A5090051167- Mitochondrial Function and Pathology
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- biodegradable polymer synthesis and properties
- Heme Oxygenase-1 and Carbon Monoxide
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Metabolism and Genetic Disorders
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Redox biology and oxidative stress
- Ferroptosis and cancer prognosis
- Nerve injury and regeneration
- Intracerebral and Subarachnoid Hemorrhage Research
- Forensic Toxicology and Drug Analysis
- Engineering Applied Research
- Phonetics and Phonology Research
- Neonatal Health and Biochemistry
- Cardiovascular Effects of Exercise
- Neurobiology of Language and Bilingualism
- Trace Elements in Health
- Biochemical Acid Research Studies
- Anesthesia and Neurotoxicity Research
Hebei North University
2017-2025
Heilongjiang University
2025
Beijing Hospital
2024
University of Manitoba
2020-2024
Beihang University
2014-2021
Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling correlative data have been generated to support OS theory, a direct cause-and-effect relationship between accumulation of oxidation-mediated damage and aging has not firmly established. Superoxide dismutase 1 (SOD1) primary antioxidant in all cells. It is, however, susceptible oxidation due gains toxic properties This study investigates role oxidized SOD1 derived from amyotrophic lateral sclerosis (ALS)...
Ketogenic diet (KD) has been identified as a potential therapy to enhance recovery after traumatic brain injury (TBI). Diffuse axonal (DAI) is common type of that characterized by delayed disconnection. Previous studies showed demyelination resulting from oligodendrocyte damage contributes degeneration in DAI.The present study tests hypothesis ketone bodies the ketogenic confers protection for myelin and attenuates demyelinated axon DAI.A modified Marmarou's model DAI was induced adult rats....
Abstract: The increasing prevalence of brain injuries resulting in cognitive and motor function impairments poses a substantial global medical challenge. Nerve repair therapies offer promise for addressing injury-related disorders. Ferroptosis, as cell death mechanism associated with oxidative stress inflammation. Certain ferroptosis inhibitors, such iron chelators antioxidants, exhibit therapeutic potential conditions. This review explores the fundamental processes mechanisms that regulate...
Abstract Background Neural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss of stemness after prolonged culture. While compelling correlative data have been generated to support the oxidative stress theory as one primary determinants a direct cause-and-effect relationship between accumulation oxidation-mediated damage NSCs has yet be firmly established. Human SOD1 (hSOD1) is susceptible oxidation. Once...
Preconditioning with inhalative carbon monoxide (CO) at low concentrations provides protection against hypoxic and ischemic insults in the brain heart. The present study aims to test a hypothesis that activation of mitochondrial-derived vesicles (MDVs) is mechanism underlying protective effect CO preconditioning. Here we show preconditioning induced mild oxidative stress activated massive production MDVs. Short exposure concentration monoxide-releasing molecule 2 (CORM-2), donor monoxide,...
Although lexical competition has been ubiquitously observed in spoken word recognition, less known about whether the competitors interfere with recognition of target and how interference is resolved. The present study examined overlapping output would its tested an underestimated hypothesis that domain-general inhibitory control contributes to resolution interference. Specifically, this study, a Visual World Paradigm was used access temporal dynamics activations when participants were moving...
Delayed neurologic sequelae (DNS) are recurrent-transient neuropsychiatric consequences of carbon monoxide (CO) intoxication. Pathologically DNS features damages to the brain white matter. Here we test a hypothesis that direct cytotoxicity CO oligodendrocytes plays role in development DNS. In an vitro model poisoning with releasing molecule-2 (CORM-2) as donor, show CORM-2 at concentrations higher than 200 µM significantly inhibited viability and caused significant death PC12 cells. Similar...
<title>Abstract</title> <bold>Background</bold> Cardiac ischemia-reperfusion (IR) injury in elderly patients leads to severe secondary heart after reperfusion treatment of acute myocardial infarction. However, the mechanisms underlying such remain elusive.<bold>Method</bold> The model mice was established by operation. HL-1 cells were used create hypoxia/ reoxygenation cardiomyocyte model, which treated with over-expression TXNIP, inhibition sFRP3, or inhibitor β-catenin PPAR δ. Mice each...
Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning preserve brain function, not yet considered readily achievable clinical settings. One of the most challenging issues that no fine line between stimuli and lethal Here, we show deleterious effect on oligodendrocyte precursor cells (OPCs). We identified Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3),...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. There no cure currently. The discovery that mutations in the gene SOD1 are cause of ALS marks breakthrough for search effective treatments ALS. an antioxidant highly expressed motor neurons. Human prone to aberrant modifications. Familial ALS-linked variants particularly susceptible Once modified, undergoes conformational changes and becomes misfolded. This study aims determine effect...