A5100366452- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- COVID-19 Clinical Research Studies
- Radiation Effects and Dosimetry
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Chronic Kidney Disease and Diabetes
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Long-Term Effects of COVID-19
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- Structural Health Monitoring Techniques
- Ginseng Biological Effects and Applications
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Tianjin Medical University
2007-2024
Northern Jiangsu People's Hospital
2022-2024
First Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2024
Kunming University of Science and Technology
2024
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
National Institute for Viral Disease Control and Prevention
2021-2023
Yangzhou University
2023
The Woronin body is a peroxisome-derived dense-core vesicle that specific to several genera of filamentous ascomycetes, where it has been shown seal septal pores in response cellular damage. Hexagonal peroxisome (Hex1) protein was recently identified as major constituent the and be responsible for self-assembly dense core this organelle. Using mutation Magnaporthe grisea HEX1 ortholog, we define dual essential function bodies during pathogenic phase rice blast fungus. We show initially...
Background: Bone marrow mesenchymal stem cell (BMSC) therapy is a novel approach for treating COPD. However, the difficulty in engraftment and easy clearance of BMSCs vivo has hindered their clinical application. Hence, exploring effective methods to improve differentiation rates urgent. Methods: We constructed overexpressing Wnt3a by lentivirus infection transplanted them into COPD rat model. The damage level lung tissue was assessed pathology analysis inflammatory cytokines analysis. BMSC...
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations. Age, mechanical stress inflammation are factors that induce degeneration in pathogenesis of OA. Sinensetin (SIN) natural flavonoid with anti-inflammatory antioxidant properties. This study aims to investigate effect SIN on We have investigated chondroprotective effects...
This single-center, retrospective study aimed to explore the immune characteristics of COVID-19 and biomarkers predict severity this disease. Patients infected with SARS-CoV-2 (n = 215) treated at First Affiliated Hospital Nanchang University from January 24 March 12, 2020, were included in classified into severe non-severe groups. Peripheral immunocyte count cytokine statuses compared. The correlation between status, levels, disease was analyzed. Leukocyte numbers normal both groups;...
Abstract Nutrient-limiting conditions are common during cancer development. The coordination of cellular glucose levels and cell survival is a fundamental question in biology has not been completely understood. 4EBP1 known as translational repressor to regulate proliferation by controlling translation initiation, however, whether could participate tumor other mechanism except for repression function, especially under starvation remains unknown. Here, we found that protein was up-regulated...
Weaning is the most critical phase in pig production and generally associated with significant impacts on intestinal morphology, structure, physiology, immune responses, which can lead to subsequent inefficiencies such as decreases growth intake increases morbidity mortality. In present study, we attempted explore effects of fecal microbiota transplantation (FMT) microbiota, metabolites, transcriptome jejunum, colon, liver, spleen, oral mucosa piglets post-weaning diarrhea evaluate...
Abstract The nucleocapsid protein (N protein) has been found to be an antigenic in a number of coronaviruses. Whether the N severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is remains elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA), recombinant proteins synthesized peptides derived from were screened sera SARS patients. All patient this study displayed strong positive immunoreactivities against proteins, whereas normal gave negative...
Many types of dosimeters are used to measure radiation dose and calibrate radiotherapy equipment, but none directly the biological effect this dose. The purpose here is create a dosimeter that can probability double-strand breaks (DSB) for DNA, which related radiation.A DNA dosimeter, consisting magnetic streptavidin beads attached four kilobase pair strands labeled with biotin fluorescein amidite (FAM) on opposing ends, was suspended in phosphate-buffered saline (PBS). Fifty microliter...
Yeast Rad1-Rad10 (XPF-ERCC1 in mammals) incises UV, oxidation, and cross-linking agent-induced DNA lesions, contributes to multiple repair pathways. To determine how catalyzes inter-strand crosslink (ICLR), we examined sensitivity ICLs from yeast deleted for SAW1 SLX4, which encode proteins that interact physically with bind stalled replication forks. Saw1, Slx1, Slx4 are critical replication-coupled ICLR mus81 deficient cells. Two rad1 mutations disrupt interactions between Rpa1 selectively...
Diabetes is a chronic disease and has huge pressure on patients the medical system, especially for with diabetic complications, example, nephropathy. Diabetic nephropathy complication associated damage to kidney. To improve quality of life diabetes, it necessary understand factors that are The objective study was find prevalence in newly diagnosed diabetes develop association between clinicopathological parameters In case-control study, demographics, anthropometric, total 305 (the fasting...
Abstract Osteoarthritis (OA) is a degenerative disease characterized by cartilage wear and degradation. Ginkgolide K (GK) natural compound extracted from Ginkgo biloba leaves possesses anti‐inflammatory anti‐apoptotic effects. We found that the biological characteristics of GK were highly consistent with those OA medications. This study aimed to determine verify therapeutic effect on mechanism its effect. For in vivo experiment, rats regularly injected articular cavity GK, curative effects...
The coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern (VOCs) are circulating worldwide, making it resistant to existing vaccines and antiviral drugs. Therefore, the evaluation variant-based expanded spectrum optimize immune response provide broad protectiveness very important. In this study, we expressed spike trimer protein (S-TM) based on Beta variant in a GMP-grade workshop using CHO cells. Mice were...
Abstract Background: VT (Ventricular Thrombus) is a serious complication of dilated cardiomyopathy (DCM). Our goal to develop nomogram for personalized prediction incident in DCM patients. Methods: 1267 patients (52.87 ± 11.75 years old, 73.8% male) were analyzed retrospectively from January 01, 2015, December 31, 2020. A model risk assessment was established using minimum absolute contraction and selection operator (LASSO) multivariate logistic regression analysis, its effectiveness...
In this work, we developed a DNA dosimeter, consisting of 4-kb strands attached to magnetic streptavidin beads and labeled with fluorescein, detect double-strand breaks (DSBs). The purpose here was evaluate whether the dosimeter readings reflect relative biological effects 160 kVp 6 MV X rays. AVarian 600 C/D linac (6 MV) Faxitron cabinet X-ray system (160 kVp), both calibrated using traceable methods, were used deliver high- low-energy photons, respectively, dosimeters multiple cell lines...
The recent emergence of COVID-19 variants has necessitated the development new vaccines that stimulate formation high levels neutralizing antibodies against S antigen variants. A strategy involves intradermal administration heterologous composed one or two doses inactivated vaccine and a booster dose with mutated S1 protein (K-S). Such improve immune efficacy by increasing antibody titers promoting specific T cell responses five RBD protein. viral challenge test B.1.617.2 (Delta) variant...
The tripeptide tyroservatide (tyrosyl-seryl-valine, pTyr-Ser-Val-NH2) has been shown to have antitumor effects on experimental hepatocarcinoma. This study aimed observe the of other five human carcinomas: A549 (nonsmall cell lung carcinoma), BGC-823 (gastric cancer), MCF-7 (breast K562 (leukemia), A375 (melanoma) and two murine cancers: Lewis cancer B16 in vivo. In vivo nude mice bearing xenografts different tumors or C57BL/6 were given daily intraperitoneal injections saline as controls,...
Introduction: Osteoarthritis (OA) is a prevalent clinical chronic degenerative condition characterized by the degeneration of articular cartilage. Currently, drug treatments for OA come with varying degrees side effects, making development new therapeutic approaches imperative. Mesenchymal stem cells (MSCs) are known to mitigate progression primarily through paracrine effects. The conditioned medium (CM) derived from MSCs encapsulates variety factors secreted these cells. Methods: In this...