A5103200095- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Effects and Dosimetry
- DNA Repair Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Radiation Dose and Imaging
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Berberine and alkaloids research
- Colorectal Cancer Treatments and Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Semantic Web and Ontologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- IgG4-Related and Inflammatory Diseases
- Biomedical Text Mining and Ontologies
- SARS-CoV-2 detection and testing
- Cardiac tumors and thrombi
- Platelet Disorders and Treatments
- COVID-19 diagnosis using AI
- Hearing, Cochlea, Tinnitus, Genetics
Semmelweis University
2025
University of Jordan
2024
Al-Balqa Applied University
2024
Stanford University
2023
Tafila Technical University
2023
University of Iowa Hospitals and Clinics
2020-2022
University of Iowa
2020-2021
The University of Texas Health Science Center at San Antonio
2015-2020
The University of Texas at San Antonio
2016
University of North Carolina at Chapel Hill
2015
Purpose This study aims to standardize the simulation procedure in measuring DNA double‐strand breaks ( DSB s), by using advanced Monte Carlo toolkits, and newly introduced experimental methods for measurement. Methods For quantification of , an innovative dosimeter was used produce data. GATE combination with Geant4‐ toolkit were exploited simulate environment. The PDB 4 example upgraded investigated. Parameters such energy threshold ET ) a strand break base pair BPT evaluated, depending on...
Abstract A patient specific quality assurance ( QA ) should detect errors that originate anywhere in the treatment planning process. However, increasing complexity of plans has increased need for improvements accuracy pretreatment verification This led to utilization higher resolution methods such as electronic portal imaging device EPID well MLC log files and it is important know types can be detected with these methods. In this study, we will compare ability three (Delta 4 ®, MU ‐ ,...
Many types of dosimeters are used to measure radiation dose and calibrate radiotherapy equipment, but none directly the biological effect this dose. The purpose here is create a dosimeter that can probability double-strand breaks (DSB) for DNA, which related radiation.A DNA dosimeter, consisting magnetic streptavidin beads attached four kilobase pair strands labeled with biotin fluorescein amidite (FAM) on opposing ends, was suspended in phosphate-buffered saline (PBS). Fifty microliter...
COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with increasing number cases and significant mortality worldwide. Clinical trials extensive studies are being conducted on a large scale for better understanding pathophysiology this disease its effect different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one first drugs used. While patients can develop many side effects HCQ, documented rare association long-term...
Purpose: Many types of dosimeters are used to measure radiation, but none them directly measures the biological effect this dose. The purpose here is create a dosimeter that can probability double‐strand breaks (DSB) for DNA, which related radiation. Methods: has DNA strands, labeled on one end with biotin and other fluorescein. attaches these strands magnetic beads. We suspended in phosphate‐buffered saline (PBS) as it matches internal environment body. placed small volumes (50µL) into...
Introduction The Newborn Hearing Screening (NHS) program was officially launched in Jordan 2021. Since its inception, no studies have examined the effectiveness of program. This study seeks to assess and outcomes NHS Jordan. Methods A retrospective cross-sectional conducted investigate coverage rate, referral loss follow-up rate hearing status newborns who successfully completed necessary diagnostic assessment. Live births all hospitals administered by Ministry Health (MoH) from July 2021...
Abstract Introduction/Objective Human epidermal growth factor receptor 2 (HER2/neu) is a well-established therapeutic target in breast and gastric cancers. Currently HER2 expression being considered other solid tumors including colorectal cancer (CRC). We aimed to investigate CRC among Jordanians its association with clinicopathological variables. Methods/Case Report Formalin-fixed, paraffin-embedded tissue blocks of 69 cases were retrieved their data. Tissue microarray (TMA) constructed...
We developed a dosimeter that measures biological damage following delivery of therapeutic beams in the form double-strand breaks (DSBs) to DNA. The contains DNA strands are labeled on one end with biotin and other fluorescein attached magnetic microbeads. Following irradiation, magnet is used separate broken from unbroken strands. Then, fluorescence utilized measure relative amount determine probability for DSB. long-term goal this research evaluate whether type biologically based holds any...
Background: Colorectal cancer (CRC) is a common malignancy in Jordan, it was the third most male and female, curable if detected early stage. Objectives: The objective to study epidemiological, clinical, pathological features of CRC patients analyzed prognosis this disease among our Jordanian King Hussein medical city at Amman - Jordan. Materials Methods: Retrospective cross-sectional done KHMC. Totally, 500 with proven diagnosed included study. A detailed clinical history taken. And...
The potential of Multi-Agent Systems (MAS) in tackling the complexities biomedical literature searches has been increasingly recognized.This research delves into application MAS for amalgamation varied information sources and expertise, striving a higher degree accuracy comprehensiveness search results.A distinct framework, designed implemented specifically searching, is introduced.In this decentralized agents are employed, each bearing responsibility specific tasks such as data collection,...
Purpose: A DNA double-strand break (DSB) dosimeter was developed to measure the biological effect of radiation. The goal here is refine fabrication method this reproducibly create a low coefficient variation (CoV) and reduce cost for dosimeter. Methods: Our consists 4 kilo-base pair strands (labeled on one end with biotin other fluorescein) attached streptavidin magnetic beads. final step suspend these beads in phosphate-buffered saline (PBS). amount PBS used relative volume both affect CoV...
Early in the Severe Acute Respiratory Syndrome Coronavirus 2 pandemic, there was a progressive increase diagnostic demands that developed within relatively short period of time. On February 4, 2020, Secretary Health and Human Services issued Emergency Use Authorization for vitro diagnostics assays virus. Subsequently, multiple were approved under Authorization, including Cepheid Xpert SARS-CoV-2 assay. Presented here is description nationally coordinated verification study assay performed...
Purpose: Radiotherapy treatment is specified by radiation dose prescriptions, but biological DNA damage actually controls effectiveness. It impractical to directly measure in the clinic, so we quantities, such as collected charge, and calculate relationship dose. At small fields, those stereotactic radiosurgery (SRS), charged‐particle equilibrium (CPE) breaks down accuracy of measurement for delivered decreases. By measuring double‐strand (DSB) directly, believe could improve providing a...
Purpose: In this study we will compare the ability of three QA methods (Delta4, MU‐EPID, Dynalog QA) to detect specific errors. Methods: A Varian Novalis Tx with a HD120 MLC and aS1000 Electronic Portal Imaging Device (EPID) was used in our study. Multi‐leaf collimator (MLC) errors, gantry angle dose errors were introduced into 5 volumetric arc therapy (VMAT) plans. 3D distributions calculated data from EPID compared planned distribution. The gamma passing percentages as well percentage...
A 12-year-old female presented with weight gain, edema, and shortness of breath. Laboratory urine studies confirmed nephrotic syndrome presence a mediastinal mass, identified as mature teratoma after resection. Nephrotic persisted despite resection renal biopsy minimal change disease, which ultimately responded to steroid treatment. She had two relapses vaccination administration, both occurred within eight months tumor were responsive steroids. Autoimmune infectious workup for other causes...
Radiation therapy (RT) is a standard treatment for organ confined prostate cancer (PCa). Although dose escalation increases local control, further hampers effectiveness due to toxicity. Additionally, intrinsic and acquired resistance radiation causes progression advanced metastatic PCa. Therefore, there an urgency addition of adjuvant therapies that synergize with improve therapeutic efficacy. We have identified novel combination regimen (Nexrutine, Nx, natural compound plus radiation)...