A5100640149- Clinical Laboratory Practices and Quality Control
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Reliability and Agreement in Measurement
- Hepatitis C virus research
- Meta-analysis and systematic reviews
- Immune Cell Function and Interaction
- Seaweed-derived Bioactive Compounds
- Statistical Methods in Clinical Trials
- HIV Research and Treatment
- Hemodynamic Monitoring and Therapy
- Blood groups and transfusion
- Single-cell and spatial transcriptomics
- Marine Sponges and Natural Products
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Orthopedic Surgery and Rehabilitation
- Statistical Methods in Epidemiology
- Immune cells in cancer
- Psoriasis: Treatment and Pathogenesis
- Lung Cancer Research Studies
- Animal Virus Infections Studies
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
China Medical University
2013-2025
First Hospital of China Medical University
2010-2025
Second Affiliated Hospital of Nanjing Medical University
2024
Wenzhou Medical University
2015-2023
Shandong Tumor Hospital
2023
Shandong First Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tibet Autonomous Region People's Hospital
2014-2016
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2007
Background Complete blood count (CBC) reference intervals are important to diagnose diseases, screen donors, and assess overall health. However, current established by older instruments technologies those from American European populations not suitable for Chinese samples due ethnic, dietary, lifestyle differences. The aim of this multicenter collaborative study was establish CBC healthy Han adults. Methods A total 4,642 individuals (2,136 males 2,506 females) were recruited six clinical...
Nine new chromane-type meroterpenoids, including the rare nor-meroterpenoid sargasilol A (1) and eight meroditerpenoids sargasilols B–I (2–9), were isolated from a China Sea collection of brown alga Sargassum siliquastrum, together with six known analogues (10–15). The structures chromanes identified by extensive spectroscopic analysis comparison previously reported data. Compounds 1–3 6–15 exhibited inhibition against LPS-induced NO production in BV-2 microglial cells, 1, shorter carbon...
Background Reference intervals of Liver function tests are very important for the screening, diagnosis, treatment, and monitoring liver diseases. We aim to establish common reference specifically Chinese adult population. Methods A total 3210 individuals (20–79 years) were enrolled in six representative geographical regions China. Analytes ALT, AST, GGT, ALP, protein, albumin bilirubin measured using three analytical systems mainly used The newly established based on results traceability or...
Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated with liver diseases. But because of population heterogeneity, different races would causative polymorphisms. Therefore, in this study, we included Chinese Tibetans Uygurs to examine the roles these genes on HBV natural clearance. A total 1341 subjects including 908 433 were recruited. Seven single nucleotide polymorphisms (SNP) genotyped. HLA-DP/DQ clearance both ethnicities (Tibetans, rs3077,...
Four new xenicanes, namely 4α-hydroxyisodictyohemiacetal (1), 4α-hydroxyisodictyoacetal (2), 13,18-diacetoxy-4-hydroxyisodictyo-19-al (3), and 4α-hydroxypachylactone (8), were isolated from a Chinese collection of the brown alga Dictyota plectens, along with four known analogues (4–7). The structures diterpenes determined by extensive spectroscopic data analysis. All compounds evaluated for their antiviral activities against human immunodeficiency virus type 1 (HIV-1) highly pathogenic avian...
Background Reference intervals (RIs) play an important role in clinical decision-making. However, due to the time, labor, and financial costs involved establishing RIs using direct means, use of indirect methods, based on big data previously obtained from laboratories, is getting increasing attention. Different techniques combined with different transformation methods outlier removal might cause differences calculation RIs. there are few systematic evaluations this. Objective This study used...
A large number of people undergo annual health checkup but accurate laboratory criterion for evaluating their status is limited. The present study determined biological variation (BV) and derived parameters common analytes in order to accurately evaluate the test results healthcare population.A total 43 healthy individuals who had regular once a year six consecutive years, were enrolled using physical, electrocardiogram, ultrasonography laboratory. BV data parameters, such as reference...
The Pediatric Reference Intervals in China (PRINCE) was initiated to establish the reference intervals (RIs) of Chinese children, as well make it possible compare variability biochemical markers among countries internationally.
Pediatric Reference Intervals in China (PRINCE) is a nationwide initiative that aims to establish and validate harmonized reference intervals (RIs) for Chinese children adolescents, which 15,150 healthy volunteers aged up 20 years were recruited from 11 centers RIs 7,557 adolescents enrolled 21 RIs.The complete blood cell counts (CBC) of venous whole measured by hematology analyzers through Sysmex systems different centers. Age- sex-specific calculated according the guidelines.Unlike adults...
With the increasing demand and application of lymphocyte subsets detection in clinical laboratories, different single-platform flow cytometer (FCM) systems have been developed. There is an urgent need to establish reference intervals (RIs) for FCMs transferring them from one FCM system another provides a much more feasible convenient approach. This study aimed explore transferability RIs across cytometry platforms.
Objective: To explore correlations between mRNA (hA3G, hA3F, and hA3B) levels CD4+ T-cell counts HIV-1 viral loads to evaluate their respective roles in disease progression. Methods: Real-time polymerase chain reaction was used quantify the of hA3G, hA3B, hA3F peripheral blood mononuclear cells from slow progress patients (SP), asymptomatic HIV-infected (AS), AIDS patients, HIV-negative controls. Results: The hA3G hA3B correlated positively with (r = 0.436, P 0.002, r 0.334, 0.025),...
Background Serum total N-terminal propeptide of type I collagen (P1NP) and serum C-terminal telopeptide (CTX) are used as reference analytes bone turnover in clinical application. Biological variation is important for application these biomarkers. However, the biological data biomarkers not consistent. The present study determined variations P1NP CTX their confidence intervals China using electrochemiluminescence. Methods We collected samples from 25 healthy individuals (17 women 8 men,...
Background The aim of our study was to assess two tumor markers, carbohydrate antigen 724 ( CA 724) and neuron‐specific enolase NSE ), in 20 healthy individuals. Then, we determined their average intra‐ inter‐individual biological variations CV I G ). Methods Blood samples were taken at weekly intervals for five weeks from subjects through a detailed questionnaire physical examination. These stored −80°C analyzed single run duplicate. We calculated the variations, reference change value RCV...
Abstract Background Reference intervals (RIs) transference can expand the applicability of established RIs. However, study on methodology is insufficient, and RIs validation based small samples cannot adequately identify transferred risk under complex situations. This aimed to find appropriate conditions ensure effect transference. Methods We Roche Beckman systems for 27 analytes 681 healthy individuals. were converted into using linear regression (least squares method) which divided two...
<title>Abstract</title> Background Thyroid cancer (TC) is one of the most prevalent endocrine cancers. Moreover, patients with Hashimoto's thyroiditis (HT) are more prone to malignant tumors. The incidence papillary thyroid carcinoma (PTC) combined HT on rise. However, a definitive consensus remains elusive. Methods We retrospectively analyzed clinical and pathological data 2049 PTC (1033 1016 without HT). explored its influence extrathyroidal extension (ETE), central lymph node metastasis...
To establish the reference values and growth curves of skeletal muscle mass among children in Nanjing area.
Abstract Objectives Peripheral blood lymphocyte subsets are important parameters for monitoring immune status; however, subset detection is time-consuming and error-prone. This study aimed to explore a highly efficient clinically useful autoverification system assays performed on the flow cytometry platform. Methods A total of 94,402 test results were collected. To establish limited-range rules, 80,427 first used (69,135 T tests 11,292 NK, B, tests), which 15,000 from human immunodeficiency...