A5103682297- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Nerve injury and regeneration
- Retinal Development and Disorders
- Alzheimer's disease research and treatments
- Lung Cancer Research Studies
- Dialysis and Renal Disease Management
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Innovations in Medical Education
- Lung Cancer Treatments and Mutations
- Cardiac Ischemia and Reperfusion
- Chronic Kidney Disease and Diabetes
- Retinal and Macular Surgery
- Multiple Sclerosis Research Studies
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Ultrasound and Hyperthermia Applications
- Mitochondrial Function and Pathology
- Corneal Surgery and Treatments
- Infectious Encephalopathies and Encephalitis
China Pharmaceutical University
2025
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
New York University Florence
2024
Chengdu University of Traditional Chinese Medicine
2024
Tianjin Medical University
2024
The University of Texas MD Anderson Cancer Center
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2018-2022
Abstract Clinical question What is the comparative effectiveness and safety of commonly used interventional procedures (such as spinal injections ablation procedures) for chronic axial radicular spine pain that not associated with cancer or inflammatory arthropathy? Current practice Chronic a common, potentially disabling complaint, which clinicians often administer procedures. However, clinical guidelines provide inconsistent recommendations their use. Recommendations For people living (≥3...
Abstract Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity gadolinium‐based contrast agents (GBCAs). Nevertheless, there is an extreme shortage highly sensitive renal clearable iron suitable for early damage detection through MRI. Herein, a ultra‐small ferrite nanoprobe (UMFNPs@ZDS) proposed diagnosis via structural functional MRI vivo first time. The comprises core coated with zwitterionic layer,...
The altered expression and function of dopamine receptor D3 (D3R) in patients animal models have been correlated with depression disease severity. However, the morphological alterations biological effects D3R brain after inflammation-induced depressive-like behavior remain elusive. In present study, we ascertained changes regions induced by peripheral administration lipopolysaccharide (LPS). Protein levels proinflammatory cytokines, brain-derived neurotrophic factor (BDNF), extracellular...
Background Diabetic Nephropathy (DN) is one of the microvascular complications diabetes. The potential targets renin-angiotensin-aldosterone system (RAAS) inhibitors for treatment DN need to be explored. Methods GSE96804 and GSE1009 datasets, 729 RAAS inhibitors-related 6,039 DN-related genes were derived from public database overlapped with differentially expressed (DN vs. normal) in obtain candidate targets. Next, key screened via Mendelian randomization analysis expression analysis....
Objective This study was designed to demonstrate the prognostic value of nutritional index (PNI), a reflection systemic immunonutritional status, on long-term survival patients taking epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs). Methods In this retrospective study, eligible advanced NSCLC with sensitive EGFR mutations (exon 19 deletion or L858R in exon 21) were included investigate correlation between PNI and overall (OS). The calculated as 10 x serum albumin...
INTRODUCTION: Anticoagulation therapy in portal vein thrombosis (PVT) patients with cirrhosis is still a matter of debate. Therefore, the aim this work was to evaluate efficacy and safety nadroparin calcium-warfarin sequential (NWS) anticoagulation cirrhotic find an optimal strategy. METHODS: Consecutive PVT who have not received were randomly divided into NWS group (1-month calcium by subcutaneous injection followed 5-month warfarin oral administration) control (no therapy). Overall...
The aims of this study were to investigate the incidence pain in peritoneal dialysis (PD) patients and analyze correlation between quality life.PD who followed up our PD center from March 2016 December 2017 included. Short-Form McGill Pain Questionnaire was used assess status. Depression status, sleep quality, life clinical data also collected.A total 463 included, whom 153 (33.1%) with pain. main cause calcium phosphorus metabolism disorder (51.6%). About 101 (66.0%) had multiple sites...
Neuroinflammation in the nucleus accumbens (NAc) is well known to influence progression of depression. However, molecular mechanisms triggering NAc neuroinflammation depression have not been fully elucidated. Progranulin (PGRN) a multifunctional growth factor that linked innate immune response and inflammation, PGRN plays key role neurodegenerative diseases such as frontotemporal dementia (FTD). Here, purpose this study was validate whether involved neuroinflammation-promoted depressive-like...
The management of vision-threatening retinal diseases remains challenging due to the lack an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for continuous therapeutic agents without need immunosuppressants. In this context, injectable and terminable collagen-alginate composite (CAC) ECT gel, designed with Tet-on pro-caspase-8 system, was developed as safe intraocular platform sustained release glial line-derived neurotrophic factor (GDNF) treat...
To understand the clinicopathological features of patients with primary pulmonary large-cell neuroendocrine carcinoma (LCNEC), including frequency epidermal growth factor receptor (EGFR) mutation, and to explore prognostic factors.We investigated a cohort 50 individuals from our center database who were diagnosed operable LCNEC treated in Sun Yat-sen University Cancer Center. Serum albumin (ALB) neuron-specific enolase (NSE) also collected. Survival curves obtained Kaplan-Meier method,...
To report a case of acute disseminated encephalomyelitis (ADEM) with non-classic MRI findings, diagnosed by autopsy.
We developed ultrasmall catechol-PEG-anchored ferrite nanoparticles for highly sensitive MRA. The probe enables the diagnosis of carotid artery stenosis and subsequent evaluation reperfusion through a single injection.
The management of vision-threatening retinal diseases remains challenging due to the lack an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for continuous therapeutic agents without need immunosuppressants. In this context, injectable and terminable collagen-alginate composite (CAC) ECT gel, designed with Tet-on pro-caspase-8 system, was developed as safe intraocular platform sustained release glial-cell-line-derived neurotrophic factor (GDNF)...
Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning preserve brain function, not yet considered readily achievable clinical settings. One of the most challenging issues that no fine line between stimuli and lethal Here, we show deleterious effect on oligodendrocyte precursor cells (OPCs). We identified Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3),...
High-intensive phototherapy is a therapy recommended American Academy of Pediatrics for neonatal hyperbilirubinemia.The new bule light emitting diode (LED) so far has become an ideal equipment its proper Light intense.As the increasing appliance high-intensive phototherapy,its clinical value and safety are attracting more attention.This review aimed at summarizing efficacy diode(LED) in treatment hyperbilirubinem. Key words: Bule diode; Hyperbilirubinemia; High-intensity phototherapy; Newborn
Objective To study effect of the health resources on overall quality medical students.Methods In three vacations,697 students investigated basic conditions institutions in accordance with level from low to high and self-designed questionnaire.Researchers educated findings.Results Medical got know China better.They deeply realized character work,social position,occupational importance,value professional course,and so on.Conclusion Comprehensive was improved by early clinical practice. Key...
Abstract Background Neuroinflammation in the nucleus accumbens (NAc) is well known to influence progression of depression. However, molecular mechanisms triggering NAc neuroinflammation depression have not been fully elucidated. Progranulin (PGRN) a multifunctional growth factor that linked innate immune response and inflammation, PGRN plays key role neurodegenerative diseases. Here, purpose this study was validate whether involved neuroinflammation-promoted depressive-like phenotype....