A5079705999- Alzheimer's disease research and treatments
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomedical Ethics and Regulation
- Neural dynamics and brain function
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Connexins and lens biology
- Folate and B Vitamins Research
- Computational Drug Discovery Methods
- Cholesterol and Lipid Metabolism
- Inflammation biomarkers and pathways
- Cholinesterase and Neurodegenerative Diseases
Ruijin Hospital
2014-2025
Shanghai Jiao Tong University
2013-2024
Huazhong University of Science and Technology
2017-2024
Tongji Hospital
2017-2024
University at Buffalo, State University of New York
2013-2016
Shanghai Institute of Hematology
2013
Previous studies have demonstrated altered metabolites in samples of Alzheimer's disease (AD) patients. However, the sample size from many them is relatively small and are limited. Here we applied a comprehensive platform using ultraperformance liquid chromatography-time-of-flight mass spectrometry gas to analyze plasma AD patients, amnestic mild cognitive impairment (aMCI) normal controls. A biomarker panel consisting six (arachidonic acid, N,N-dimethylglycine, thymine, glutamine, glutamic...
BACKGROUND. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) plays an important role in the clearance of pathological amyloid-β (Aβ) Alzheimer's disease (AD). This study aimed to explore sTREM2 as a central and peripheral predictor conversion from mild cognitive impairment (MCI) AD.
Synapse loss has been considered as a major pathological change in Alzheimer’s disease (AD). It remains unclear about whether and how synapse relates to functional structural connectivity dysfunction AD. We measured synaptic vesicle glycoprotein 2 A (SV2A) binding using 18 F-SynVesT-1 PET evaluate alterations 33 participants with AD, 31 mild cognitive impairment (MCI), 30 controls. examined the correlation between density function. Functional MRI was performed analyze lower regions. tracked...
OBJECTIVE To prospectively evaluate the association between modifiable lifestyle factors and peripheral artery disease (PAD) among individuals with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We included 14,543 T2D from UK Biobank. defined a weighted healthy score using nonsmoking, regular physical activity, high-quality diet, moderate alcohol consumption, optimal waist-to-hip ratio, adequate sleep duration, categorized into unfavorable, intermediate, favorable lifestyles. created...
Abstract INTRODUCTION We aimed to investigate the effect of apolipoprotein E4 ( APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18 F‐florbetapir and PET F‐SynVesT‐1. evaluated influence APOE allele investigated effects genotype associations Alzheimer's disease (AD) biomarkers. The mediation AD biomarkers ε4‐associated loss were analyzed. RESULTS Compared non‐carriers,...
We investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid tau deposition, synaptic density in WMH-connected cortex using multimodal images.
Progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia can be predicted by clinical features and a combination biomarkers may increase the predictive power. In present study, we investigated whether olfactory function plasma neuronal-derived exosome (NDE) Aβ1-42 best predict progression AD dementia.87 MCI patients were enrolled received assessment at 2-year 3-year follow-up reevaluate cognition. meanwhile, 80 healthy controls 88 baseline as well evaluate diagnose...
The main objective of this study was to assess the economic cost Alzheimer's disease (AD) in Shanghai, China, as a pilot for future evaluations. Sixty-seven patients with AD were interviewed, and information AD-related resources used collected from October 2005 September 2006. By retrospective analysis, annual costs calculated expressed Chinese renminbi (RMB). Direct per patient year averaged approximately 8,432 RMB (1,058 USD), indirect 10,568 (1,326 19,001 (2,384 USD) investigation. Total...
Apolipoprotein E (APOE) ε4 allele and sigma-1 receptor (SIGMAR1) c.5C (Q2P) polymorphisms have been acknowledged as risk factors for developing Alzheimer's disease (AD). However, whether these influence the process is unclear. Therefore, two cohorts with a clinical diagnosis of AD were recruited, postmortem confirmed Australian cohort (82 cases) from Brain Bank Network, Chinese detailed assessments recruited through an epidemiology study in Shanghai neurology department outpatients clinic...
<b><i>Background/Aims:</i></b> As a suitable test to screen for Alzheimer's disease (AD) or mild cognitive impairment (MCI), studies validate the Chinese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) are rare. <b><i>Methods:</i></b> A total 151 subjects were recruited and neuropsychological assessments employed. One-way analysis variance Bonferroni correction used compare scores different psychometric scales. Intraclass...
Background and Objective: Alzheimer's disease (AD) has been shown to affect vision in human patients animal models. This study was conducted explore ocular abnormalities the primary visual pathway their relationship with hippocampal atrophy AD mild cognitive impairment (MCI). The aim of this investigate potential value examinations as a biomarker during progression. Methods: Patients MCI ( n = 23) or 17) age-matched cognitively normal controls (NC; 19) were enrolled. Pattern visual-evoked...
α-Synuclein (α-Syn) pathology is present in 30-50 % of Alzheimer's disease (AD) patients, and its interactions with tau proteins may further exacerbate pathological changes AD. However, the specific role different aggregation forms α-Syn progression AD remains unclear. To explore relationship between various types CSF progression. We conducted a retrospective analysis data from Disease Neuroimaging Initiative (ADNI) to examine association forms-Syn0 (no detectable aggregates) Syn1 (α-Syn...
In this work, a near-α titanium alloy with high Si content was developed, and its microstructure controlled into trimodal structure through decreasing-temperature multidirectional forging (DMDF), including lamellar primary α-phase (αl), equiaxed (αe), β-transition (βT). The precipitated silicides presented submicrometer nanometer double scales, the submicron preferentially distributed at grain boundaries or phase nanosilicides within grains. After solid solution 950°C for 40 minutes (HT2),...
Purpose To evaluate the Chinese version of Zarit Burden Interview (ZBI) as an instrument for measuring strain in caregivers elderly people with dementia. Design and Methods The objective present study was to carry out a metric analysis ZBI using cross-sectional study. Patients their completed variety questionnaires, including Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Geriatric Depression Scale (GDS), Hamilton Anxiety (HAMA). Cronbach α coefficient used assess...
We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.PCR-restriction fragment length assay performed genotype rs75932628 279 cases diseases patients and 346 control subjects Shanghai Nanjing.There no rs75932628-T variant detected our sample. However, APOEϵ4 shown closely the risk of (Chi-square = 60·288, P 0·000).Our suggested that rare population. Further association...
The loss of synaptic structure and function has been linked to the cognitive impairment Alzheimer's disease (AD). Dysregulation actin cytoskeleton, which plays a key role in regulating integrity synapses transport proteins, suggested contribute th e pathology AD. In this study, we found that glutamate receptor surface expression frontal cortical neurons were significant diminished familial AD (FAD) model, was correlated with reduction phosphorylated cofilin, protein dynamics filaments....
This study aimed to explore the relationship between 18 single nucleotide polymorphisms (SNPs) and Alzheimer's disease (AD) within southern Chinese population.A total of 420 participants, consisting 215 AD patients 205 sex- age-matched controls, were recruited. The SNaPshot technique polymer chain reaction (PCR) used detect SNPs. Combined with apolipoprotein E (APOE) ε4 allele age at onset, we performed an association analysis these SNPs susceptibility. Furthermore, analyzed SNP-associated...