Limited penetration of chemotherapeutic drugs through the blood brain barrier (BBB), and increased chemo-resistance glioma cells due to macroautophagy/autophagy, result in high tumor recurrence extremely limited survival patients. Ultrasound-targeted microbubble destruction (UTMD) is a technique transient reversible BBB disruption, which greatly facilitates intracerebral drug delivery. In addition, sonodynamic therapy (SDT) based on ultrasound stimulation sonosensitizer, can be safe...

The green up-conversion emissions centered at the wavelengths of about 534nmand 549nm Er3+ doped silicate glass were recorded, using a 978 nm semiconductorlaser diode (LD) as an excitation source. fluorescence intensity ratio (FIR) greenup-conversion 534nm and in wasstudied function temperature over range 296K-673K. Themaximum sensitivity resolution derived from FIR are approximately 0.0023K-1 0.8K, respectively. It isdemonstrated that prototype optical sensor based on technique fromthe...

Chinese medical universities typically have a high number of students, shortage teachers and limited equipment, as such histology courses been taught using traditional lecture-based formats, with textbooks conventional microscopy. This method, however, has reduced creativity problem-solving skills training in the curriculum. The virtual microscope (VM) system shown to be an effective efficient educational strategy. present study aims describe VM for undergraduates evaluate effects promoting...

ABSTRACT Oligodendrocyte precursor cells (OPCs) undergo a series of energy-consuming developmental events; however, the uptake and trafficking pathways for their energy metabolites remain unknown. In present study, we found that 2-NBDG, fluorescent glucose analog, can be delivered between astrocytes oligodendrocytes through connexin-based gap junction channels but cannot transferred OPCs. Instead, connexin hemichannel-mediated supports OPC proliferation, ethidium bromide or increase 2-NBDG...

A series of uranyl-organic frameworks (UOFs), {[(UO2)2(H2TTHA)(H2O)]·4,4'-bipy·2H2O}n (1), {[(UO2)3(TTHA)(H2O)3]}n (2), and {[(UO2)5(TTHA) (HTTHA)(H2O)3]·H3O}n (3), have been obtained by the hydrothermal reaction uranyl acetate with a flexible hexapodal ligand (1,3,5-triazine-2,4,6-triamine hexaacetic acid, H6TTHA). These compounds exhibited three distinct 3D self-assembly architectures as function pH single-crystal structural analysis, although used was same in each reaction. Surprisingly,...

Tm³⁺/Tb³⁺/Mn²⁺ tridoped phosphate glasses containing different Mn²⁺ ion concentrations were synthesized to explore new white-light-emitting material. Under 355 nm excitation, the CIE coordinates (x=0.328, y=0.337) of Mn0.10 sample doped with 0.10 wt. % are close standard equal energy white-light illumination (x=0.333, y=0.333). The quantum efficiency Mn0.01 is very high (~72.32%). concentration ions has a great effect on emission color, and transitions from Tm³⁺, Tb³⁺ become more intense an...

Microglial activation has been considered as a crucial process in the pathogenesis of neuro-inflammation and psychiatric disorders. Several antipsychotic drugs have shown to display inhibitory effects on microglial vitro, possibly through suppression elevated intracellular calcium (Ca2+) concentration. However exact underlying mechanisms still remain elusive. In this study, we aimed investigate quetiapine (Que), an atypical drug, activation. We utilize chronic cuprizone (CPZ)-induced...

As a major contributor of chemotherapy resistance and malignant recurrence, glioma stem cells (GSCs) have been proposed as target for the treatment gliomas. To evaluate therapeutic potential quetiapine (QUE), an atypical antipsychotic, glioma, we established mouse models with GSCs-initiated orthotopic xenograft gliomas subcutaneous tumors, using GSCs purified from glioblastoma cell line GL261. We investigated antitumor effects QUE on its underlying mechanisms GSCs. Our data demonstrated that...

