A5100660352- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Health and Risk Factors
- Intergenerational Family Dynamics and Caregiving
- Balance, Gait, and Falls Prevention
- Nerve injury and regeneration
- Chronic Kidney Disease and Diabetes
- Cerebrovascular and Carotid Artery Diseases
- Adenosine and Purinergic Signaling
- Health disparities and outcomes
- Retinal and Optic Conditions
- Optical Imaging and Spectroscopy Techniques
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Acute Kidney Injury Research
- Global Health Care Issues
- Pharmacological Effects of Natural Compounds
- Intensive Care Unit Cognitive Disorders
- Migration, Aging, and Tourism Studies
XinHua Hospital
2014-2025
Shanghai Jiao Tong University
2012-2025
University of California, Los Angeles
2017-2023
Shaanxi Provincial People's Hospital
2022
Shanxi Medical University
2022
Kailuan General Hospital
2016-2021
Yunnan University
2021
North China University of Science and Technology
2016-2020
UCLA Health
2020
Nantong University
2015-2017
Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory effects. However, whether can be reduce the neuroinflammation in Parkinson's disease (PD) little studied. Methods: The study investigated potential effects of vitro vivo, using cell models Lipopolysaccharide (LPS)-simulated BV2 cells animal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD with or without...
Using toponym data, population and night-time light we visualized the development index of Yi, Wa, Zhuang, Naxi, Hani, Dai ethnic groups on ArcGIS as well distribution 25 minorities in study area. First, extracted data area, combined with proportion each group, then obtained group We compared indexes higher indexes. The results show that Yi nationality’s was highest, reaching 28.86 (with two decimal places), lowest (15.22). areas highest minority were concentrated core area development, size...
to explore the association between cerebral small-vessel diseases (CSVDs) and motor symptoms in Parkinson's disease (PD).137 PD patients were recruited into study. Detailed symptoms, including tremor, rigidity, bradykinesia, axial impairment, evaluated using Unified Rating Scale (UPDRS). Non-motor cognition, anxiety, depression, Montreal Cognitive Assessment (MoCA), Hamilton anxiety scale (HAMA), depression (HAMD). Brain MRI was used assess subtypes of CSVDs, lacunes, enlarged perivascular...
Background Clinical assessments of motor symptoms rely on observations and subjective judgments against standardized scales, leading to variability due confounders. Improving inter-rater agreement is essential for effective disease management. Objective We developed an objective rating system Parkinson's (PD) that integrates computer vision (CV) machine learning correct potential discrepancies among raters while providing the basis model performance gain professional acceptance. Methods A...
Aim: To examine gender differences in the effect of intergenerational exchanges on subjective health Chinese rural elderly. Methods: Using data from three waves survey ‘Well‐being Elderly Anhui Province, China’ conducted 2001, 2003 and 2006, respectively, this study uses random logit models for men women separately. Results: While an increase instrumental support children to older people is associated with deterioration men, financial improvement formers' health. Although children, mutual...
Background: Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD). Inflammatory cytokines peripheral immune system can induce neuroinflammation central nervous (CNS). Whether is involved PD unclear. The present study investigated contribution to neuronal loss 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) model PD. Methods: MPTP was intraperitoneally injected into mice generate a model. Mice received clodronate liposomes every 3 days deplete...
Using data from the baseline and follow-up surveys of Well-Being Elderly in Anhui Province, China, conducted 2001, 2003, 2006 by Institute for Population Development Studies Xi’an Jiaotong University, authors use random-effects models to explore gender division intergenerational support elderly rural families. Analyses parents’ children’s suggest that there are differences because roles divisions The analysis shows older mothers receive more returns, which reciprocates their support, while...
The predictive value of cumulative blood pressure (BP) on all-cause mortality and cardiovascular cerebrovascular events (CCE) has hardly been studied. In this prospective cohort study including 52,385 participants from the Kailuan Group who attended three medical examinations without CCE, impact systolic BP (cumSBP) diastolic (cumDBP) CCEs was investigated. For population, mean (standard deviation) age 48.82 (11.77) years which 40,141 (76.6%) were male. follow-up for 3.96 (0.48) 2.98 (0.41)...
