A5107335628- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Geological and Geochemical Analysis
- Animal Disease Management and Epidemiology
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 detection and testing
- Peripheral Neuropathies and Disorders
- High-pressure geophysics and materials
- vaccines and immunoinformatics approaches
- Geochemistry and Geologic Mapping
- Vaccine Coverage and Hesitancy
- High-Energy Particle Collisions Research
- Inflammatory Biomarkers in Disease Prognosis
- Paleontology and Stratigraphy of Fossils
- Intramuscular injections and effects
- Retinal and Optic Conditions
- Atherosclerosis and Cardiovascular Diseases
- Whipple's Disease and Interleukins
- Infection Control and Ventilation
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Air Force Medical University
2024
Xijing Hospital
2024
Chinese Academy of Geological Sciences
2020-2023
Ministry of Natural Resources
2022
Institute of Medical Biology
2021
University of Shanghai for Science and Technology
2021
Jiangxi Agricultural University
2021
Czech Academy of Sciences, Institute of Geology
2020
Shandong Tumor Hospital
2020
Abstract Background We evaluated an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for immunogenicity and safety in adults aged 18–59 years. Methods In this randomized, double-blinded, controlled trial, healthy received a medium dose (MD) or high (HD) of the at interval either 14 days 28 days. Neutralizing antibody (NAb) anti-S anti-N antibodies were detected different times, adverse reactions monitored after full immunization. Results A total 742 enrolled...
Herpes simplex virus type 1 (HSV-1) is a very concerning pathogen due to its ability persist in the host’s nervous system and continuously interfere with immune system, which complicates treatment. Therefore, development of an effective HSV-1 vaccine crucial. In this study, we focused on mutant strain, M6, includes several deleted genes associated viral infection virulence latent function, explored macrophages immunological characteristics. The study found that both attenuated strain M6...
Neutralizing antibodies in the subjects of an inactivated SARS-CoV-2 vaccine clinical trial showed a decreasing trend over months. An investigation studying third immunization suggested that waning neutralizing individuals administered two doses does not mean disappearance immunity.
Intracontinental transform structures are important forms of continental deformation, such as the Altyn Tagh fault on Tibetan Plateau. Although many intracontinental have developed throughout geological history, their identification is relatively difficult due to later deformation and sedimentary covering. Strike-slip faults played an role in formation subsequent transformation Central Asian orogenic belt (CAOB). In this study, a group nearly EW-trending dextral shear zones along southern...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike (S) protein is a critical viral antigenic that enables the production of neutralizing antibodies, while other structural proteins, including membrane (M), nucleocapsid (N) and envelope (E) have unclear roles in antiviral immunity. In this study, S1, S2, M, N E proteins were expressed 16HBE cells to explore characteristics resultant innate immune response. Furthermore, peripheral blood mononuclear (PBMCs) from mice...
Abstract BACKGROUND In-depth investigations of the safety and immunogenicity inactivated SARS-CoV-2 vaccines are needed. METHOD In a phase I randomized, double-blinded, placebo-controlled trial involving 192 healthy adults 18-59 years age, two injections three different doses (50 EU, 100 EU 150 EU) an vaccine or placebo were administered intramuscularly with 2- 4-week interval between injections. The evaluated within 28 days. FINDING this study, 191 subjects assigned to groups group...
Abstract With the relatively serious global epidemic outbreak of SARS-CoV-2 infection, public concerns focus on not only clinical therapeutic measures and quarantine for this disease but also development vaccines. The technical design our inactivated vaccine provides a viral antigen that enables exposure more than one structural protein based upon antibody composition COVID-19 patients’ convalescent serum. This led to valid immunity with increasing neutralizing titers CTL response detected...
Because of the relatively limited understanding coronavirus disease 2019 (COVID-19) pathogenesis, immunological analysis for vaccine development is needed. Mice and macaques were immunized with an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) prepared by two inactivators. Various indexes tested, viral challenges performed on day 7 or 150 after booster immunization in monkeys. This SARS-CoV-2 was produced sequential inactivation formaldehyde followed propiolactone. The various...
(1) Background: As the COVID-19 pandemic enters its fourth year, it continues to cause significant morbidity and mortality worldwide. Although various vaccines have been approved use of homologous or heterologous boost doses is widely promoted, impact vaccine antigen basis, forms, dosages, administration routes on duration spectrum vaccine-induced immunity against variants remains incompletely understood. (2) Methods: In this study, we investigated effects combining a full-length spike mRNA...
Recent studies have indicated that sequentially administering SARS-CoV-2 vaccines can result in increased antibody and cellular immune responses. In this study, we compared homologous heterologous immunization strategies following two doses of inactivated a mouse model. Our research demonstrates sequential resulted more responses displayed the lymph node germinal center, which induced greater number antibody-secreting cells (ASCs), resulting enhanced humoral cross-protection against five...
Objective: We constructed two DNA vaccines containing the receptor-binding domain (RBD) genes of multiple SARS-CoV-2 variants and used them in combination with inactivated a variety different protocols to explore potential novel immunization strategies against variants. Methods: Two vaccine candidates signal peptides (namely, secreted membrane peptides) RBD protein strains (Wuhan-Hu-1, B.1.351, B.1.617.2, C.37) were used. Four combinations tested, namely, Group A: three doses vaccine; B: one...
Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics type 16 (CA16) are thought to correlate pathological process its infection. Two CA16 strains that were isolated from a severe HFMD patient presented different plaque forms. This observation, along biological analysis, indicated differences in strains' characteristics, such as proliferation kinetics immunogenicity, their pathogenicity toward neonatal mice....
The Alxa Block is an important component of the North China Craton, but its metamorphic basement has been poorly studied, which hampers understanding and Craton. In this study, we conducted geochronological geochemical studies on three TTG (tonalite–trondhjemite–granodiorite) gneisses one granitic gneiss exposed in Langshan area eastern to investigate their crustal evolution. zircon U-Pb dating results revealed that protoliths were formed at 2836 ± 20 Ma, 2491 18 2540 38 2763 42...
Hand, foot and mouth disease is a common acute viral infectious that poses serious threat to the life health of young children. With development an effective inactivated EV71 vaccine, CA16 has become main pathogen causing HFMD. Effective safe vaccines against this are urgently needed. In our previous study, bivalent vaccine was shown have good immunogenicity induce neutralizing antibodies in mice monkeys. Repeated administration toxicity critical safety test preclinical evaluation vaccines....
The recent emergence of COVID-19 variants has necessitated the development new vaccines that stimulate formation high levels neutralizing antibodies against S antigen variants. A strategy involves intradermal administration heterologous composed one or two doses inactivated vaccine and a booster dose with mutated S1 protein (K-S). Such improve immune efficacy by increasing antibody titers promoting specific T cell responses five RBD protein. viral challenge test B.1.617.2 (Delta) variant...
Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via binding its various envelope glycoproteins to cellular membrane receptors, one which is herpes entry mediator (HVEM), expressed on dendritic cells. Here, HVEM gene-deficient mice were used investigate immunologic effect elicited by HSV-1 infection Dendritic expressing surface marker CD11c showed abnormal biological phenotype, including altered transcription immune signaling molecules...