A5033535340- Mitochondrial Function and Pathology
- Reproductive Biology and Fertility
- Ovarian function and disorders
- ATP Synthase and ATPases Research
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Cardiac Ischemia and Reperfusion
- Neonatal Respiratory Health Research
- Wheat and Barley Genetics and Pathology
- Genetics and Plant Breeding
- Birth, Development, and Health
- Gestational Trophoblastic Disease Studies
- Burn Injury Management and Outcomes
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Contraception
- Soil and Environmental Studies
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Toxoplasma gondii Research Studies
- Calcium signaling and nucleotide metabolism
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Crop Yield and Soil Fertility
- Cardiac electrophysiology and arrhythmias
- Parasitic Infections and Diagnostics
Heim Pál Gyermekkórház
2025
University of Pecs
2014-2024
Hungarian Academy of Sciences
1970-2017
Szent János Kórház
2015-2017
Agricultural Institute
2012
Centre for Agricultural Research
2012
Agrárközgazdasági Intézet
2011
University of Tübingen
2009
Stahl-Zentrum (Germany)
2005
Capital University
1970
According to the classical view, cytoprotective effect of inhibitors poly(ADP-ribose)polymerase (PARP) in oxidative stress was based on prevention NAD+ and ATP depletion, thus attenuation necrosis. Our previous data PARP an inflammatory model suggested that PARP-catalyzed ADP-ribosylations may affect signaling pathways, which can play a significant role cell survival. To clarify molecular mechanism cytoprotection, activity inhibited pharmacologically by suppressing PARP-1 expression small...
The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 activates Akt, and showed this response plays a critical role the maintenance mitochondrial integrity survival. However, it has not yet been defined how nuclear signals cytoplasmic Akt.WRL 68, HeLa MCF7 cells were grown culture. Oxidative stress was induced with hydrogen peroxide. PARP inhibited...
Obesity is a major public health problem worldwide, and it associated with many diseases abnormalities, most importantly, type 2 diabetes. The visceral adipose tissue produces an immense variety of adipokines. Leptin the first identified adipokine which plays crucial role in regulation food intake metabolism. Sodium glucose co-transport inhibitors are potent antihyperglycemic drugs various beneficial systemic effects. We aimed to investigate metabolic state leptin level among patients...
We identified a sequence homologous to the Bcl-2 homology 3 (BH3) domain of proteins in SOUL. Tissues expressed protein different extents. It was predominantly located cytoplasm, although fraction SOUL associated with mitochondria that increased upon oxidative stress. Recombinant facilitated mitochondrial permeability transition and collapse membrane potential (MMP) release proapoptotic intermembrane (PMIP) at low calcium phosphate concentrations cyclosporine A-dependent manner vitro...
We found that heme‐binding protein 2/SOUL sensitised NIH3T3 cells to cell death induced by A23187 and etoposide, but it did not affect reactive oxygen species formation. In the presence of sub‐threshold calcium, recombinant SOUL provoked mitochondrial permeability transition (mPT) in vitro was inhibited cyclosporine A (CsA). This effect verified vivo monitoring dissipation membrane potential. Flow cytometry analysis showed promoted necrotic etoposide treated cells, which prevented CsA. These...
Previous studies on the degenerative animal model of multiple sclerosis suggested that copper-chelator cuprizone might directly suppress T-cell functions. Peripheral function in has already been explored; therefore, present study, we investigated, for first time, how feeding affects thymus, organ maturation and selection. We found even one week treatment induced significant thymic atrophy, affecting cortex over medulla. Fluorescent microscopy flow-cytometric analyses thymi from cuprizone-...
Amiodarone is a widely used and potent antiarrhythmic agent that metabolized to desethylamiodarone. Both amiodarone its metabolite possess effect, both compounds can contribute toxic side effects. Here, we compare the effect of desethylamiodarone on mitochondrial energy metabolism, membrane potential, permeability transition mitochondria-related apoptotic events. but not protects metabolism perfused heart during ischemia in hearts. At low concentrations, stimulated state 4 respiration due an...
Noradrenaline (NA), serotonin (5HT), dopamine (DA), FSH, LH and prolactin (PRL) content was determined in 104 preovulatory follicular fluids obtained from 44 patients undergoing vitro fertilization. The were given human menopausal gonadotropin (HMG) for ovarium stimulation, ovulation induced with 10000 IU chorionic (HCG) 34-36 hours prior to the aspiration by vaginal ultrasound. Classification of oocytes performed direct microscopic evaluation differentiating three groups oocytes: Group I.:...
The high incidence of low-weight births (not exceeding 2,500g.) is a serious public health problem in Hungary where the deaths low birth weight babies accounted for 68-4% infant mortality and 83-0% first week 1967.The proportion probably higher than any other European country appears to be increasing (Table I).The work pre- sented here an attempt investigate reasons this.It based on examination data recorded between 1950 basic are presented Table II.Mean decreased linearly from 1962 has...
Bladder cancer (BC) is a common malignancy of the urinary tract that has higher frequency in men than women. Cytostatic resistance and metastasis formation are significant risk factors BC therapy; therefore, there great interest overcoming drug initiating research for novel chemotherapeutic approaches. Here, we suggest desethylamiodarone (DEA)-a metabolite amiodarone-may have cytostatic potential. DEA activates collapse mitochondrial membrane potential (detected by JC-1 fluorescence),...