<title>Abstract</title> Background To explore the impact of using nano-carbon suspension for lymph node tracing on number detected nodes and short-term clinical outcomes in patients undergoing laparoscopic radical resection rectal cancer following neoadjuvant therapy. Methods This study retrospectively analyzed data from 109 who underwent therapy at Weifang People's Hospital January 2020 to December 2022. Of these, 43 received an endoscopic submucosal injection (experimental group), with 22...

To monitor and study the molecular epidemiology, evolution pathogenicity of infectious bronchitis viruses (IBVs) in China recent years further our knowledge IBVs.Thirty-seven IBV isolates were isolated from commercial chickens China. The characterized by RT-PCR, sequencing, typing analyzing entire S1 gene. In addition, 4 selected used to experimentally infect specific pathogen-free their pathogenicity.Three types have been cocirculating chicken flocks years. Unique insertions deletions...

The incidence and mortality of colon cancer is increasing recently. It necessary to identify effective biomarkers for the progression prognosis cancer. To assess potential lncRNA USP30-AS1 (USP30-AS1) in serving as biomarker unearth underlying mechanism.There were 123 patients enrolled. expression was evaluated with PCR tissue cell samples. clinical significance assessed a series statistical methods, while CCK8 Transwell assay conducted estimate its biological effect on cellular processes....

Summary In the present study, we employed high performance liquid chromatography with an amide‐C 16 column to determine eighteen major active ingredients in black tea, including theanine, gallic acid, four purine alkaloids, eight catechins and theaflavins. The method was successfully used analyse two new kinds of teas from leaves Camellia ptilophylla kucha China several other world‐ famous teas. Forty percentage ethanol chosen as extraction solvent for preparing tea extracts. All compounds...

Abstract Developing oligodendrocytes, collectively termed ‘pre‐myelinating oligodendrocytes’ (pre OL s), are vulnerable to hypoxic or ischemic insults. The underlying mechanism of this vulnerability remains unclear. Previously, we showed that Bcl‐2⁄E1B‐19K‐interacting protein 3 ( BNIP 3), a proapoptotic member the Bcl‐2 family proteins, induced neuronal death in caspase‐independent manner stroke. In study, investigated role pre cell by hypoxia ischemia. primary oligodendrocyte progenitor OPC...

The vulnerability of pre-myelinating oligodendrocytes (PreOLs) to ischemic injury plays an important role in the pathogenesis and progression perinatal white matter injury.Although oxidative stress is thought be a major pathogenic mechanism predisposing PreOLs injury, no effective therapies have been identified date.The present study aimed investigate direct protective effects catalpol, potent antioxidant free radical scavenger, on ischemia-induced damage explore whether ERK1/2 signaling...

Yb3+:Er3+ co-doped oxy-fluoride ceramics glass has been prepared. The mechanism of up-conversion emissions about Er3+ was discussed, and the temperature properties green fluorescence between 303 823 K were investigated. results show that sensitivity this sample reaches its maximum value, 0.0047 K−1, when is 383 K, indicating kind can be used as high optical sensor.

Despite great advances, China's postgraduate education faces many problems, for example traditional lecture-based learning (LBL) method provides fewer oppotunities to apply knowledge in a working situation. Task-based (TBL) is an efficient strategy increasing the connections among skills, and competences. This study aimed evaluate effect of modified TBL model on problem-solving abilities medical students China.We allocated 228 first-year at Third Military Medical University into two groups:...

Cocoa tea is a new natural decaffeinated tea. Three types of cocoa (green, oolong and black) were produced their sensory evaluation scores accessed. Main components dissolution rates in ten infusions the three teas analyzed by HPLC spectrophotometry. The comprehensive score evaluations was 85.1, 86.8 94.4, respectively. Upon fermentation contents water extract (46.67%, 41.8% 40%), polyphenols (38.58%, 30.41% 23.6%) total catechins (23.51%, 17.68% 4.02%) green, black decreased gradually,...