A5100701031- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Sex work and related issues
- Sodium Intake and Health
- Syphilis Diagnosis and Treatment
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Traditional Chinese Medicine Studies
- Reproductive tract infections research
- Hemodynamic Monitoring and Therapy
- Inflammatory mediators and NSAID effects
- Blood transfusion and management
- Reconstructive Surgery and Microvascular Techniques
- Autophagy in Disease and Therapy
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Dermatologic Treatments and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Diet and metabolism studies
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
Harbin Institute of Technology
2023-2025
Anhui Medical University
2023-2025
University of Manchester
2024
Command Hospital
2024
Peking University
2011-2024
Peking University People's Hospital
2011-2024
Hunan University of Finance and Economics
2024
Westlake University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Harbin Medical University
2024
Abstract Purpose: Both CD44 and CD133 were reported as putative markers for isolating colorectal cancer stem cells (CSC). It remains to be resolved if both of these are functional importance CSC. Experimental Design: The expression in normal colonic tissues primary was assessed by immunohistochemistry a series 60 patients on tissue microarray sections. vitro clonogenic vivo tumorigenic assay applied measure CSC activities from the isolated patients. Lentiviral RNA interference used stably...
This study aims to elucidate the impact of varying tourniquet application timings on postoperative pain and bone cement interface following TKA. Patients who underwent TKA in our department between March 2021 July 2023 were included this study. They randomly assigned three groups: Group 1 used tourniquets throughout operation, 2 applied before osteotomy, 3 after completing osteotomy. The general epidemiological data, pressure duration, VAS scores, osteotomy surface preparation, blood loss,...
<h3>Importance</h3> Evidence on HIV preexposure prophylaxis (PrEP) among Chinese men who have sex with (MSM) is critical to guide its large-scale implementation in low- and middle-income countries. <h3>Objective</h3> To evaluate incident infection, adherence, safety, changes sexual behaviors MSM using daily PrEP (D-PrEP) event-driven (ED-PrEP) 4 cities China. <h3>Design, Setting, Participants</h3> This nonrandomized controlled trial was conducted HIV-seronegative from December 11, 2018,...
We detail the training of LLM360 K2-65B model, scaling up our 360-degree OPEN SOURCE approach to largest and most powerful models under project LLM360. While open-source LLMs continue advance, answer "How are trained?" remains unclear within community. The implementation details for such high-capacity often protected due business considerations associated with their high cost. This lack transparency prevents LLM researchers from leveraging valuable insights prior experience, e.g., "What best...
Solvents play a crucial role in ion–molecule reactions and have been used to control the outcome effectively. However, little is known about how solvent molecules affect atomic-level mechanisms. Therefore, we executed direct dynamics simulations of HO−(H2Ow) + CH3CH2Br system elucidate behavior chemical microsolvated environment compared them with previous gas-phase data. Our results show that presence single water molecule significantly suppresses mechanism, reducing its ratio from 0.62...
Abstract The use of poppers is highly prevalent in MSM, but little known about the association between their and HIV incidence China. A prospective cohort study was conducted from 2011 to 2013 MSM Shenyang. 475(79.6%) eligible HIV-negative participated this survey near one fourth (23.4%) ever used poppers. About one-third participants had condomless anal intercourse, half multiple sexual partners 10.5% were syphilis positive. densities were15.5 (95% CI:9.4–23.4)/100 PY[person-years]) 4.6...
// Shiheng Zhang 1, * , Le He Nan Dai 1 Wei Guan Jinlu Shan Xueqin Yang Zhaoyang Zhong Yi Qing Feng Jin Chuan Chen Yuxin Hongyi Wang 4 Laura Baugh Gianluca Tell 2 David M. Wilson III 3 Mengxia Li Dong Cancer Center of Research Institute Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China Laboratory Molecular Biology and DNA repair, Department Biological Sciences, University Udine, Udine 33100, Italy Gerontology, National on Aging, Intramural Program,...
Background: Men who have sex with men (MSM) frequently seek partners through mobile apps (geosocial networking [GSN] apps). However, it is unclear whether GSN apps' use associated the increase in HIV incidence among MSM. Objective: The aim of this study was to clarify characteristics users and determine association putative mechanisms between behavior incidence. Methods: We conducted an 18-month prospective cohort MSM Shenyang, China, participants were surveyed every 3 months from March 2015...
The aim of this study was to provide a basis for the theory that combination conventional chemotherapy and immunotherapy would be an effective treatment osteosarcoma. Here, expression programmed death ligand 1 (PD-L1) in 26 clinical osteosarcoma tissue samples collected before after analyzed. effects cells treated with doxorubicin, chemotherapeutic agent, on proliferation apoptosis CD8 T lymphocytes were investigated vitro. Thereafter, effectiveness doxorubicin combined anti-PD-L1 antibody...
In this study, we identified microRNAs that regulate the expression of programmed death-ligand 1(PD-L1) in osteosarcoma and investigated their role PD-L1-targeted immunotherapy. MicroRNA sequencing analysis showed PD-L1 is regulated by microRNA-200a U2OS, 143B, K7 cells. MicroRNA-200a overexpression induced upregulation CD8+ T cells co-cultured with microRNA-200a-overexpressing reduced survival, proliferation, secretion granzyme B perforin. The same phenomenon was also observed K7-derived...
