Migraine is associated with cervical artery dissection (CeAD). Calcitonin gene-related peptide (CGRP) a multifunctional neuropeptide vasodilatory effects. The use of anti-CGRP monoclonal antibodies (CGRP mAb) may affect cerebrovascular disease risk; however, no reports have CGRP mAb CeAD. Case presentation and FAERS database analysis We report case vertebral in 39-year-old woman migraine treated galcanezumab. searched the number cases where cerebral were reported as...
Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine brain injury. CSDs disrupt blood-brain barrier (BBB), but mechanisms unknown.
Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond traditional preventive treatment options. However, since CGRPmAb has been available only 2 years in Japan, the difference between good poor responders remains unknown. We aimed investigate clinical characteristics of Japan responded well based on real-world data.We analysed visited Keio University Hospital,...
Abstract Background Clinical characteristics and treatment practice of patients with migraine in Japan real-world setting have not been fully investigated. We conducted a retrospective cohort study using claims database to understand the clinical recent years characterize potentially managed well by current options. Methods Our used data from large maintained JMDC Inc. Patients diagnosis headache or between January 1, 2018, July 31, 2022, were defined as cohort, those prescription treatments...
Cortical spreading depolarization (CSD) induces pro-inflammatory gene expression in brain tissue. However, previous studies assessing the relationship between CSD and inflammation have used invasive methods that directly trigger inflammation. To eliminate injury confounder, we induced CSDs non-invasively through intact skull using optogenetics Thy1-channelrhodopsin-2 transgenic mice. We corroborated our findings by minimally KCl-induced thinned skull. Six over 1 h dramatically increased...
Cortical spreading depression (SD) is an intense depolarization underlying migraine aura. Despite the weight of evidence linking SD to pain phase migraine, controversy remains over a causal role in cephalgia because invasive nature previous induction methods. To overcome this problem, we used novel minimally optogenetic method and examined effect on behavior.Optogenetic was induced as single event or repeatedly every other day for 2 weeks. End points, including periorbital hindpaw mechanical...
Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history headache suffer more from vaccination-induced headaches unknown. We aimed to uncover if develop after COVID-19 mRNA vaccination than healthy controls.We performed a questionnaire survey for nursing staff in our hospital April May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and control, examined occurrence features...
Single episodes of cortical spreading depression (CSD) are believed to cause typical migraine aura, whereas clusters depolarizations have been observed in cerebral ischemia and subarachnoid hemorrhage. We recently demonstrated that the release high-mobility group box 1 (HMGB1) from neurons after CSD a rodent model is dependent on number episodes, such only multiple can induce significant HMGB1 release. Here, we report inductions caused microglial hypertrophy (activation) accompanied by...
To evaluate the efficacy and safety of galcanezumab in patients with migraine a real-world setting Japan.Galcanezumab is first anti-calcitonin gene-related peptide monoclonal antibody approved Japan. best our knowledge, no studies on have been published any international journal from Japan.We retrospectively examined who received three doses between August 2021 February 2022 at Keio University Hospital. We assessed changes monthly days, responder rate, migraine-associated premonitory...
Spreading depolarizations (SDs) are believed to contribute injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However, previous studies used highly invasive methods trigger that can directly cause tissue (eg, topical KCl) confound the interpretation. Here, we tested whether indeed enlarge infarcts when via a novel, noninjurious method using optogenetics.
Background Recent genome-wide association studies have identified transient receptor potential M8 ( TRPM8) as a migraine susceptibility gene. TRPM8 is nonselective cation channel that mediates cool perception. However, its precise role in pathophysiology elusive. Transient V1 (TRPV1) activated by noxious heat. Both and TRPV1 are expressed trigeminal ganglion (TG) neurons. Methods We investigated the functional roles of meningeal inflammation-based model measuring effects facial activation on...
Noninvasive vagus nerve stimulation (nVNS) has recently emerged as a promising therapy for migraine. We previously demonstrated that inhibits cortical spreading depression (CSD), the electrophysiological event underlying migraine aura and triggering headache; however, optimal nVNS paradigm not been defined.Various intensities doses of were tested to improve efficacy on KCl-evoked CSD frequency electrical threshold in validated rat model. Chronic was evaluated by daily delivery four weeks....
The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This aimed to enhance precision prevention multi-factorial, complex diseases, including non-communicable and aging-associated by improving risk stratification prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited City, Japan, between 2012 2015, with follow-up survey. Participants underwent various...