A5005229611- Clinical Laboratory Practices and Quality Control
- Ovarian function and disorders
- Meta-analysis and systematic reviews
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Autoimmune Bullous Skin Diseases
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Obesity and Health Practices
- Reproductive Biology and Fertility
- Hair Growth and Disorders
- Nail Diseases and Treatments
- Hormonal and reproductive studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adrenal Hormones and Disorders
- Bariatric Surgery and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Clinical practice guidelines implementation
- Obesity, Physical Activity, Diet
- Statistical Methods in Clinical Trials
- Cardiac, Anesthesia and Surgical Outcomes
- Ovarian cancer diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
London Clinic
2020-2024
Leeds Teaching Hospitals NHS Trust
2013-2024
Justus-Liebig-Universität Gießen
2022
St James's University Hospital
2013-2020
Leeds General Infirmary
2009-2018
University of Leeds
1995-2017
University of Liverpool
2014
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2014
European Union
2014
University of Prishtina
2014
Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low D levels associated a worse prognosis. The VINDICATE (VitamIN treatIng patients Chronic heArT failurE) study was undertaken establish safety and efficacy of high-dose 25 (OH) D3 (cholecalciferol) supplementation HF due LVSD. We enrolled 229 (179 men) LVSD deficiency (cholecalciferol <50 nmol/l [<20 ng/ml]). Participants were allocated 1 year (4,000 IU...
<h3>Abstract</h3> <b>Objective:</b> To assess if a school based intervention was effective in reducing risk factors for obesity. <b>Design:</b> Group randomised controlled trial. <b>Setting:</b> 10 primary schools Leeds. <b>Participants:</b> 634 children aged 7-11 years. <b>Intervention:</b> Teacher training, modification of meals, and the development action plans targeting curriculum, physical education, tuck shops, playground activities. <b>Main outcome measures:</b> Body mass index, diet,...
BACKGROUND: It has been reported that women with polycystic ovary syndrome (PCOS) benefit from metformin therapy. METHODS: A randomized, placebo-controlled, double-blind study of obese (body mass index >30 kg/m2), oligo-/amenorrhoeic PCOS. Metformin (850 mg) twice daily was compared placebo over 6 months. All received the same advice a dietitian. The primary outcome measures were: (i) change in menstrual cycle; (ii) arthropometric measurements; and (iii) changes endocrine parameters, insulin...
Summary objective Polycystic ovary syndrome (PCOS) is more prevalent in South Asian women residing the UK than Caucasians. Insulin resistance (IR) central to pathogenesis of PCOS, while type 2 diabetes commoner Asians. We aimed determine a possible ethnic difference clinical and biochemical characteristics vs. Caucasian with PCOS. patients design A case‐control cross‐sectional observational study consecutive anovular PCOS (47 Asians, 40 Caucasians) their age‐matched controls (11 Asians 22...
<h3>Abstract</h3> <b>Objectives:</b> To implement a school based health promotion programme aimed at reducing risk factors for obesity and to evaluate the implementation process its effect on school. <b>Design:</b> Data from 10 schools participating in group randomised controlled crossover trial were pooled analysed. <b>Setting:</b> primary Leeds. <b>Participants:</b> 634 children (350 boys 284 girls) aged 7-11 years. <b>Main outcome measures:</b> Response rates questionnaires, teachers9...
BACKGROUND: Metformin appears to improve reproductive function in some women with polycystic ovary syndrome (PCOS). We wished explore the effect of metformin PCOS undergoing IVF. METHODS: A randomized, placebo-controlled, double-blind study was carried out between 2001 and 2004. Patients IVF/ICSI treatment using a long GnRH agonist protocol were randomized receive (MET), 850 mg, or placebo (PLA) tablets twice daily from start down-regulation process until day oocyte collection. The primary...
