A5103215041- Plant Virus Research Studies
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cassava research and cyanide
- Cardiovascular Health and Disease Prevention
- Transgenic Plants and Applications
- RNA Interference and Gene Delivery
- Apelin-related biomedical research
- Inflammasome and immune disorders
- Plant and Fungal Interactions Research
- Pregnancy and preeclampsia studies
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Vitamin D Research Studies
- Renin-Angiotensin System Studies
- Metabolomics and Mass Spectrometry Studies
Putian University
2010-2025
Fujian Medical University
2009-2025
Sun Yat-sen University
2010-2025
Wenzhou Medical University
2023-2025
Tropical Crops Genetic Resources Institute
2024
Chinese Academy of Tropical Agricultural Sciences
2024
Kailuan General Hospital
2013-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Ministry of Agriculture and Rural Affairs
2024
North China University of Science and Technology
2015-2023
Abstract Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. Doublecortin‐like kinase 1 (DCLK1), microtubule‐associated protein kinase, involved in neurogenesis human cancers. However, the role of DCLK1 atherosclerosis remains undefined. In this study, we identified upregulated macrophages atherosclerotic lesions ApoE −/− mice fed an HFD determined that macrophage‐specific deletion attenuates by reducing inflammation mice. Mechanistically, RNA...
The association between vascular stiffening and blood pressure is likely bidirectional. present study was designed to examine temporal relationships among stiffness, progression, hypertension. Asymptomatic Polyvascular Abnormalities Community a community‐based, prospective, long‐term follow‐up observational study. investigation based on the baseline examinations (2010–2011) first measurements (2012–2013) included in A total of 4025 participants were followed for an average 27 months. Of 2153...
Cardiac hypertrophy is an important pathological basis for heart failure. Most physiological activities of cardiomyocytes are regulated by proteins and their post-translational modification. Deubiquitinating enzymes (DUBs) involved in protein stability maintenance closely related to myocardial hypertrophy. In this study, we aimed clarify the regulatory role a DUB, ubiquitin-specific peptidase 28 (USP28), cardiac explore molecular mechanism behind.
Cassava (Manihot esculenta Crantz) leaves, the primary by-product of cassava processing, constitute a significant protein source, accounting for 18 to 38 percent on dry weight basis. Despite their nutritional value, substantial portion these leaves is often discarded post-harvest, resulting in notable resource waste. This study employs metagenomic technology investigate degradation mechanism aiming provide technical reference value-added this by-product. Following 36-hour period natural...
Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency specificity. Since simultaneously enhancing the activity selectivity of lipopeptides is seemingly unsolvable problem for conventional chemistry pharmaceutical approaches, we present biomimetic strategy to construct lipopeptide-based mimics viral architectures infections enhance their antimicrobial efficacy while avoiding side...
To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein cells (HUVECs) its possible mechanism.LDLR-KO were randomly treated with normal saline, liraglutide, or plus a GLP-1R antagonist exendin-9 for four weeks. In parallel, HUVECs cultured ox-LDL alone combined presence absence lectin-like receptor-1(LOX-1) overexpression knockdown....
Abstract Recent studies have shown the crucial role of podocyte injury in development diabetic kidney disease (DKD). Deubiquitinating modification proteins is widely involved occurrence and diseases. Here, we explore regulating mechanism a deubiquitinating enzyme, OTUD5, DKD. RNA-seq analysis indicates significantly decreased expression OTUD5 HG/PA-stimulated podocytes. Podocyte-specific Otud5 knockout exacerbates DKD both type 1 2 mice. Furthermore, AVV9-mediated overexpression podocytes...
Abstract Purpose Vericiguat, a soluble guanylate cyclase (sGC) stimulator, has been demonstrated effective in improving prognosis of patients with heart failure reduced ejection fraction. However, there are limited data concerning the effect vericiguat doxorubicin (DOX)‐induced cardiomyopathy (DIC). In this study, we investigated effects on cardiac structure and function rats DIC as well their potential mechanisms action. Methods were established by intraperitoneal injection DOX (1 mg/kg)...
Antimicrobial peptides show promise in enhancing photothermal therapy, but their application is often limited by the challenge of constructing a delivery system that balances efficacy and safety. Our research demonstrated bactericidal V2C MXene-mediated therapy enhanced concentration-dependent relationship with introduction coating antimicrobial peptide ε-polylysine (EPL). EPL exhibited dual role bacterial binding disrupting membranes, thereby increasing heat transfer efficiency reducing...
Anthracycline antitumor drug doxorubicin (DOX) induces severe cardiotoxicity. Deubiquitinating enzymes (DUBs) are crucial for protein stability and function play a significant role in cardiac pathophysiology. By comparing RNA sequencing datasets conducting functional screening, we determined that Myb-like, SWIRM, MPN domains 1 (MYSM1) is key regulator of DOX-induced In this study, aimed to explore the regulatory mechanisms MYSM1 Genetic knockdown significantly mitigated cardiomyopathy....
Background and aim . Upregulation of prolyl isomerase‐1 (Pin1) protein expression activity was associated with the pathogenesis diabetic vasculopathy through induction endothelial oxidative stress inflammation. Moreover, VDR agonist protects against high glucose‐induced apoptosis inhibition stress. We aimed to explore effects on diabetes‐associated dysfunction role Pin1 in this process. Methods Streptozocin‐induced mice were randomly treated vehicle, (10 μ g/kg/d, i.g., twice a week), or...
Abstract Background The Chinese visceral adiposity index (CVAI), a simple surrogate measure of fat, is significantly associated with cardiovascular disease (CVD) risk in the general population. This study aimed to evaluate association cumulative CVAI (cumCVAI) exposure and its accumulation time course CVD among patients hypertension. Methods prospective involved 15,350 hypertension from Kailuan Study who were evaluated at least three times observation period 2006 2014 (2006–2007, 2010–2011,...