Despite the emerging insights into many snoRNAs (small nucleolar RNAs) which are detectable in body fluids and serve as noninvasive biomarkers, few studies have previously discussed role of tumor-educated platelets (TEPs). Herein, we systematically estimated dysregulation non-small cell lung cancer (NSCLC) clarified biomarker potential SNORD55 platelets.We compared expression between NSCLC normal tissues using SNORic datasets. Platelets were isolated from plasma low-speed centrifugation...

Exosomes derived from cancer cells encapsulate various kinds of tumor-specific molecules and thus can interact with adjacent or distant to mediate information exchange. Long non-coding RNAs (lncRNAs) in exosomes have the potential as diagnostic prognostic biomarkers different types cancers. The current study was aimed identify circulating exosomal lncRNAs for diagnosis colorectal (CRC). were isolated serum by ultracentrifugation verified transmission electron microscope (TEM), qNano,...

Abstract Background To date, no study has systematically explored the potential role of serum metabolites and lipids in diagnosis small cell lung cancer (SCLC). Therefore, we aimed to conduct a case-cohort that included 191 cases SCLC, 91 patients with adenocarcinoma, 82 squamous carcinoma, 97 healthy controls. Methods Metabolomics lipidomics were applied analyze different these patients. The SCLC model (d-model) was constructed using an integrated machine learning technology training cohort...

Early and differential diagnosis of Alzheimer's disease (AD) is a problem that puzzled many doctors. Reliable markers in easy-assembling samples are considerable clinical diagnostic value. In this work, laser Raman spectroscopy (LRS) was developed new method potentially allows early AD from the platelet sample. spectra platelets isolated different ages transgenic mice non-transgenic controls were collected analyzed. Multilayer perceptron networks (MLP) classification used to classify...

Abstract Background Accumulating evidence has confirmed the role of snoRNAs in a variety cancer, but rare renal cell carcinoma (RCC). This study aims to clarify RCC tumorigenesis and their potential as novel tumor biomarkers. Materials methods The snoRNA expression matrix was obtained from public TCGA SNORic databases. SNORD15A, SNORD35B SNORD60 were selected validated by qPCR, then analyzed combined with related clinical factors using T-test ROC curve. Results All three snoRNAs:...

Abstract Background Increasing evidence has demonstrated that snoRNAs play crucial roles in tumorigenesis of various cancer types. However, researches on ccRCC were very little. This study mainly aimed to validate the differential expression and potential diagnostic value SNORD63 SNORD96A ccRCC. Methods SnoRNAs was downloaded from SNORic TCGA database including 516 patients with 71 control cases. further detected 54 tumor adjacent FFPE tissues, 55 plasma 75 urinary sediment patients. Then,...

Abstract Background Most of hepatocellular carcinoma (HCC) arises on the background chronic inflammation. The presence infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. influence white blood cell (WBC) subtype counts HCC remains unclear. Methods In this study, we performed a Mendelian randomization (MR) study validation two datasets. summary data for WBC were extracted from recent large GWAS individuals European ancestry....

Ischemia-reperfusion injury (IRI), an innate immunity-driven local inflammation, remains the major problem in clinical organ transplantation. T cell immunoglobulin and mucin domain (TIM-3)-Galectin-9 (Gal-9) signaling regulates CD4+ Th1 immune responses. Here, we explored TIM-3-Gal-9 function a clinically relevant murine model of hepatic cold storage orthotopic liver transplantation (OLT). C57BL/6 livers, preserved for 20 h at 4°C UW solution, were transplanted to syngeneic mouse recipients....

Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo mature seeds Nelumbonaceae and exhibits therapeutic functions noteworthy anti-tumor effects in recent studies. However, potential property underlying mechanisms liensinine nonsmall-cell lung cancer (NSCLC) have not been illustrated. In this study, we demonstrated that has property, it could inhibit growth NSCLC vitro vivo. addition, found although induced significant accumulation autophagosomes, quench...

