A5102728609- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- MXene and MAX Phase Materials
- Ubiquitin and proteasome pathways
- Liver physiology and pathology
- Cellular Mechanics and Interactions
- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Polydiacetylene-based materials and applications
- Nutrition, Health and Food Behavior
- Advanced Glycation End Products research
- Bone health and treatments
- S100 Proteins and Annexins
- biodegradable polymer synthesis and properties
- Cancer Mechanisms and Therapy
- Urologic and reproductive health conditions
- Circular RNAs in diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adenosine and Purinergic Signaling
- Curcumin's Biomedical Applications
Chinese Academy of Sciences
2022-2024
Institute of Applied Ecology
2022-2024
University of Chinese Academy of Sciences
2024
National University of Singapore
2016-2023
First Affiliated Hospital of Bengbu Medical College
2022
Duke-NUS Medical School
2016
Singapore College of Traditional Chinese Medicine
2012
Shenyang Pharmaceutical University
2007
Mitophagy is an important type of selective autophagy for specific elimination damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation ubiquitin (Ub) plays a critical role in the onset PINK1–Parkin-mediated mitophagy. Phosphatase and tensin homolog (PTEN)-long (PTEN-L) newly identified isoform PTEN, with addition 173 amino acids to its N-terminus. Here we report that PTEN-L novel negative regulator mitophagy via phosphatase activity against...
Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded by lysosome response to various stress conditions. Apart from its role the maintenance of homeostasis, autophagy also involves regulation cell cycle progression under nutrient-deprivation However, whether and how regulated especially during mitosis remains largely undefined. Here we show that WIPI2/ATG18B (WD repeat domain, phosphoinositide interacting 2), an autophagy-related (ATG) protein plays critical...
// Lalchhandami Tochhawng 1 , Shuo Deng Ganesan Pugalenthi 3 Alan Prem Kumar 2,4,5,6,7 Kiat Hon Lim 8 Tuan Zea Tan 4 Henry Yang Shing Chuan Hooi Yaw Chong Goh 9,10 Sutherland K. Maciver 11 Shazib Pervaiz 1,12,13,14 and Celestial T. Yap 1,5 Department of Physiology, Yong Loo Lin School Medicine, National University Singapore, Singapore 2 Pharmacology, Bioinformatics Group, Bioscience Core Laboratory, King Abdullah Science Technology (KAUST), Kingdom Saudi Arabia Cancer Institute 5 Institute,...
In gastric cancer (GC), the main subtypes (diffuse and intestinal types) differ in pathological characteristics, with diffuse GC exhibiting early disseminative invasive behaviour. A distinctive feature of is loss intercellular adhesion. Although widely attributed to mutations CDH1 gene encoding E-cadherin, a significant percentage do not harbor mutations. We found that expression actin-modulating cytoskeletal protein, gelsolin, significantly higher diffuse-type compared intestinal-type GCs,...
BP nanosheets caused minimal death to Bacillus tropicus cells but induced most of them enter the VBNC state by inhibiting cellular respiration and metabolic activity, which potentially enhanced antibiotic tolerance.
Long non-coding RNAs (lncRNAs) have become potential therapeutic targets or promising prognostic biomarkers in cancers. However, individual gene does not show sufficient value for clear cell renal carcinoma (ccRCC). Therefore, this study aims to develop a combined lncRNA signature the prognosis of ccRCC.The transcriptome profiling data confirmed ccRCC cases were obtained from The Cancer Genome Atlas (TCGA; https://portal.gdc.cancer.gov/). significance, survival time and diagnostic...
Glyoxal (Gly) and methylglyoxal (MGly), the two most prominent α-dicarbonyls, have drawn much attention because of their significant contribution to secondary organic aerosol brown carbon formation. Current knowledge on abundances particulate Gly MGly in mountainous background atmosphere southern China is very limited. Here, fine aerosols (PM2.5) collected concurrently at summit (1690 m a.s.l.) foot (230 Nanling Mountains during autumn 2018 were analyzed. Unexpectedly higher measured...
Background and Aims: The mTORC1 pathway is known to play a critical role in longevity central regulator for various pathways including cellular, inflammation, metabolic pathways. Age-related functional decline tissue was associated with dysregulation of the pathway. suppression has been shown improve ovarian function mice, but underlying cause remains elusive. We aim investigate common denominator mTOR1, ribosomal protein S6 (rpS6), its reproductive through transient inhibition rps6 axis...