A5088214633- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Analysis
- Traditional and Medicinal Uses of Annonaceae
- Kruppel-like factors research
- Marine Sponges and Natural Products
- Adipose Tissue and Metabolism
- Synthesis of Organic Compounds
- Plant Diversity and Evolution
- Fibroblast Growth Factor Research
- Multiple Myeloma Research and Treatments
- Ethnobotanical and Medicinal Plants Studies
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bioactive natural compounds
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Chromatography in Natural Products
- Wood and Agarwood Research
- Microbial Metabolism and Applications
- Nutrition and Health in Aging
- Photochromic and Fluorescence Chemistry
University of Chinese Academy of Sciences
2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
The Affiliated Hospital to Changchun University of Chinese Medicine
2024
Changchun University of Chinese Medicine
2013-2021
Second Affiliated Hospital of Chongqing Medical University
2015
National Cerebral and Cardiovascular Center
2015
Shandong University of Traditional Chinese Medicine
2015
Columbia University Irving Medical Center
2015
Dalian Medical University
2015
Adenoviral E1A binding protein 300 kDa (p300) and its closely related paralog CREB (CBP) are promising therapeutic targets for human cancer. Here, we report the first discovery of novel potent small-molecule PROTAC degraders p300/CBP against hepatocellular carcinoma (HCC), one most common solid tumors. Based upon clinical bromodomain inhibitor CCS1477, a conformational restriction strategy was used to optimize linker generate series PROTACs, culminating in identification QC-182. This...
Skeletal muscle dysfunction and exercise intolerance are clinical hallmarks of patients with heart failure. These have been linked to a progressive catabolic state, skeletal inflammation, impaired oxidative metabolism. Previous studies suggest beneficial effects ω-3 polyunsaturated fatty acids glutamine on performance protein balance.In randomized double-blind, placebo-controlled trial, 31 failure were either l-alanyl-l-glutamine (8 g/d) acid (6.5 or placebo (safflower oil milk powder) for 3...
H-type hypertension, which is a specific form of hypertension characterized by elevated plasma homocysteine (Hcy) levels, has become major public health challenge worldwide. This study investigated the hypotensive effects and underlying mechanisms Huotan Jiedu Tongluo decoction (HTJDTLD), highly effective traditional Chinese medicine formula commonly used to treat vascular stenosis. Methionine was induce in rats, HTJDTLD administered intragastrically. Then, systolic diastolic blood pressures...
As a non-ligand-dependent activation protein, EGFRvIII is the most common mutant of EGFR, and its existence or especially nuclear translocation in tumors can exacerbate malignancy.Compared with which has been studied extensively, specific mechanism by undergoes not yet reported.Here, we found that eventually reached nucleus involvement Golgi endoplasmic reticulum (ER) glioma cells.In this process, syntaxin-6 was responsible for identification transport on Golgi.We also demonstrated COPI...
Abstract Cardiovascular‐related diseases continue to be a leading cause of death globally. Among ischemic‐induced cardiac diseases, myocardial infarction (MI) is reported an alarming value. Despite numerous improvements in the medical intrusions, still this armamentarium fails effective managing illness without setbacks. Ferruginol (FGL) major polyphenols and terpenoids with pharmacological activities including antioxidant anti‐inflammatory. Following, work was aimed explore cardio...
E1A binding protein (p300) is a promising therapeutic target for the treatment of cancer. Herein, we report discovery series novel inhibitors with an (
Abstract Objective The aim of this study is to investigate the role quercetin on coronary atherosclerosis and further explore its possible mechanisms. Methods Hematoxylin-eosin (H&E), Immunohistochemical (IHC) Aniline blue staining are analyze pathological changes aorta cross section. Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), Swiss Target Prediction PubChem used predict screen bioactive ingredients medicine (Haunglian, Yuxingcao Jinyinhua) for atherosclerosis....