A5019319960- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Cell death mechanisms and regulation
- Photodynamic Therapy Research Studies
- Muscle Physiology and Disorders
- Skin Protection and Aging
- Urinary Bladder and Prostate Research
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Hormonal and reproductive studies
- Dermatologic Treatments and Research
- Pelvic floor disorders treatments
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Biological and pharmacological studies of plants
- Metabolomics and Mass Spectrometry Studies
- Nutrition and Health in Aging
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
KT&G (South Korea)
2024-2025
Korean Society of Ginseng
2021-2024
Ajou University
2011-2022
Suwon Research Institute
2015
Graduate School USA
2015
The dissemination of circulating tumor cells (CTCs) requires the Epithelial-to-Mesenchymal transition (EMT), in which lose their epithelial characteristics and acquire more mesenchymal-like phenotypes. Current isolation CTCs relies on affinity-based approaches reliant expression Epithelial Cell Adhesion Molecule (EpCAM). Here we show EMT-induced breast cancer maintained prolonged mammosphere culture conditions possess increased EMT markers stem cell markers, as well reduced mass size by...
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, specialized plasma membrane structure. Relatively, the caveolae-independent function less studied. Autophagy process to involve various structures, including autophagosomes, lysosomes, and autolysosomes for degradation intracellular proteins organelles. Currently, in autophagy remains largely elusive. In this study, we demonstrate first time that deficiency promotes both basal inducible...
Metabolic rewiring has been recognized as an important feature to the progression of cancer. However, essential components and functions lipid metabolic networks in breast cancer are not fully understood. In this study, we investigated roles altered metabolism malignant phenotype Using a spheroid-induced epithelial-mesenchymal transition (EMT) model, conducted multi-layered lipidomic transcriptomic analysis comprehensively describe lipidome during transformation. A tremendous homeostatic...
<title>Abstract</title> Background <italic>Panax ginseng</italic> C.A. Meyer of the Araliaceae family have various biological activities and pharmacological actions such as anticancer, immunomodulation, anti-inflammatory. In many studies on ginseng, ginseng fruit are still new, effect potential periodontitis in HPDL cells been investigated <italic>in vitro</italic> vivo.</italic> Methods The effects KGC19b a <italic>Porphyromonas gingivalis</italic> lipopolysaccharide (Pg-LPS)-induced model...
TRAIL physically interacts with FADD and RIP1 by pull down (View interaction) TNF Receptor-Associated Death Domain (TRADD) is an essential mediator of receptor-1 (TNFR1)-mediated signaling responsible for recruitment other effector proteins, such as (Receptor Interacting Protein 1) TRAF2 (TNF Factor 2) to the TNFR1 complex [1-4], (Fas-Associated protein Domain) TNFR1-induced secondary complexes [5]. Recruitment these adaptor proteins leads activation MAP kinases NF-κB, well pathways,...
Receptor-interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, exact mechanism by negatively regulates development and progression remains unclear. This report indicates acts as a potent homeostatic proliferation CD4+ CD8+ double-positive (DP) thymocytes. Abnormal RIPK3-deficient DP thymocytes occurs independently well-known role...
Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation of the prostate, which occurs frequently in middle-aged men. In this study, we report effect red ginseng oil (KGC11o) on BPH.The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o 25, 50, 100, 200, and finasteride groups. administered for 8 weeks. The BPH biomarkers, DHT, 5AR1, 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, TGF-β determined serum...
TNF receptor-associated death domain (TRADD) is an essential mediator of receptor signaling, and serves as adaptor to recruit other effectors. TRADD has been shown cycle between the cytoplasm nucleus due its nuclear localization (NLS) export sequences (NES). However, underlying function poorly understood. Here we demonstrate that cytoplasmic translocates DNA double-strand break sites (DSBs) during damage response (DDR). Deficiency or sequestration in cytosol leads accumulation γH2AX-positive...
Here, we investigated whether a mixture of
본 연구에서는 홍삼 비사포닌 분획 추출물(KGC05P0)이 인슐린 민감성 향상과 아디포넥틴의 연관성 및 그에 따른 혈당변화에 미치는 영향을 확인하기 위하여 고인슐린혈증 제2형 당뇨 동물모델에서 간조직의 민감도 활성 단백질, 혈중 포도당 수치, 아디포넥틴 수치의 변화를 살펴보았다. 그 결과 민감성을 향상시키는 단백질 발현 증가와 수치 증가 공복혈당, 농도를 감소시켜 억제 항당뇨 효과를 나타내는 것을 확인하였다. 특히 KGC05P0은 양성대조군인 metformin과 유사한 수준으로 지표들을 개선하여 metformin이 나타낼 수 있는 lactic acidosis와 같은 부작용이 없고 건강한 혈당 유지에 도움을 주는 소재로 사용가능성을 시사하였다. 따라서 KGC05P0는 고인슐린혈증의 당뇨병 모델에서 간기능의 함께 민감성과 관련된 지표들의 활성화를 통해 조절에 효능이 있음을
The purpose of this study was to evaluate the efficacy and safety red ginseng oil (RXGIN) in men with lower urinary tract symptoms.
<p>PDF file - 233K, HL 7702 cells do not express high levels of anti-apoptotic proteins</p>
<p>PDF file - 225K, Pretreatment, but not postreatment of cells with Rg3 has a sensitization effect in TRAIL- induced cell death</p>
<p>PDF file - 2112K, Short term Rg3 treatment is not cytotoxic in HepG2 cells</p>
<p>PDF file - 103K</p>
<p>PDF file - 61K, Rg3-mediated, but not thapsigargin-mediated sensitization of TRAIL is CHOP dependent</p>
<p>PDF file - 765K, Sensitization of Rg3 in TRAIL- induced cell death is dose dependent HepG2 cells</p>
<p>PDF file - 628K, Human normal liver cells (HL 7702) can undergo TRAIL-induced cell death when sensitized by CHX, but not Rg3</p>
<p>PDF file - 628K, Human normal liver cells (HL 7702) can undergo TRAIL-induced cell death when sensitized by CHX, but not Rg3</p>
<p>PDF file - 103K</p>
<p>PDF file - 765K, Sensitization of Rg3 in TRAIL- induced cell death is dose dependent HepG2 cells</p>