Neutrophils play a key role in the occurrence and development of cancer. However, relationship between neutrophils cancer prognosis remains unclear due to their great plasticity diversity. To explore effects on clinical outcome bladder cancer, we acquired analyzed gene expression data information patients from IMvigor210 cohort The Cancer Genome Atlas dataset (TCGA) database. We established neutrophil-based prognostic model incorporating five neutrophil-related genes (EMR3, VNN1, FCGRT,...

This study aimed to evaluate the feasibility and prognostic accuracy of incorporating number positive lymph nodes (PLN) into TNM staging system for non-small cell lung cancer (NSCLC) patients.We screened a total 9539 patients with resected stage IA-IIIB between 2010 2015 from SEER database. The chi-square test was used compare patient baseline characteristics X-tile model applied determine cut-off values PLN (nN). screen three different including nN = 0, nN1-3 nN4-. Univariate multivariate...

Surgery is commonly recommended for patients with stage I small-cell lung cancer (SCLC), whereas chemotherapy and radiotherapy are considered the standard treatment III SCLC. However, recent studies have suggested that a small proportion of SCLC at an advanced may benefit from surgical resection. Therefore, in this study, we investigated effectiveness surgery Patients were selected Surveillance, Epidemiology, End Results (SEER) database between 2004 2013. Propensity score matching (PSM) was...

The application of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer has significantly improved patient survival. However, most patients fail to respond ICIs or develop drug resistance during treatment. Therefore, novel biomarkers are needed predict the efficacy provide clues on how overcome resistance. Here, it was revealed that division cycle 25C ( CDC25C ) expression upregulated adenocarcinoma (LUAD) compared normal tissue multiple databases. This further verified by...

Although immune checkpoint inhibitors (ICIs) generally show poor therapeutic efficacy in patients with epidermal growth factor receptor (EGFR) mutations, certain research indicate that a small proportion of these do respond to ICIs. The present study sought identify the features EGFR mutations who might benefit from ICIs multiple studies and discussed optimal treatment paradigm for advanced non-small cell lung cancer (NSCLC) mutations. profiles 114 NSCLC received were retrospectively...

Aim: In this study, we evaluated the association between tumor location and prognosis in non-small-cell lung cancer patients. Patients & methods: The SEER database was used to screen for suitable patients using our inclusion criteria. χ2 test compare baseline patient characteristics Kaplan–Meier method as well log-rank were survival differences. At last, univariate multivariate Cox proportional hazards regression models analyze influence of different variables on overall survival. Results:...

This study was aimed to investigate the application of SARS-CoV-2 IgM and IgG antibodies in diagnosis COVID-19 infection.This enrolled a total 178 patients at Huangshi Central Hospital from January February 2020. Among them, 68 were infected, confirmed with nucleic acid test (NAT) CT imaging. Nine suspected group (NAT negative) fever other respiratory symptoms. 101 control diseases negative infection. After serum samples collected, tested by chemiluminescence immunoassay (CLIA) for all...

H-type hypertension, which is a specific form of hypertension characterized by elevated plasma homocysteine (Hcy) levels, has become major public health challenge worldwide. This study investigated the hypotensive effects and underlying mechanisms Huotan Jiedu Tongluo decoction (HTJDTLD), highly effective traditional Chinese medicine formula commonly used to treat vascular stenosis. Methionine was induce in rats, HTJDTLD administered intragastrically. Then, systolic diastolic blood pressures...

There is a desperate for the identification of more accurate and efficient biomarkers ICI responses in patients with SCLC.

The aim of the present study was to investigate prognostic impact RT on patients with extensive stage small cell lung cancer (ES‑SCLC) and distant metastasis. Using Surveillance Epidemiology End Results (SEER) database, 8,595 ES‑SCLC exhibiting metastasis treated between 2010 2013 were identified. Patient baseline characteristics compared using χ2 test. Kaplan‑Meier test used analyze subgroup cancer‑specific survival (CSS) rate, differences a log‑rank Univariate multivariate Cox regression...