A5100433658- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Vestibular and auditory disorders
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Hearing, Cochlea, Tinnitus, Genetics
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Barrier Structure and Function Studies
- Inflammation biomarkers and pathways
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Neurological Disorders and Treatments
- Pain Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Spinal Cord Injury Research
- Alzheimer's disease research and treatments
- Magnesium in Health and Disease
University of Chinese Academy of Sciences
2011-2024
Institute of Psychology, Chinese Academy of Sciences
2016-2024
Binzhou University
2014-2024
Binzhou Medical University
2016-2024
Anhui Medical University
2024
First Affiliated Hospital of Anhui Medical University
2024
Nanjing Medical University
2019-2023
Chongqing University
2023
Shanxi Medical University
2006-2022
Qingdao Agricultural University
2022
Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, brain vascular impairment occur within neurovascular units, leading microthrombus formation ultimate death. In this work, a multitarget micelle system is developed simultaneously modulate various cell types involved in these events. Briefly, rapamycin encapsulated...
Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of progression. Poor clinical outcomes are displayed due to irreversible damages caused by early microglia abnormality which triggers development before identical symptoms emerge. Based crosstalk between and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported normalize oxidative inflammatory microenvironment...
Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28–41) CMS induced transient alterations in anhedonia did not persist into adulthood after 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors the forced swimming test and greater number trials to reach criterion set-shifting task, suggesting impaired ability cope with stressors cognitive flexibility allows adaptation dynamic environments...
Abstract Oxidative stress induced by ischemia‐reperfusion causes severe secondary injury in stroke patients. The blood‐brain barrier (BBB) and the challenges targeting core hinder therapeutic effect of drugs. This study introduces a precise biomimetic drug delivery system called SHp‐NM@Edv/RCD (SNM‐NPs), which possesses multiple stepwise capabilities. SNM‐NPs are encapsulated neutrophil membranes (NMs) exhibit (5.16‐fold) on inflammatory microenvironment. modification stroke‐homing peptides...
Abstract Background Pain sensitivity varies across multimodal somatosensory stimuli that can rely on different conductive fibres, which, when damaged, will lead to neuropathies. However, there is limited research examining the characteristics of perceived pain, particularly as affected by ageing process, induced various may small or large fibres. Methods Using heat and pressure fibres separately both younger older adults, this study examined age-associated changes in pain perception...
Stroke, especially ischemic stroke, is an important cause of neurological morbidity and mortality worldwide. Growing evidence suggests that the immune system plays intricate function in pathophysiology stroke. Gelsevirine (Gs), alkaloid from Gelsemium elegans, has been proven to decrease inflammation neuralgia osteoarthritis previously, but its role stroke unknown. In this study, middle cerebral artery occlusion (MCAO) mice model was used evaluate protective effect Gs on administration...
Background: Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD). Inflammatory cytokines peripheral immune system can induce neuroinflammation central nervous (CNS). Whether is involved PD unclear. The present study investigated contribution to neuronal loss 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) model PD. Methods: MPTP was intraperitoneally injected into mice generate a model. Mice received clodronate liposomes every 3 days deplete...
Tanshinone IIA protected against lipopolysaccharide-induced brain injury through the protective effect of blood-brain barrier and suppression oxidant stress inflammatory response.
We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.PCR-restriction fragment length assay performed genotype rs75932628 279 cases diseases patients and 346 control subjects Shanghai Nanjing.There no rs75932628-T variant detected our sample. However, APOEϵ4 shown closely the risk of (Chi-square = 60·288, P 0·000).Our suggested that rare population. Further association...
Early stress is a significant risk factor for the onset of mood disorders such as depression during adulthood. Impairments in cognitive flexibility mediated by prefrontal cortex (PFC) dysfunction are increasingly recognized important etiological and pathological factors development depression. Our previous study demonstrated that social defeat early adolescence produced delayed deficits adult mice. The potential molecular mechanisms underlying these long-term consequences remain unclear. One...
Radiation-induced brain injury is a major adverse event in head and neck tumor treatment, influencing the quality of life for more than 50% patients who undergo radiation therapy experience long-term survival. However, no effective treatments are available these patients, preventative drugs drug-delivery methods must be developed. Based on our results, miR-122-5p was upregulated mouse radiation-induced (RBI) model with nasopharyngeal carcinoma (NPC) received therapy. Intranasal...
Purpose.: To investigate the protective effect of pioglitazone on rat retina after ischemia/reperfusion (I/R) injury and to explore its possible mechanisms.
Background and Purpose- Stroke is a major public health concern worldwide. Although clinical treatments have improved in the acute period after stroke, long-term therapeutics remain limited to physical rehabilitation delayed phase. This study aimed determine whether nNOS (neuronal NO synthase)-CAPON (carboxy-terminal postsynaptic density-95/discs large/zona occludens-1 ligand of nNOS) interaction may serve as new therapeutic target phase for stroke recovery. Methods- Photothrombotic...
According to the microglial hypothesis of schizophrenia, hyperactivation microglia and release proinflammatory cytokines lead neuronal loss, which is highly related onset schizophrenia. Recent studies have demonstrated that fractalkine (CX3CL1) its receptor CX3CR1 modulate function microglia. Thus, present study aimed determine whether plays a role in schizophrenia-related behaviors. A classical animal model social isolation (from postnatal days 21 56), was used induce behaviors C57BL/6J...
Purpose: To explore the relationship between monocyte-to-lymphocyte ratio (MLR) and depression three months after acute ischemic stroke. Patients Methods: From May 2013 to September 2014, 203 patients with stroke were recruited within 7 days post-stroke from Shanghai Ruijin Hospital blood samples collected admission. The Hamilton Depression Scale Clinical Review evaluated at 3 Based on Diagnostic Statistical Manual of Mental Disorders-IV diagnostic criteria, we divided into (PSD) non-PSD...
Accumulating preclinical evidence has uncovered the indispensable role of steroid hormone and their receptors, namely, estrogen receptor (ER) progesterone (PR), in development bone metastases breast cancer. Limited data are available regarding survival difference between different (HR) subgroups, its prognostic significance is uncertain now. Such important for risk stratification needed to formulate specialized regimen metastatic From year diagnosis 2010 2018, 554,585 cancer patients, among...
Summary There is strong evidence of roles the hypothalamus‐pituitary‐adrenal axis and nitric oxide ( NO ) synthase‐ system in depression, but relationship between them unknown. The aim this study, therefore, was to elucidate whether there any correlation corticotropin‐releasing hormone CRH major depressive disorder MDD patients. In 16 outpatients with 18 healthy controls, plasma amino acids citrulline (Cit) arginine (Arg) were determined by high‐performance liquid chromatography, levels...