A5038348765- Antiplatelet Therapy and Cardiovascular Diseases
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Nitric Oxide and Endothelin Effects
- Breast Implant and Reconstruction
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Venous Thromboembolism Diagnosis and Management
- Ginseng Biological Effects and Applications
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Vasculitis and related conditions
- Oral and Maxillofacial Pathology
- Otitis Media and Relapsing Polychondritis
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Genomics, phytochemicals, and oxidative stress
- Receptor Mechanisms and Signaling
- Galectins and Cancer Biology
- Lipoproteins and Cardiovascular Health
- Natural Antidiabetic Agents Studies
- Analytical Methods in Pharmaceuticals
- Plant-based Medicinal Research
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
Shandong First Medical University
1991-2025
Jinan Central Hospital
2024
Tianjin Fourth Central Hospital
2024
Peking University People's Hospital
2015-2023
Peking University
2015-2023
Minzu University of China
2023
Shandong Tumor Hospital
1991-2022
Loyola University Medical Center
1997-1998
Loyola University Chicago
1996
Nonalcoholic fatty liver disease (NAFLD) usually includes NAFL called simple hepatosteatosis and nonalcoholic steatohepatitis (NASH) more steatohepatitis. The latter is a leading pathogenic promotor of hepatocellular carcinoma (HCC). Phytochemical gallic acid (GA) has been proved to exert positive efficacy in HCC our work, but it remains unclear whether its hepatoprotective effect attributes the controlled transition from steatosis steatohepatitis.This work aims provide mechanistic evidence...
Microbubbles and contrast-enhanced ultrasound (CEUS) is a new technique for locating sentinel lymph node (SLN). The aim of this study to explore the feasibility SLNs tracing by CEUS using microbubbles in breast cancer patients value enhancing patterns diagnosing nodes metastases. A clinical trial was registered (trial registration: ChiCTR-DDT-13003778). One hundred one consecutive consenting with undergoing SLN biopsy were enrolled. Before surgery, microbubble injected periareolarly....
Background: Type 2 diabetes mellitus (T2DM) poses a huge threat to population health globally, and more drugs need be explored for treatment. In this study, we investigated the mechanism of active ingredient catalpol in Rehmannia glutinosa on reduces blood glucose diabetic. Methods: The T2DM model was constructed by intraperitoneal injection streptozotocin into Sprague-Dawley (SD) rats, which were randomly grouped group, pioglitazone high-dose low-dose group normal control group.The...
Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo mature seeds Nelumbonaceae and exhibits therapeutic functions noteworthy anti-tumor effects in recent studies. However, potential property underlying mechanisms liensinine nonsmall-cell lung cancer (NSCLC) have not been illustrated. In this study, we demonstrated that has property, it could inhibit growth NSCLC vitro vivo. addition, found although induced significant accumulation autophagosomes, quench...
Cellular DNA content from 30 patients with cervical carcinoma was determined using flow cytometry before and after radiation therapy (RT). The authors attempted to correlate changes in content, tumor response RT, post-RT pathologic findings. Before tumors eight of (26.7%) were diploid or near-diploid; 22 (73.3%) aneuploid. After near-diploid found 23 (76.7%), aneuploid observed seven (23.3%). Aneuploidy disappeared 15 the patient tumors, complete (CR) 13 these (86.7%). Pathologic...
We investigated the reliability of core needle biopsy (CNB) in evaluating status hormone receptor (HR), human epidermal growth factor (HER)-2, and Ki-67 status, effect neoadjuvant chemotherapy (NAC) on expression these immunohistochemical markers.Among 177 patients with breast adenocarcinoma, 95 underwent NAC remaining 82 made up control group. Immunohistochemistry (IHC) was used to evaluate estrogen (ER), progesterone (PR), HER-2, specimens obtained by surgical excision or CNB.In group, ER,...
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of total heart patients and is characterized by peripheral circulation, cardiac remodelling comorbidities (such as advanced age, obesity, hypertension diabetes) limited treatment options. Chidamide (HBI-8000) a domestically produced benzamide-based histone deacetylase isoform-selective inhibitor used the relapsed refractory T-cell lymphomas. Based on our in vivo studies, we propose that HBI-8000 exerts its...
Two phase I studies in healthy Chinese (NCT01458743) and Western (NCT01612507) subjects evaluated the pharmacokinetics (PK) safety of single multiple ceftaroline fosamil 600 mg infusions administered every 8 or 12 hours (q8h q12h).Each study enrolled sequentially into 1 2 cohorts (cohort 1: 60-minute infusions; cohort 2: 120-minute infusions). All (n = 26) received open label fosamil; study, 41) each were randomized 3 : to placebo infusions. Single on days 8. On - 7 (3 for 1) q12h q8h Plasma...
The aim of this study was to investigate the feasibility sentinel lymph node biopsy (SLNB) after neoadjuant chemotherapy (NAC) in breast cancer patients with confirmed axillary nodal metastases.We enrolled 51 who received NAC. All were proven have metastases by histopathology prior They all underwent SLNB before surgery, and complete dissection immediately followed.The identification rate for 87.5% (84/96); false negative 24.5% (12/49). clinicopathological factors not significantly...
Limonin shows promise in alleviating non-alcoholic fatty liver disease. We investigated the mechanisms of limonin against steatohepatitis (NASH) using network pharmacology and molecular docking.Public databases provided NASH- limonin-associated targets. VennDiagram identified potential targets for NASH. Enrichment analysis explored limonin-NASH relationship. PPI analysis, CytoHubba models, bioinformatics hub genes NASH treatment. Molecular docking assessed limonin's binding ability to...
Giant cell arteritis (GCA) is a kind of systemic vasculitis affecting individuals over 50 years old and often the cause new-onset headaches in older adults. Patients with GCA sometimes have rheumatic polymyalgia (PMR). The diagnosis generally depends on clinical manifestation, elevated erythrocyte sedimentation rate (ESR) or C-reactive protein, positive imaging findings commonly obtained by ultrasound temporal artery biopsy. In this study, we report case an 83-year-old woman headache ESR....