A5100687440- Metabolomics and Mass Spectrometry Studies
- Clinical Laboratory Practices and Quality Control
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Hormonal and reproductive studies
- Analytical Chemistry and Chromatography
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism and Genetic Disorders
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Reliability and Agreement in Measurement
- Pesticide Residue Analysis and Safety
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Meta-analysis and systematic reviews
- Atherosclerosis and Cardiovascular Diseases
- Vitamin D Research Studies
- Renal function and acid-base balance
- Adrenal Hormones and Disorders
- Bacterial Identification and Susceptibility Testing
- Nutritional Studies and Diet
- Mass Spectrometry Techniques and Applications
- Potassium and Related Disorders
- Analytical Methods in Pharmaceuticals
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
National Center for Clinical Laboratories
2016-2025
Beijing Hospital
2013-2024
Nanjing University
2024
Hunan Normal University
2024
Ocean University of China
2024
Weatherford College
2023
Huaibei Normal University
2023
Tan Tock Seng Hospital
2022
Shuozhou Central Hospital
2021
Although some polyphenol biomarkers in serum or urine have been identified by untargeted metabolomics and proved to reflect dietary intake, only a few of them validated different studies populations with simple reliable targeted methods. In the present study, method LC/MS/MS for measurement twenty-two samples was established effectively assess habitual intake free-living healthy Chinese subjects. Multivariate logistic regression models were used relationships overweight obesity after...
Quality indicators (QIs) are fundamental tools for enabling users to quantify the quality of all operational processes by comparing it against a defined criterion. QIs data should be collected over time identify, correct, and continuously monitor defects improve performance patient safety identifying implementing effective interventions. According international standard medical laboratories accreditation, laboratory shall establish periodically review evaluate throughout critical aspects...
Background Recent studies have determined that branched-chain (BCAAs) and aromatic (AAAs) amino acids are strongly correlated with obesity atherogenic dyslipidemia strong predictors of diabetes. However, it is not clear if these capable identifying subjects coronary artery disease (CAD), particularly subclinical atherosclerosis who at risk developing CAD. Methods Four hundred seventy two Chinese (272 males 200 females, 42–97 y age) undergoing physical exams were recruited random for...
Background Complete blood count (CBC) reference intervals are important to diagnose diseases, screen donors, and assess overall health. However, current established by older instruments technologies those from American European populations not suitable for Chinese samples due ethnic, dietary, lifestyle differences. The aim of this multicenter collaborative study was establish CBC healthy Han adults. Methods A total 4,642 individuals (2,136 males 2,506 females) were recruited six clinical...
Abstract Objectives Measuring serum 25-hydroxyvitamin D is key in clinical labs, but inter-laboratory variations risk diagnostic errors. This study evaluates the performance of current in-house liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods used top Chinese laboratories and proposes an optimized method for improving 25(OH)D measurement accuracy reliability. Methods Seven pools with different concentrations were prepared sent to 12 participating multiple repeat analysis...
Introduction As global resource demands and environmental challenges intensify, China's vast marine resources present a significant opportunity for sustainable economic development. This study investigates the impact of financial development on high-quality growth in economy across 11 coastal regions from 2011 to 2020. Methods We examine mediation moderation model linking quality China, where increasingly relies support. proposes innovation output industrial structure upgradation as...
Background Serum branched-chain and aromatic amino acids (BCAAs AAAs) have emerged as predictors for the future development of diabetes may aid in risk assessment. However, current methods analysis such biological samples are time consuming. Methods An isotope dilution liquid chromatography tandem mass spectrometry (ID-LC/MS/MS) method serum BCAAs AAAs was developed. The mixed with isotope-labeled BCAA AAA internal standards were extracted acetonitrile, followed by using LC/MS/MS. LC...
Background Reference intervals of Liver function tests are very important for the screening, diagnosis, treatment, and monitoring liver diseases. We aim to establish common reference specifically Chinese adult population. Methods A total 3210 individuals (20–79 years) were enrolled in six representative geographical regions China. Analytes ALT, AST, GGT, ALP, protein, albumin bilirubin measured using three analytical systems mainly used The newly established based on results traceability or...
Several studies have identified a negative association between serum glycine (Gly) levels and metabolic syndrome (MetS). However, this has not been fully established in the elderly. A total of 472 Chinese individuals (272 males 200 females, 70.1 ± 6.6 years old) participated population-based, cross-sectional survey Beijing Hospital. The MetS its components were defined based on 2006 International Diabetes Federation (IDF) standard for Asians. Serum Gly concentration was determined using...
Background Reference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean volume (MPV) and distribution width (PDW) newer hematological parameters, which have been recently reported clinically valuable biomarkers. However, there not many studies that estimated reference these parameters in healthy Chinese Han adults. Objective objectives this study were to establish values PLT [including count, MPV, PDW, platelet‐large cell...
Atherosclerosis (AS) is a chronic inflammatory disease that serves as common pathogenic underpinning for various cardiovascular diseases. Although high circulating branched-chain amino acid (BCAA) levels may represent risk factor AS, it unclear whether dietary BCAA supplementation causes elevated of BCAAs and hence influences the related mechanisms are not well understood. Here, ApoE-deficient mice (ApoE
Simple and precise methods for LDL-cholesterol (LDL-C) HDL-cholesterol (HDL-C) measurements are essential assessment of cardiovascular disease (CVD) risks lipid lipoprotein studies. We report here an ultracentrifugation (UC) HPLC method that requires substantially less specimen volume provides the necessary reliability throughput required by large-volume, high-quality research clinical 2-Mercaptoethanol (ME) was used to dissociate serum [a] (Lp[a]) into apolipoprotein Lp[a] remnant (Lp[a-])...
Branched-chain amino acids (BCAAs), essential for the human body, are mainly obtained from food. High levels of BCAAs in circulation considered as potential markers metabolic-associated fatty liver disease (MAFLD) humans. However, there conflicting reports about effects supplement on MAFLD, and research gut microbiota is not comprehensive. Here, C57BL/6J mice were fed with a high-fat diet or without to elucidate metabolic functions mouse model MAFLD. Compared (HFD) feeding, BCAA...
Background Currently there are no reference intervals (RIs) of sodium (Na), potassium (K), and chlorine (Cl) on Chinese population. Two kinds ion‐selective electrode (ISE) methods were commonly used to determine K, Na, Cl levels in China, the difference between these two needs be evaluated. Methods A total 4,524 healthy participants (1,916 males 2,608 females) 20–79 years old from six cities China selected by strict criteria. Serum CL tested Roche Modular analyzers assigned laboratories....
(1) Background: Chest radiographs are the mainstay of initial radiological investigation in this COVID-19 pandemic. A reliable and readily deployable artificial intelligence (AI) algorithm that detects pneumonia suspects can be useful for screening or triage a hospital setting. This study has few objectives: first, to develop model accurately suspects; second, assess its performance real-world clinical setting; third, by integrating with daily workflow, measure impact on report turn-around...
The Pediatric Reference Intervals in China (PRINCE) was initiated to establish the reference intervals (RIs) of Chinese children, as well make it possible compare variability biochemical markers among countries internationally.