L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy associated with emergence L-dopa-induced dyskinesia (LID). In present study, L-dopa and benserazide were loaded by poly (lactic-co-glycolic acid) microspheres (LBM), which can release levodopa in a sustained manner order to continuous stimulate dopaminergic receptors. We investigated role striatal DR1/PKA/P-tau signal transduction molecular event underlying...
The association between blood pressure variability ( BPV ) and the risk of all‐cause mortality cardiovascular diseases CVD is not well understood. Kailuan study a prospective longitudinal cohort on cerebrovascular events factors. In this study, resting was measured at baseline every 2 years from 2006 to 2007. mainly defined as coefficient variation CV ). Hazard ratio HR ), with 95% confidence intervals CI calculated using Cox regression model. Among 52 387 participants, we identified 1817...
Background:Depression is a serious psychiatric disorder that easily causes physical impairments and high suicide rate. Monosialotetrahexosylganglioside crucial ganglioside for the central nervous system has been reported to affect function of brain derived neurotrophic factor system. This study aimed evaluate whether monosialotetrahexosylganglioside antidepressant-like effects.
Human amniotic epithelial (HAE) cells are formed from amnioblasts, separated the epiblast at about eighth day after fertilization. In present study, we attempt to investigate effects of intracerebroventricular transplantation HAE on Parkinson's disease (PD) rats.A PD rat model was induced by 6-OHDA injections. Then rats were transplanted intracerebroventricularly with cells. Apomorphin-induced turns used assess neurobehavioral deficit in rats. Immunofluorescence cytochemistry track survival...
Background: The long-term administration of levodopa (L-dopa), the gold-standard treatment for Parkinson's disease (PD), is irreparably associated with L-dopa-induced dyskinesia (LID), which dramatically affects quality life patients. However, underlying molecular mechanisms how LID exacerbates remain unknown. Neuroinflammation in striatum plays an active role LID. These findings prompt investigation non-neuronal This study will examine effects systemic inflammation development and...
Parkinson's disease (PD) and cardiovascular share many important risk factors, but some associations differ. However, there are no studies that have compared their shared specific factors. The present study aimed to compare factors for PD, coronary events, or ischemic stroke. We prospectively analyzed data from 26,210 participants with lifestyle aged 45-73 years enrolled between 1991 1996. Cox proportional hazards model was used calculate hazard ratios (HRs) 95% confidence intervals (CIs) of...
Abstract Background Current models of levodopa (L ‐dopa)‐induced dyskinesia (LID) are obtained by treating dopamine‐depleted animals with L ‐dopa. However, patients LID receive combination therapies that often include dopamine agonists. Objective Using 6‐hydroxydopamine‐lesioned rats as a model, we aimed to establish whether an adjunct treatment the D2/3 agonist ropinirole impacts on patterns LID‐related neuroplasticity and drug responses. Methods Different regimens ‐dopa monotreatment...
Abstract Background Both hypertension and atherosclerotic plaques are risk factors for cardiovascular disease (CVD). Hypothesis This study aimed to investigate whether the combined effects of carotid increase risks CVD all‐cause mortality. Methods Patients from stroke elderly cohorts Kailuan in China who completed a sonography examination were included study. Participants both underwent physical examinations between 2010 2011 divided into four groups: no with normal blood pressure (n =...
The purpose of this study was to determine the effectiveness systemic administration high dose erythropoietin (EPO) in a 6‑hydroxydopamine (6‑OHDA)‑ induced rat model. Rats were divided into 7 groups. Groups 1‑4 administered daily EPO doses 0; 2,500; 5,000 and 10,000 U/kg via intraperitoneal injection (i.p.) for 5 days. concentration cerebrospinal fluid (CSF) determined by enzyme‑linked immunosorbent assay (ELISA) western blot analysis. then selected subsequent experiments. In group 5, rats...