A5100460830- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Statistical Methods in Clinical Trials
- Immune cells in cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Zoonotic diseases and public health
- Biological Stains and Phytochemicals
- Metal complexes synthesis and properties
- Biosimilars and Bioanalytical Methods
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- PARP inhibition in cancer therapy
Education Department of Heilongjiang Province
2025
Xuzhou Medical College
2021-2024
Shanghai East Hospital
2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2024
Shanghai Jiao Tong University
2020-2023
Huazhong University of Science and Technology
2005-2023
Wuhan Children's Hospital
2023
Shanghai Chest Hospital
2021-2023
Abstract Immunotherapies targeting the programmed death 1 (PD-1) coinhibitory receptor have shown great promise for a subset of patients with cancer. However, robust and safe combination therapies are still needed to bring benefit cancer immunotherapy broader patient populations. To search an optimal strategy combinatorial immunotherapy, we compared antitumor activity anti–4-1BB/anti–PD-1 that anti–PD-1/anti–LAG-3 in poorly immunogenic B16F10 melanoma model. Pronounced tumor inhibition...
Background Radioimmunotherapy has a promising antitumor effect in hepatocellular carcinoma (HCC), depending on the regulatory of radiotherapy tumor immune microenvironment. Ionizing radiation (IR)-induced DNA damage repair (DDR) pathway activation leads to inhibition microenvironment, thus impairing radioimmunotherapy. However, it is unclear whether DDR can enhance In this study, we aim explore role inhibitor AZD6738 combination and checkpoint inhibitors (ICIs) HCC. Methods C57BL/6 mouse...
Abstract Chemotherapy and radiotherapy predominantly improve the clinical outcomes of patients with human papillomavirus (HPV)-related head neck squamous cell carcinoma (HNSCC). Whether this superiority goes on when treated immune checkpoint inhibitors is still unclear. This study sought to determine predictive value potential mechanisms HPV status for treatment programmed death 1 (PD-1)/ligand 1(PD-L1) inhibitors. We conducted an integrated analysis relationships between PD-L1, tumor...
The coronavirus disease 2019 (COVID-19) has become a life-threatening pandemic. epidemic trends in different countries vary considerably due to policy-making and resources mobilization. We calculated basic reproduction number (R0) the time-varying estimate of effective reproductive (Rt) COVID-19 by using maximum likelihood method sequential Bayesian method, respectively. European North American possessed higher R0 unsteady Rt fluctuations, whereas some heavily affected Asian showed...
Background Despite great advances in the treatment of breast cancer, innovative approaches are still needed to reduce metastasis. As a minimally invasive local therapy (not standard for cancer), microwave ablation (MWA) has been attempted treat but effect and immune response induced by MWA have seldom reported. Methods The clinical study was performed determine complete rate early-stage cancer. Secondary endpoints included safety antitumor response. 35 subjects from this were enrolled...
Triple-negative breast cancer (TNBC), which accounts for 10%–20% of cases, is characterized by a higher metastasis rate, recurrence risk, and worse prognosis. Traditional treatments such as chemotherapy, surgery, radiotherapy have limited therapeutic effects. Although immune checkpoint blockade (ICB) therapy represented anti-programmed death 1 (aPD-1) antibody has made further progress in treating TNBC, its effect still not optimistic. Ataxia telangiectasia mutated (ATM) critical factor the...
Aim: We investigated a promising cooperative combination of radiotherapy (RT) and programmed death ligand 1 (PD-L1) monoclonal antibodies (mAb) in both local abscopal tumors. Materials & methods: C57BL/6 mice were randomly grouped received RT, α-PD-L1 mAb or therapy 13 days after implantation Lewis lung carcinoma cells. Flow cytometry immunohistochemistry analyses demonstrated CD8+ T-cell infiltration PD-L1 expression tumor issue. Cytometric bead arrays used to examine cytokine levels....
Background Colorectal cancer is a lethal worldwide. Due to the low tumor mutation burden and proportion of tumor-infiltrating lymphocytes in microenvironment most patients, innovative immunotherapeutic approaches need be identified. Methods Using TCGA-COAD dataset (n = 514), we identified TNFRSF11B as prognostic factor colon cancer. An immunohistochemistry (IHC) 86), 290 single colorectal cells (GSE81861), 31 paired transcriptional datasets were further applied validate function TNFRSF11B,...
(1) Background: Despite the fact that robotic-assisted thoracoscopic lobectomy (RATL) has been prevalently applied for early stage non-small cell lung cancer (NSCLC), its superiorities are still to be fully revealed patients with metastatic N1 lymph nodes (LNs). We aim evaluate advantages of RATL NSCLC. (2) Methods: This retrospective study identified consecutive pathological NSCLC undergoing RATL, video-assisted (VATL), or open (OL) in Shanghai Chest Hospital between 2014 and 2020. Further,...
Small cell lung cancer (SCLC) accounts for approximately 10-15% of all cancers. No significant improvement has been made patients with SCLC in the past several decades. The main progresses were thoracic radiation and prophylactic cranial irradiation (PCI) that improved patient survival rate. For limited disease good performance status (PS), concurrent chemoradiotherapy (CCRT) followed by PCI should be considered. extensive disease, combination etoposide platinum-based chemotherapy remains...
The challenge to improve the clinical efficacy and enlarge population that benefits from immune checkpoint inhibitors (ICIs) for non-small-cell lung cancer (NSCLC) is significant. Based on whole-exosome sequencing analysis of biopsies NSCLC patients before anti-programmed cell death protein-2 (PD-1) treatment, we identified NLRP4 mutations in responders with a longer progression-free survival (PFS). Knockdown mouse Lewis line enhanced interferon (IFN)-α/β production through...
Background: High levels of UV exposure are a significant factor that can trigger the onset and progression SKCM. Moreover, this is closely linked to malignancy tumor prognosis patients. Our objective identify biomarker database associated with exposure, which be utilized for prognostic analysis diagnosis treatment Methods: This study used weighted gene co-expression network analyses (WGCNA) mutation frequency screen UV-related target genes using GSE59455 cancer genome atlas databases (TCGA)....