Quality indicators (QIs) are fundamental tools for enabling users to quantify the quality of all operational processes by comparing it against a defined criterion. QIs data should be collected over time identify, correct, and continuously monitor defects improve performance patient safety identifying implementing effective interventions. According international standard medical laboratories accreditation, laboratory shall establish periodically review evaluate throughout critical aspects...
The British and Irish Porphyria Network guidelines describe best practice in the clinical assessment, investigation management of acute porphyria attacks their complications, including severe with neuropathy. Acute may occur intermittent (AIP), variegate (VP) hereditary coproporphyria (HCP). Aminolaevulinic acid dehydratase deficiency (ADP) is a very rare autosomal recessive porphyria; only six cases substantiated by mutation analysis have yet been described literature. Urinary...
Summary Bariatric surgery can facilitate weight loss and improvement in medical comorbidities. It has a profound impact on nutrition, patients need access to follow‐up aftercare. NICE CG189 Obesity emphasized the importance of minimum 2 years bariatric surgical service recommended that following discharge from service, there should be annual monitoring as part shared care model chronic disease management. NHS England Clinical Reference Group commissioned multi‐professional subgroup, which...
Male hypogonadism (MH) is a common endocrine disorder. However, uncertainties and variations in its diagnosis management exist. There are several current guidelines on testosterone replacement therapy that have been driven predominantly by single disciplines. The Society for Endocrinology commissioned this new guideline to provide all care providers with multidisciplinary approach treating patients MH. This has compiled using expertise from (medical nursing), primary care, clinical...
Immunoassay is unsatisfactory for measuring the testosterone concentrations typically found in women. Bench-top tandem mass spectrometers are a viable alternative technology measurements clinical laboratory.We used stable-isotope dilution liquid chromatography-tandem spectrometry (ID/LC-MS/MS) to measure plasma and serum. The sample volume was 50 muL duplicate; preparation analysis were carried out single tube, batch of 192 tubes analyzed 17.5 h.Intra- interassay imprecision <15% range...
Abstract Background: Immunoassays are used in almost all medical and surgical specialties, but they suffer from interference proteins such as antibodies some patients’ sera. Such interferences usually reported the literature only case reports after introduction of a new assay. Methods: We undertook prospective observational study on 5310 patients for whom common immunoassay tests thyroid-stimulating hormone (TSH) and/or gonadotropins were requested. All TSH gonadotropin results critically...
Objective. The evidence base for child obesity treatment is weak. Children's weight-loss camps, despite their popularity, have not been properly evaluated. This study evaluated the effectiveness of a residential camp program overweight and obese children. Methods. A total 185 children (mean age: 13.9 years) enrolled in 1 4 consecutive programs between 1999 2002 (intervention group) were compared with 94 similar ages who attendees, ie, 38 56 normal-weight intervention group attended 6-week...
To prove the clinical usefulness of cortisol measurements in saliva for exact assessment a patient's corticoid status under therapeutic hormone substitution, we measured simultaneously total serum and non-protein-bound after administration different forms hydrocortisone (cortisol) eight cortisol-suppressed, healthy male volunteers. The intravenous oral 20 mg exceeds binding capacity corticosteroid-binding globulin (CBG), leading to an increase ratio between salivary at higher concentrations...
The relationship between hidradenitis suppurativa (HS) and hyperandrogenism is largely based on the finding of an increased free androgen index due to a low sex hormone binding globulin (SHBG). As SHBG now believed be regulated by factors that influence body weight, previous studies were not controlled for we have re-evaluated status female patients with HS. We studied endocrine 66 women Twenty-three had acne, 23 significantly obese (body mass index: BMI > 30). There was no obesity disease...
Over the last decade, advances in treatment for patients sustaining an acute myocardial infarction (AMI) have reduced mortality rates. We aimed to assess whether with diabetes mellitus (DM) derived similar benefits as without DM.We compared characteristics, management, and survival of DM who sustained AMI 1995 (n = 1762) a second group 2003 1642). All were followed up 18 months or until death. Between prevalence increased from 12.5 16.6% (P < 0.001). Involvement cardiologists, provision...