Abstract Introduction This study explores the preference for daily versus on‐demand pre‐exposure prophylaxis (PrEP) among men who have sex with (MSM) in developing countries when both regimens are available. Methods From 11 December 2018 to 19 October 2019, we recruited MSM an open‐label real‐world PrEP demonstration four major cities China. Subjects selected their preferred (oral tenofovir/emtricitabine) regimen (daily vs. on‐demand) at recruitment and underwent on‐site screening before...
Abstract In this study, we identified the multifaceted effects of atezolizumab, a specific monoclonal antibody against PD-L1, in tumor suppression except for restoring antitumor immunity, and investigated promising ways to improve its efficacy. Atezolizumab could inhibit proliferation induce immune-independent apoptosis osteosarcoma cells. With further exploration, found that atezolizumab impair mitochondria cells, resulting increased release reactive oxygen species cytochrome-c, eventually...
Abstract The development of general catalytic methods for the regio- and stereoselective construction phosphoryl derivatives from identical substrates remains a formidable challenge in organic synthesis. Enabled by newly developed BDPP-type ligands, we disclosed nickel-catalyzed allenylation phosphine oxides rationally predictably, allowing versatile chiral allenylphosphoryl with high enantiopurity (up to 94% e.e.). Alternatively, using an achiral ligand dcypbz under acidic conditions,...
Pre-exposure prophylaxis (PrEP) is a promising and effective tool to prevent human immunodeficiency virus (HIV) transmission; however, context-specific data guide optimal implementation are currently lacking in China. This study aims systematically collect comprehensive, empirical determine ways implement PrEP among at-risk men who have sex with (MSM) The CROPrEP project, real-world of use, will recruit 1000 high-risk HIV-negative MSM participants from four cities China, be able choose...
Introduction Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone preventive cardiology. We developed machine learning (ML) algorithms and investigated their performance in predicting patients’ current CVD (coronary heart disease stroke this study). Materials methods compared traditional logistic regression (LR) with five ML LR Elastic-Net, Random Forest (RF), XGBoost (XGB), Support Vector Machine, Deep Learning, an Ensemble model averaging predictions from RF, XGB,...
Ubiquitous competition of stereospecific E2 elimination versus SN2 substitution is central importance in chemical synthesis. Herein, we uncover how the nature leaving group affects intrinsic competing dynamics that remains largely unknown as opposed to its role reactivity. Results are presented for a prototype case fluoride anion reacting with ethyl chloride, compared iodide. Chemical simulations reproduce scattering signatures observed experiments and reveal direct stripping/rebound...
Abstract Microalbuminuria and hyperuricemia management are crucial for the integrated of hypertensive patients. This retrospective post hoc analysis aims to evaluate optimal allisartan‐isoproxil‐based combination regimen patients with microalbuminuria or hyperuricemia. A total 460 486 were included in this study. All initially treated allisartan‐isoproxil 4 weeks. Thereafter, blood pressure (BP) < 140/90 mmHg continued monotherapy 8 weeks; BP ≥140/90 randomly assigned a 1:1 ratio receive...
HIV self-testing (HIVST) kits are common in key sexually active populations. Direct secondary distribution of HIVST (DSDHK) is effective improving the uptake HIVST. However, there concerns about various limitations DSDHK, including limited geographic reach, payment problems, and need for face-to-face interactions.In this study, we aim to evaluate feasibility characteristics indirect (ISDHK) via WeChat (distributing application links follow-up partners) among men who have sex with (MSM).From...
Ecotourism is a promising solution for channeling tourism revenues to promote nature conservation and poverty alleviation. However, vulnerable social-ecological conditions may limit the effects of ecotourism in dry rangelands around world. This study implemented paired experimental design survey impacts Ergun grassland, one China's most commended regions. Compared with livestock feeding business, local achieved several sustainable development goals, such as providing income people, improving...
Abstract. Here we investigated the effects of P compounds (KH2PO4 and Ca(H2PO4)2) with different addition rates 0, 20, 40, 60, 80, 100 kg ha−1 yr−1 NH4NO3 (0 N yr−1) on soil labile inorganic phosphorus (IP) (dicalcium phosphate, Ca2-P), moderate-cycling IP, recalcitrant IP fractions in a calcareous grassland northeastern China. Soil fractions, not readily available to plants but transforming into soil-available quickly, include variscite (Al-P), strengite (Fe-P) octacalcium phosphate...
The pathophysiology of atopic dermatitis (AD) is complex. CD4
The oxidative-stress-related protein Kelch-like ECH-associated 1 (KEAP1) is a substrate articulator of E3 ubiquitin ligase, which plays an important role in the ubiquitination modification proteins. However, function KEAP1 breast cancer and its impact on survival patients with remain unclear. Our study demonstrates that KEAP1, positive prognostic factor, crucial regulating cell proliferation, apoptosis, cycle transition cancer. We investigate underlying mechanism using human tumor tissues,...