A5101697926- Antibiotic Resistance in Bacteria
- Food composition and properties
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Enzyme Production and Characterization
- Neuroscience and Neuropharmacology Research
- Carbon and Quantum Dots Applications
- Bacterial Genetics and Biotechnology
- Seaweed-derived Bioactive Compounds
- Microbial Metabolites in Food Biotechnology
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Composting and Vermicomposting Techniques
- Marine Biology and Environmental Chemistry
- Parkinson's Disease Mechanisms and Treatments
- Microplastics and Plastic Pollution
- Anesthesia and Pain Management
- Nanoplatforms for cancer theranostics
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- Pneumocystis jirovecii pneumonia detection and treatment
- Biofuel production and bioconversion
- Escherichia coli research studies
- RNA modifications and cancer
- Extracellular vesicles in disease
Chongqing Medical University
2016-2024
Xiamen University
2016-2024
Huazhong Agricultural University
2023-2024
Nanjing University of Chinese Medicine
2024
Nanjing Drum Tower Hospital
2024
Peking University First Hospital
2024
Peking University
2024
First Affiliated Hospital of Xiamen University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
National Center for Clinical Laboratories
2022
Antimicrobial efficacy, which is central to many aspects of medicine, being rapidly eroded by bacterial resistance. Since new resistance can be induced antimicrobial action, highly lethal agents that reduce burden during infection should help restrict the emergence To improve activity, recent work has focused on toxic reactive oxygen species (ROS) as part bactericidal activity diverse antimicrobials. We report when Escherichia coli was subjected stress and stressor subsequently removed, both...
Quantum dots (QDs) have numerous potential applications in lighting, engineering, and biomedicine. QDs are mainly excreted through the kidney due to their ultrasmall sizes; thus, kidneys target organs of QD toxicity. Here, an organoid screening platform is established used study nephrotoxicity QDs. Organoids templated from monodisperse microfluidic Matrigel droplets found be homogeneous both tissue structure functional recapitulation within a population suitable for quantitative toxic doses....
Significance Finding that pan-tolerance derives from defects in carbohydrate regulation connects stress-mediated lesions with metabolic change, identifies a stable type of tolerance, and demonstrates widely shared death response. Manipulation the response should improve antimicrobial efficacy, preserve beneficial bacteria during use, protect industrial toxic products. Mutations many genes can interfere metabolism; thus, mutation to could be high-probability event. selection tolerance one...
Abstract The success of Mycobacterium tuberculosis (M. ) as a pathogen is largely contributes to its ability manipulate the host immune responses. genome M. encodes multiple immune-modulatory proteins, including several members multi-genic PE_PPE family. Despite intense research, roles PE_PGRS proteins in mycobacterial pathogenesis remain elusive. function PE_PGRS41, characterized by an extended and unique C-terminal domain, was studied. Expression PE_PGRS41 smegmatis , non-pathogenic...
Nanosafety is a major concern for nanotechnology development. Evaluation of the transcriptome and DNA methylome proposed nanosafety assessments. RNA m6A modification plays crucial role in development, disease, cell fate determination through regulating stability decay. Here, since black phosphorus quantum dots (BPQDs), among many other types QDs, increase global level decrease demethylase ALKBH5 lung cells, epitranscriptome taken into consideration first time to evaluate nanosafety. Both...
The main objective of this study was to assess the economic cost Alzheimer's disease (AD) in Shanghai, China, as a pilot for future evaluations. Sixty-seven patients with AD were interviewed, and information AD-related resources used collected from October 2005 September 2006. By retrospective analysis, annual costs calculated expressed Chinese renminbi (RMB). Direct per patient year averaged approximately 8,432 RMB (1,058 USD), indirect 10,568 (1,326 19,001 (2,384 USD) investigation. Total...
Purpose To evaluate the Chinese version of Zarit Burden Interview (ZBI) as an instrument for measuring strain in caregivers elderly people with dementia. Design and Methods The objective present study was to carry out a metric analysis ZBI using cross-sectional study. Patients their completed variety questionnaires, including Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Geriatric Depression Scale (GDS), Hamilton Anxiety (HAMA). Cronbach α coefficient used assess...
Alginate lyase is important in marine alginate degradation, and its enzymatic hydrolysates are excellent antioxidants. Here, we cloned a new lyase, that is, Alg823, from the Gram-negative bacterium Pseudoalteromonas carrageenovora ASY5. The optimal temperature pH of Alg823 were 55°C 8.0, respectively. After 30 min incubation at 50°C, could maintain over 75.0% maximum enzyme activity, suggesting thermostability. recombinant retained more than 80.0% activity after it was treated 6.0–10.0 4°C...
Atherosclerosis (AS) is a chronic inflammatory disease that serves as common pathogenic underpinning for various cardiovascular diseases. Although high circulating branched-chain amino acid (BCAA) levels may represent risk factor AS, it unclear whether dietary BCAA supplementation causes elevated of BCAAs and hence influences the related mechanisms are not well understood. Here, ApoE-deficient mice (ApoE
Widespread antimicrobial resistance encourages repurposing/refining of nonantimicrobial drugs for indications. Gallium nitrate (GaNt), an FDA-approved medication cancer-related hypercalcemia, recently showed good activity against several clinically significant bacteria. However, the mechanism GaNt antibacterial action is still poorly understood. In present work, resistant and tolerant mutants Escherichia coli were sought via multiple rounds killing by GaNt. Multiround-enrichment yielded no...
Black phosphorus quantum dots (BPQDs) are considered to have wide application prospects due their excellent properties. However, there is no study on the effect of BPQDs glucose metabolism. In this study, blood was significantly increased when mice were continuously intragastrically administered 0.1 and 1 mg/kg bw BPQDs. The level elevated from Day 7 28. BPQD exposure also decreased area under curve (AUC) oral tolerance test (OGTT). After exposure, pancreas somatic index increased. Moreover,...
Acupuncture has many advantages in the treatment of certain diseases as opposed to drug therapy. Besides, adenosine been revealed affect cellular progression including proliferation. Therefore, this study aimed at exploring mechanism involving acupuncture stress and fibroblast The fibroblasts from fascia tissues acupoint area (Zusanli) were stimulated by different levels stress, concentrations adenosine, agonist or antagonist A3 receptor (A3 R) investigate effect stimulation, adenosine-A3 R...