A5028525767- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Catalysts for Methane Reforming
- Catalytic Processes in Materials Science
- Cellular transport and secretion
- Catalysis for Biomass Conversion
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Ultrasound and Hyperthermia Applications
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Endoplasmic Reticulum Stress and Disease
- Drug Solubulity and Delivery Systems
- Catalysis and Oxidation Reactions
- Advanced Nanomaterials in Catalysis
- Mosquito-borne diseases and control
- Catalysis and Hydrodesulfurization Studies
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Protein Tyrosine Phosphatases
- Calcium signaling and nucleotide metabolism
- Metastasis and carcinoma case studies
Zhejiang University
2014-2025
The University of Texas MD Anderson Cancer Center
2021-2024
Jilin University of Chemical Technology
2023
Central South University
2012-2022
Jinan University
2021-2022
National University of Singapore
2012-2021
Shaanxi Normal University
2018-2021
Sun Yat-sen University
2018-2021
Second Affiliated Hospital of Zhejiang University
2018-2021
State Key Laboratory of Clean Energy Utilization
2014-2018
Limited penetration of chemotherapeutic drugs through the blood brain barrier (BBB), and increased chemo-resistance glioma cells due to macroautophagy/autophagy, result in high tumor recurrence extremely limited survival patients. Ultrasound-targeted microbubble destruction (UTMD) is a technique transient reversible BBB disruption, which greatly facilitates intracerebral drug delivery. In addition, sonodynamic therapy (SDT) based on ultrasound stimulation sonosensitizer, can be safe...
Mitophagy is an important type of selective autophagy for specific elimination damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation ubiquitin (Ub) plays a critical role in the onset PINK1–Parkin-mediated mitophagy. Phosphatase and tensin homolog (PTEN)-long (PTEN-L) newly identified isoform PTEN, with addition 173 amino acids to its N-terminus. Here we report that PTEN-L novel negative regulator mitophagy via phosphatase activity against...
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, specialized plasma membrane structure. Relatively, the caveolae-independent function less studied. Autophagy process to involve various structures, including autophagosomes, lysosomes, and autolysosomes for degradation intracellular proteins organelles. Currently, in autophagy remains largely elusive. In this study, we demonstrate first time that deficiency promotes both basal inducible...
The antimalarial artemisinin (ART) possesses anticancer activity, but its underlying mechanism remains largely unclear. Using a chemical proteomics approach with artemisinin-based activity probes, we identified over 300 specific ART targets. This reveals an whereby promiscuously targets multiple critical biological pathways and leads to cancer cell death. cytotoxicity of against colorectal (CRC) cells rather than normal colon epithelial is due the elevated capacity heme synthesis in cells....
The fusion of autophagosomes and endosomes/lysosomes, also called autophagosome maturation, ensures the degradation autophagic cargoes. It is an important regulatory step macroautophagy/autophagy process. STX17 key autophagosomal SNARE protein that mediates maturation. Here, we report acetylation regulates its activity degradation. histone acetyltransferase CREBBP/CBP deacetylase HDAC2 specifically regulate STX17. In response to cell starvation MTORC1 inhibition, inactivation CREBBP leads...
Abstract Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and nuclear homology-directed-DNA repair. Here we find GRB2 protects DNA at stalled replication forks from MRE11-mediated degradation in the BRCA2 fork protection axis. Mechanistically, binds inhibits RAD51 ATPase activity to stabilize on forks. In GRB2-depleted cells, PARP inhibitor (PARPi) treatment releases fragments into cytoplasm that activate cGAS–STING pathway trigger...
(−)-Epigallocatechin-3-gallate (EGCG) is the most extensive studied tea polyphenol for its anti-cancer function. In this study, we report a novel mechanism of action EGCG-mediated cell death by identifying critical role lysosomal membrane permeabilization (LMP). First, EGCG-induced in human cancer cells (both HepG2 and HeLa) was found to be caspase-independent accompanied evident cytosolic vacuolization, only observable when were treated serum-free medium. The vacuolization observed...
Abstract Biochar ( BC ), a by‐product from the fast pyrolysis of rice husk, was activated by chemical and physical process. The biochar ABC ) showed graphite‐like morphology had large amount random pores with BET surface area 1058 m 2 /g. properties observed further characterization revealed its feasibility to be used as catalyst support. Syngas methanation probe reaction utilized characterize supported Ru catalyst. catalytic performance Ru/ in superior or comparable conventional carbon AC A...
TP53INP2/DOR (tumor protein p53-inducible nuclear 2) contributes to mammalian macroautophagy/autophagy by carrying deacetylated MAP1LC3/LC3 the cytoplasm. Here, we report that in cytoplasm, TP53INP2 further functions autophagosome biogenesis promoting LC3B-ATG7 interaction. Cytoplasmic expression of N-terminal region TP53INP2, which includes LC3-interacting region, effectively triggered LC3B-PE production and formation. In colocalized early autophagic membrane structures containing ATG14,...
