A5039017398- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Pancreatitis Pathology and Treatment
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Gestational Diabetes Research and Management
- Hormonal and reproductive studies
- Diabetes and associated disorders
Dian Diagnostics (China)
2019-2024
Abstract Objectives Measuring serum 25-hydroxyvitamin D is key in clinical labs, but inter-laboratory variations risk diagnostic errors. This study evaluates the performance of current in-house liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods used top Chinese laboratories and proposes an optimized method for improving 25(OH)D measurement accuracy reliability. Methods Seven pools with different concentrations were prepared sent to 12 participating multiple repeat analysis...
Impaired bile acid (BA) metabolism has been associated with the progression of type 2 diabetes (T2D). However, contribution BAs to pathogenesis latent autoimmune in adults (LADA) remains unclear. This study was aimed at investigating association serum different types and analyzing its correlation main clinical laboratory parameters. Patients LADA, patients T2D, healthy controls (HCs) were enrolled. Serum BA profiles inflammatory cytokines measured. The species indicators assessed by...
Vitamins are classified as either fat-soluble (vitamins A, D, E, K) or water-soluble B and vitamin C). Traditional methods of immunoassay have only been developed for vitamins D,B6, B9 B12. However, they cannot distinguish between subtypes such D2, D3 associated epi isomers (which has higher leveks in infants),giving false positive negative results. Mass spectrometry become a gold standard method small molecule analysis biological samples with its advantages speed,resolution,sensitivity...