A5101514984- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Mechanisms and Therapy
- Cardiac Structural Anomalies and Repair
- Reconstructive Facial Surgery Techniques
- Neutropenia and Cancer Infections
- Chromatin Remodeling and Cancer
- Breast Implant and Reconstruction
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Oxidative Organic Chemistry Reactions
- Reconstructive Surgery and Microvascular Techniques
- Adrenal and Paraganglionic Tumors
- Vasculitis and related conditions
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Shandong First Medical University
2019-2022
Shandong Provincial QianFoShan Hospital
2022
Shandong Tumor Hospital
2019-2021
Academy of Medical Sciences
2020-2021
Shanghai Changzheng Hospital
2021
Jining Medical University
2021
Shandong University
2019-2021
Wuhan University of Technology
2019
Heterogeneity is found in the tumor microenvironment among different pathological types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an important tracer for non-invasive imaging microenvironment, can be used to evaluate expression FAP cancer-associated fibroblasts, macrophages, and cells. Our aim was explore ability [18F]AlF-NOTA-FAPI-04 positron emission tomography (PET)/computed (CT) distinguish lung cancer by evaluating uptake this primary metastatic...
Abstract Background PD-L1 inhibitors is widely applied in lung adenocarcinoma patients. Tumor cells with high expression could trigger immune evasion. Cancer stem (CSCs) can evade from immunesurveillance due to their immunomodulating effects. However, the correlation between CSC and some immune-related markers seldom reported patients adenocarcinoma. Therefore, we aimed ascertain association Methods We assessed CD44 its adenocarcinoma, using Immune Estimation Resource (TIMER), which was...
Background Small-cell lung cancer (SCLC) is a malignant with the ability to metastasize quickly. The relationship between tumor size and distant metastasis patterns of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) has not been reported. Objectives aim this study was determine different as they related in ES-SCLC. Patients Methods We used Surveillance, Epidemiology, End Results (SEER) population-based data collected from 2010 through 2013 identify 11058 ES-SCLC patients definite evidence...
Transition metal-free and metal-catalyzed reactions using aryl(trifluoroethyl)iodonium salts as the trifluoroethylation reagents are summarized in this review.A large number of different types N-, O-, S-, C-nucleophiles were readily trifluoroethylated these under mild conditions.The results revealed that possess much higher electrophilic reactivity than other CH 2 CF 3 sources.Especially, bis(trifluoromethanesulfonyl)amides stable slightly soluble water, which successfully applied aqueous...
Background: Pulmonary sarcomatoid carcinoma (PSC) is a rare and distinct subtype of lung cancer characterized by its aggressiveness dismal prognosis. However, genomic landscape immune contexture have not been fully elucidated among PSC patients. Methods: In the present study, whole-exome-sequencing (WES) analyses were performed to depict 38 independent samples. Tumor mutation burden (TMB) was calculated with total number non-synonymous SNVs indel variants per megabase coding regions. PD-L1...
Abstract BackgroundBreast reconstruction is widely used for women undergoing mastectomy. Prosthetic implants have become a common technique performed these because of their safety, flexibility and adjustable size. There are few reports implant-associated squamous cell carcinoma. In addition to this report, only 8 including 11 cases been reported in the English literature.Case presentationWe report case patient with breast prosthetic carcinoma who received mastectomy 10 years ago. She was...
In this study, we aimed to establish a novel nomogram model which was better than the current American Joint Committee on Cancer (AJCC) stage predict survival for non-small-cell lung cancer (NSCLC) patients who underwent surgery. Patients and Methods. 19617 with initially diagnosed NSCLC were screened from Surveillance Epidemiology End Results (SEER) database between 2010 2015. These randomly divided into two groups including training cohort validation cohort. The Cox proportional hazard...
Small-cell lung cancer (SCLC) is an exceptionally lethal malignancy characterized by extremely high alteration rates and tumor heterogeneity, which limits therapeutic options. In contrast to non-small-cell that develops rapidly with precision oncology, SCLC still remains outside the realm of medicine. No recurrent actionable mutations have been detected. Additionally, a paucity substantive specimens has made it even more difficult classify subtypes based on genetic background. We therefore...
Aim: To verify the relationship between ARID1A and tumor immune microenvironment thus checkpoint inhibitors (ICIs) response. Material & methods: Several public databases were used to characterize association gene alteration immunity. Results: The mutation frequency was 8.2% in all cancer types. ARID1A-mutated cancers have higher scores of count, mutational burden, neoantigen load (p < 0.001) T cell repertoire, B repertoire diversity 0.05). has tight with multiple-activated cells. Survival...
Background: Combined small cell lung cancer (c-SCLC) distinguishes itself from (SCLC) due to its inclusion of both SCLC and non-small (NSCLC) components.Few studies have compared clinicopathological characteristics, prognosis factors affecting survival.We therefore addressed the issues in this study.Patients Methods: A total 400 c-SCLC 20,841 patients were enrolled using SEER database.Difference characteristics was analyzed chi-square.Kaplan-Meier applied compare their survival before after...
This study aimed to investigate the application of number positive lymph nodes (PLNs) in tumor, node, metastasis (TNM) staging system non-small cell lung cancer (NSCLC) patients. Patients and Methods. We screened a total 15820 patients with resected NSCLC between 2004 2015 from SEER database. The X-tile model was used determine cutoff values PLNs. Overall survival (OS) curves were plotted using Kaplan-Meier method, differences among individual groups defined log-rank test. Cox regression...
Background At present, there is a lack of studies focusing on the survival prediction patients with non-small cell lung cancer (NSCLC) receiving atezolizumab in light gene mutation characteristic. Methods Patients NSCLC from OAK study were defined as training group. LASSO Cox regressions applied to establish signature model predict overall (OS) rate POPLAR testing group validate model. In addition, we compared OS between and docetaxel classified according their risk score based our Results...
Abstract Objective A nomogram model based on clinical variables was conducted to predict the survival in patients with non‐small cell lung cancer (NSCLC) receiving second‐line atezolizumab. Methods Four hundred and twenty‐four NSCLC atezolizumab from OAK study were regarded as training cohort. Next, a cohort established of The concordance index, area under curve (AUC), calibration plots used assess performance model. In addition, 144 POPLAR test validate Using Kaplan–Meier log‐rank test, we...
Background As a rare subtype of primary lung adenocarcinoma (LUAD), mucinous pulmonary (MPA) was considered distinctive entity with unfavorable outcomes. Therefore, there is great need for better understanding the genomic and immunological landscape this tumor type, which would inform improved therapeutic strategies. Methods A total 96 patients histologically confirmed MPA were recruited from Shandong Cancer Hospital Institute (SCH). Single nucleotide variation (SNV), copy number (CNV),...
Purpose To assess risk of developing ocular complications in privately insured US patients with persistent non-anterior NIU compared to matched controls without uveitis. Methods Adults 18–64 years old ≥2 ICD-9-CM claims for intermediate-, posterior- or pan-NIU were identified (OptumHealth, 01/01/1998–31/03/2012), and those ≥90 days corticosteroids, immunosuppressants, and/or biologics use defined as cases. Cases 1:1 by sex, age, region, company, employment status, index date controls. Risks...