The rapid release of poorly water-soluble drugs from amorphous solid dispersion (ASD) is often associated with the generation supersaturated solution, which provides a strong driving force for precipitation and results in reduced absorption. Precipitation inhibitors, such as polymers surfactants, are usually used to stabilize solution by blocking way kinetic or thermodynamic crystal growth. To evaluate combined effect surfactants on maintaining state itraconazole (ITZ), various were...
SCD1 (stearoyl-coenzyme A desaturase 1) is an endoplasmic reticulum-bound enzyme that catalyzes the formation of first double bond at cis-Δ9 position saturated fatty acids (SFA) to form monounsaturated (MUFA). Increasing evidence indicates autophagy plays important role in regulating lipid metabolism, while little known about whether key enzymes lipogenesis like can regulate autophagy. In this study, we examined using tsc2−/− mouse embryonic fibroblasts (MEFs) possessing constitutively...
Biochar derived from the fast pyrolysis of lauan was activated to develop its pore structure and used as a catalyst support in methanation bio-syngas. The physicochemical properties ruthenium (Ru)/activated biochar (ABC) catalysts were characterized using multiple characterization techniques. effect Ru loading on bio-syngas investigated range ABC supported catalysts. CO conversion low during due H2 content increased upon increasing loading. However, H2/(CO + CO2) ratio by addition...
Glioblastoma multiforme is the most malignant and common brain tumor in adults characterized by poor survival high resistance to chemotherapy radiotherapy. Among new drugs, curcumin, a popular dietary supplement, has proven have potent anticancer effect on variety of cancer cell types; however, it remains difficult achieve satisfactory therapeutic with curcumin using traditional single-drug treatment. In this study, we found that expression miR-326, suppressor microRNA various types,...
Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome response to various stress conditions. Apart from its role the maintenance of homeostasis, autophagy also involves regulation cell cycle progression under nutrient-deprivation However, whether and how regulated especially during mitosis remains largely undefined. Here we show that WIPI2/ATG18B (WD repeat domain, phosphoinositide interacting 2), an autophagy-related (ATG) protein plays critical...
The development of novel antimicrobials is a top priority to address the growing epidemic multidrug-resistant pathogens. Since cationic nonamphiphilic star-shaped are promising molecular scaffolds that provide high charge density in binding anionic bacterial bilayers, this research aimed further increase their membrane perturbation capability by introducing guanidinium groups via enhancing insertion. In particular, computational simulation and experimental investigations revealed our...
Nanoparticles (NPs) have shown potential in cancer therapy, while a single administration conferring satisfactory outcome is still unavailable. To address this issue, the dissolving microneedles (DMNs) were developed to locally deliver functionalized NPs with combined chemotherapy and photothermal therapy (PTT). α-Tocopheryl polyethylene glycol succinate (TPGS)/hyaluronic acid (HA) dual-functionalized PLGA (HD10 NPs) fabricated co-load paclitaxel indocyanine green. HD10 significantly...
Body mass index (BMI) is considered a negative prognostic factor in gastric cancer (GC), but its impact on different types of pathology remains controversial. The purpose this study was to investigate the relationship between BMI and clinicopathology prognosis GC, particularly adenocarcinoma mucinous subtypes. This analyzed 3,081 GC patients who received extensive surgery at Zhejiang Cancer Hospital April 2008 December 2019. Demographic characteristics, tumor survival data were reviewed from...
The epidermal growth factor receptor (EGFR), a ubiquitously expressed tyrosine kinase, is an important in carcinogenesis. Transcriptional intermediary 2 (TIF2), member of the p160 nuclear co-activator gene family, linked to proliferation cancer cells. However, direct interplay between EGFR and receptors remains unclear. Our previous study demonstrated that could directly bind cyclin D1 promoter under regulation oncoprotein latent membrane protein 1 (LMP1), but it also indicated other factors...
Methyl acetate (MA) hydrogenation to ethanol was investigated over SBA-15 supported copper (Cu/SBA-15) catalysts prepared by different methods, including impregnation, deposition precipitation, and homogeneous precipitation. The were characterized means of the Brunauer–Emmett–Teller method, X-ray diffraction, transmission electron microscopy, temperature-programmed reduction photoelectron spectroscopy. Of three catalysts, it found that Cu/SBA-15 catalyst precipitation method has smallest...
A photosensitizer with high phototoxicity, low dark toxicity, and good water solubility is crucial for effective photodynamic therapy (PDT). In this study, a novel class of porphyrin-based water-soluble derivative its isomers, named photohexer-1 (P-1) photohexer-2 (P-2), were synthesized investigated anticancer activity. Both the P-1 P-2, could be utilized as potential sensitizers PDT not only owing to their definite constituents but predominantly due absorption in phototherapeutic window...