A5102738734- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Liver Disease and Transplantation
- Cytokine Signaling Pathways and Interactions
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Autoimmune Bullous Skin Diseases
- Birth, Development, and Health
- Drug-Induced Hepatotoxicity and Protection
- Advanced Glycation End Products research
- Genetic and Kidney Cyst Diseases
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Psoriasis: Treatment and Pathogenesis
- Toxin Mechanisms and Immunotoxins
- Gestational Diabetes Research and Management
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Mesenchymal stem cell research
- Spondyloarthritis Studies and Treatments
Affiliated Hospital of Southwest Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Optum (United States)
2023
UnitedHealth Group (United States)
2023
Sichuan University
2008-2022
West China Hospital of Sichuan University
2008-2022
Zhejiang University
2019
Fudan University
2014
Shanghai Tenth People's Hospital
2014
Tongji University
2014
Objective: To investigate the predictive value and clinical significance of alpha-fetoprotein (AFP) levels in prognosis patients with liver failure treated artificial plasma exchange (PE). Methods: A retrospective analysis was conducted on data 96 patients. All underwent therapy addition to internal medicine treatments. Based AFP test results, were divided into a low-AFP group (AFP < 100 ng/mL, n = 32), medium-AFP (100 ≤ 200 high-AFP ≥ 32). Serum measured before (2nd day admission), 1st,...
Herpes simplex virus type 1 (HSV-1) is a very concerning pathogen due to its ability persist in the host’s nervous system and continuously interfere with immune system, which complicates treatment. Therefore, development of an effective HSV-1 vaccine crucial. In this study, we focused on mutant strain, M6, includes several deleted genes associated viral infection virulence latent function, explored macrophages immunological characteristics. The study found that both attenuated strain M6...
Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated with liver diseases. But because of population heterogeneity, different races would causative polymorphisms. Therefore, in this study, we included Chinese Tibetans Uygurs to examine the roles these genes on HBV natural clearance. A total 1341 subjects including 908 433 were recruited. Seven single nucleotide polymorphisms (SNP) genotyped. HLA-DP/DQ clearance both ethnicities (Tibetans, rs3077,...
Objective As a candidate gene association study, we investigated the genetic of SNPs in IL-28B genes with different outcomes HBV infection, including LC and HCC occurrence. Methods Chinese Han subjects were categorized into two groups: 406 caused by CHB CHB. Genomic DNA was isolated from whole blood samples, detected using high resolution melting curve (HRM) method. PCR amplification carried out under same conditions 96-well plate Real-Time System. Then 341 356 patients infection analyzed as...
Abstract Although the SLE risk gene loci of HLA-DR and HLA-DQ within major histocompatibility complex (MHC) region has been gradually revealed by recent Genome-Wide Association studies (GWAS), association HLA-DP polymorphisms with was minimally reported. Considering that variants in rs3077 rs9277535 could influence immune response affecting antigen presentation HLA class II molecules to CD4 + T cells, present study aimed explore role SLE. In total, samples from 335 patients 635 healthy...
By utilizing Optum Life Sciences Claims Data, we constructed Real World Data (RWD) cohorts comprising over 3 million patients and simulated a clinical trial observational study design to evaluate 200 FDA-approved drugs with COVID-19 repurposing potential, identified dozen candidates exhibiting significant reduction in the odds of severe outcomes such as death, intensive care unit (ICU) admission, hospitalization pneumonia. Notably, certain drug combinations demonstrated effects comparable...
Background Currently, the pathogenesis of rheumatoid arthritis (RA) is not clearly understood. The LIGHT/HVEM/BTLA co-signaling pathway may be involved in RA, although reports on expression levels LIGHT, HVEM and BTLA T lymphocytes from RA patients are limited. Method In this study, we recruited 30 healthy controls 21 patients. Clinical characteristics were collected for expressed surface circulating cells measured by flow cytometry. Result percentages CD3+, CD4+ CD8+ that all higher than...
Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, liver function. Our results showed that circulating interleukin (IL)-17 may be helpful spontaneous clearance [odds ratio <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mfenced open="(" close=")"> <a:mrow> <a:mtext>OR</a:mtext> </a:mrow> </a:mfenced>...
IgA nephropathy (IgAN) is the most common chronic glomerular disease worldwide. Genetic factors are thought to be crucial in pathogenesis of IgAN. However, few data available on relationship between human leucocyte antigen (HLA) and signal transducer activator transcription 4 (STAT4) polymorphisms IgAN susceptibility Chinese population. Therefore, we examined HLA-DP/DQ STAT4 (rs3077, rs9277535, rs7453920 rs7574865) a total 630 subjects including 140 490 healthy controls Chinese. There were...
The association between a single-nucleotide polymorphism (SNP; -607A/C) in the promoter region of IL-18 gene with transcription activity and level protein production has been observed repeatedly. However, IL-18-607A/C (rs1946518) IgA nephropathy (IgAN) Chinese Han population is still unclear. A total 166 patients renal biopsy-proven IgAN 198 healthy controls were recruited for this study. SNP was genotyped by polymerase chain reaction high-resolution melting method. Clinical characteristics...