A5051705380- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Plant Genetic and Mutation Studies
- Carcinogens and Genotoxicity Assessment
- Radiation Detection and Scintillator Technologies
- Electron and X-Ray Spectroscopy Techniques
- Speech Recognition and Synthesis
- Radiation Effects in Electronics
- Phonetics and Phonology Research
- Particle physics theoretical and experimental studies
- Voice and Speech Disorders
- Muon and positron interactions and applications
- Radiation Dose and Imaging
- Particle Detector Development and Performance
- Telomeres, Telomerase, and Senescence
- Boron Compounds in Chemistry
- Planetary Science and Exploration
- Advanced X-ray and CT Imaging
- Machine Learning in Materials Science
- COVID-19 diagnosis using AI
- Radiation Effects and Dosimetry
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
Inserm
2023-2025
Laboratoire de Traitement de l'Information Médicale
2023-2025
Université de Bretagne Occidentale
2023-2025
General University Hospital of Patras
2025
Laboratoire de Physique des deux infinis Bordeaux
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Université de Bordeaux
2023-2024
National and Kapodistrian University of Athens
2024
University of Patras
2016-2023
The scientific community shows a great interest in the study of DNA damage induction, repair and biological effects on cells cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far these mechanisms using Monte Carlo simulations. This outlines Geant4-DNA example application, named "molecularDNA", publicly released 11.1 version Geant4 (December 2022). It was developed for novice users requires only basic understanding scripting languages get...
Purpose This study aims to standardize the simulation procedure in measuring DNA double‐strand breaks ( DSB s), by using advanced Monte Carlo toolkits, and newly introduced experimental methods for measurement. Methods For quantification of , an innovative dosimeter was used produce data. GATE combination with Geant4‐ toolkit were exploited simulate environment. The PDB 4 example upgraded investigated. Parameters such energy threshold ET ) a strand break base pair BPT evaluated, depending on...
The evolution of 3D printing has ushered in accessibility and cost-effectiveness, spanning various industries including biomedical engineering, education, microfluidics. In it encompasses bioprinting tissues, producing prosthetics, porous metal orthopedic implants, facilitating educational models. Hybrid Additive Manufacturing approaches and, more specifically, the integration Fused Deposition Modeling (FDM) with bio-inkjet offers advantages improved accuracy, structural support, controlled...
Abstract Objective: A methodology is introduced for the development of an internal dosimetry prediction toolkit nuclear medical pediatric applications. The proposed study exploits Artificial Intelligence techniques using Monte Carlo simulations as ground truth accurate absorbed doses per organ prior to imaging acquisition considering only personalized anatomical characteristics any new patient. Approach: GATE were performed a population computational models calculate specific dose rates...
This study investigated alternative, non-invasive methods for human papillomavirus (HPV) detection in head and neck cancers (HNCs). We compared two approaches: analyzing computed tomography (CT) scans with a Deep Learning (DL) model using radiomic features extracted from CT images machine learning (ML) models.
Purpose This study proposes a novel computational platform that we refer to as IDDRRA (DNA Damage Response Ionizing RAdiation), which uses Monte Carlo (MC) simulations score radiation induced DNA damage. MC provide results of high accuracy on the interaction with matter while scoring energy deposition based state‐of‐the‐art physics and chemistry models probabilistic methods. Methods The software is Geant4‐DNA toolkit together new tools were developed for purpose this study, including...
Purpose Based on considerable interest to enlarge the experimental database of radioresistant cells after their irradiation with helium ions, HTB140, MCF-7 and HTB177 human malignant are exposed ion beams having different linear energy transfer (LET).
Optical Monte Carlo simulations have been extensively used for the accurate modeling of light transport in scintillators improvement detector designs. In present work, a GATE toolkit was to study effect scintillator thicknesses and septa materials performance parameters evaluation commercially available small animal gamma-optical camera, named “γ-eye”. Firstly, simulated γ-eye system validated against experimental data. Then, part camera modeled defining all optical properties by means...
Purpose: Pediatric tumors are generally treated with multi‐modal procedures. Brachytherapy can be used pediatric tumors, especially given that in this patient population low toxicity on normal tissues is critical as the suppression of probability for late malignancies. Our goal to validate GATE toolkit realistic brachytherapy applications, and evaluate plans pediatrics accurate dosimetry sensitive organs interest. Methods: The Monte Carlo (MC) was used. Two High Dose Rate (HDR) 192Ir sources...
In recent years, the use of Monte Carlo (MC) simulations in domain Medical Physics has become a state-of-the-art technology that consumes lots computational resources for accurate prediction particle interactions. The generative adversarial network (GAN) been recently proposed as an alternative to improve efficiency and extending applications tools both medical imaging therapeutic applications. This study introduces new approach simulate positron paths originating from Fluorine 18 (18 F)...
Exposure to ionizing radiation can induce genetic aberrations via unrepaired DNA strand breaks. To investigate quantitatively the dose–effect relationship at molecular level, we irradiated dry pBR322 plasmid with 3 MeV protons and assessed fragmentation yields different doses using long-read sequencing from Oxford Nanopore Technologies. This technology applied a reference model revealed dose-dependent fragmentation, as evidenced by read length distributions, showing no discernible...
The advances in the development of Facilitative Playbacks extracted from High-Speed videoendoscopic sequences vocal folds are hindered by a notable lack publicly available datasets annotated with semantic segmentations corresponding to area glottal gap. This fact also limits reproducibility and further exploration existing research this field. To address gap, GIRAFE is data repository designed facilitate advanced techniques for segmentation, analysis, fast evaluation folds. includes 65...
This study aims to validate GATE and GGEMS simulation toolkits for brachytherapy applications provide accurate models six commercial seeds, which will be freely available research purposes. The AAPM TG-43 guidelines were used the validation of two Low Dose Rate (LDR), three High (HDR), one Pulsed (PDR) seeds. Each seed was represented as a 3D model then simulated in produce single Phase-Space (PHSP) per seed. To test validity simulations' outcome, referenced data (provided by TG-43) compared...