A5101552747- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Seaweed-derived Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Glycosylation and Glycoproteins Research
- Medical Imaging and Pathology Studies
- Cell Adhesion Molecules Research
- Synthesis and biological activity
Hangzhou City University
2025
Tianjin Medical University
2014-2024
Harbin Institute of Technology
2024
Shandong Tumor Hospital
2013-2023
Shandong First Medical University
2013-2023
Changjiang Institute of Survey, Planning, Design and Research
2022
Tianjin Institute of Pharmaceutical Research (China)
2017-2022
Peking University
2022
Shandong University
2015-2021
Affiliated Hospital of Southwest Medical University
2021
Significance How NK cell development diverges from T/B commitment at the common lymphoid progenitor stage is poorly understood. Histone modification near critical gene loci often influences lineage determination. Ezh2 a histone methyltransferase frequently associated with repression. Here we observed that Ezh2-null hematopoietic stem and cells (HSPCs) or HSPCs treated inhibitors gave rise to increased precursors mature progeny display enhanced cytotoxicity against tumor cells. The latter...
Background The radiotracer fluorine 18 (18F)–labeled fibroblast activation protein inhibitor (FAPI) has shown promise for visualizing several types of cancer, but the accuracy 18F-FAPI compared with 18F-fluorodeoxyglucose (FDG) detection lung cancer remains uncertain. Purpose To evaluate effectiveness 18F-FAPI–based PET/CT imaging diagnosis primary and metastatic lesions as 18F-FDG PET/CT. Materials Methods In this secondary analysis a prospective trial, consecutively recruited patients from...
// Ran Liu 1, * , Huiting Wei 2, Peng Gao 3 Hu Yu 4 Ke Wang Zheng Fu 2 Baohui Ju 5 Meng Zhao Shangwen Dong 6 Zhijun Li Yifeng He 7 Yuting Huang and Zhi Yao 1 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science Technology, University, Tianjin, 300072, China Department Immunology, Cellular Molecular Educational Ministry China, Basic Medical Sciences, 300071, University the District Columbia, Washington D.C., 20008, United States Cancer...
Heterogeneity is found in the tumor microenvironment among different pathological types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an important tracer for non-invasive imaging microenvironment, can be used to evaluate expression FAP cancer-associated fibroblasts, macrophages, and cells. Our aim was explore ability [18F]AlF-NOTA-FAPI-04 positron emission tomography (PET)/computed (CT) distinguish lung cancer by evaluating uptake this primary metastatic...
The primary aim of this study was to use serial <sup>18</sup>F-3′-deoxy-3′-fluorothymidine (FLT) PET/CT measure tumor cell proliferation during radiotherapy squamous carcinoma (SCC) the esophagus. <b>Methods:</b> Twenty-one patients with inoperable locally advanced SCC esophagus underwent <sup>18</sup>F-FLT radiotherapy. Each patient received a pretreatment scan, followed by 1–3 scans after delivery 2, 6, 10, 20, 30, 40, 50, or 60 Gy tumor. <b>Results:</b> Among 19 who completed without...
To explore the relationship of a new PET image parameter, (18)F-fluorodeoxyglucose ((18)F-FDG) uptake heterogeneity assessed by texture analysis, with maximum standardized value (SUV(max)) and tumor TNM staging.Forty consecutive patients esophageal squamous cell carcinoma were enrolled. All underwent whole-body preoperative (18)F-FDG PET/CT. Heterogeneity intratumoral was on basis textural features (entropy energy) three-dimensional images using MATLAB software. The correlations between...
Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis. However, the factors that mediate this mechanism have yet completely elucidated. In study, we isolated CD13+CD44+ sphere (SCs) derived from tissues SK-Hep-1 cells, which possessed cell-like properties. Through cytokine array analysis, growth differentiation factor 15 (GDF15) was significantly increased SCs. Clinical data showed GDF15 overexpressed positively related pathological grading....
// Yuting Huang 1,2,* , Meng Zhao 2,* Haixu Xu 2 Ke Wang 1 Zheng Fu Yuan Jiang and Zhi Yao Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center of Cancer, Key Laboratory Prevention Therapy, Tianjin, P.R. China Department Immunology, Cellular Molecular Educational Ministry China, School Basic Sciences, University, * These authors contributed equally to this work Correspondence: Yao, email: Keywords : ovarian cancer, RASAL2, EMT, MAPK, metastasis Received May...
Commensal intestinal bacteria play key roles in regulating host immune tolerance; however, bacterial strains and related metabolites directly involved this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different antibiotic treatment, Enterobacter ludwigii, abundant microbiota mice treated metronidazole, is screened out to have prophylactic therapeutic effects on DSS-induced or without the presence complex bacteria. E....
p85/p110 phosphoinositide 3-kinases regulate multiple cell functions and are frequently mutated in human cancer. The p85 regulatory subunit stabilizes inhibits the p110 catalytic subunit. minimal fragment of capable regulating is N-terminal SH2 domain linked to coiled-coil iSH2 (referred as p85ni). We have previously proposed that conformationally rigid tethers p85, facilitating interactions between nSH2 domain. In an oncogenic mutant murine truncation at residue 571 leads constitutively...
The present study estimated the biodistribution and radiation-absorbed dose of epidermal growth factor receptor (EGFR) radioligand <sup>11</sup>C-PD153035 in whole-body PET examinations healthy volunteers. <b>Methods:</b> Two-dimensional was performed on 9 subjects after injection at 329.3 ± 77.8 MBq (mean SD). A total 12 frames were acquired for approximately 90 min 7 segments body. Regions interest drawn images source organs. Residence time calculated as area under time–activity curve....
This study aimed to examine the differences in anxiety and depression between infertile Chinese couples diverse stages of vitro fertilization-embryo transfer (IVF-ET) their relationship with IVF-ET outcomes.From February 2016 December 2018, a total 247 that were undergoing randomly selected for this study. On day they started treatment (T1), human chorionic gonadotropin was administered (T2), 4 days after embryo (T3), self-designed questionnaires, Self-Rating Anxiety Scale, Depression Scale...
Purpose: To evaluate the efficacy of dual-time-point F-18 fluorodeoxyglucose positron emission tomography (FDG PET)/ computed (CT) for mediastinal nodal staging in non-small-cell lung cancer patients with comorbidity. Materials and Methods: Fifty-three pathologically proven pulmonary comorbidity 49 as controlled group without were enrolled. PET/CT was performed at 1-hour (whole body) post-FDG injection repeated 2 hours (thoracic) after injection. All received radical surgery system lymph...