A5100766649- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Bacterial Infections and Vaccines
- Infant Development and Preterm Care
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Streptococcal Infections and Treatments
- Metabolism and Genetic Disorders
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Atrial Fibrillation Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion channel regulation and function
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Kawasaki Disease and Coronary Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Pediatric Urology and Nephrology Studies
- Respiratory viral infections research
National Cheng Kung University Hospital
2015-2025
Luoyang Central Hospital Affiliated to Zhengzhou University
2019-2025
Nantong University
2024-2025
Taipei Medical University
2014-2024
Mackay Memorial Hospital
2013-2024
Tulane University
1967-2024
Tongji Hospital
2024
Luodong Poh-Ai Hospital
2024
Huazhong University of Science and Technology
2023-2024
Affiliated Hospital of Guizhou Medical University
2021-2024
Enterovirus 71 infection causes hand-foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting, ulcerative lesions the oral mucosa, vesicles on backs hands feet. The initial illness resolves but sometimes followed aseptic meningitis, encephalomyelitis, or even acute flaccid paralysis similar to paralytic poliomyelitis.
We studied the outcomes at school age in children who had participated a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy (initiated within 12 hours after birth) for prevention chronic lung disease prematurity.Of 262 included initial study, 159 lived to age. Of these children, 146 (72 group and 74 control group) were our study. All infants severe respiratory distress syndrome requiring mechanical ventilation shortly birth. In group, 0.25 mg per kilogram body...
Objectives. To study the outcome at 2-year corrected age of infants who participated in a double-blind controlled trial early (<12 hours) dexamethasone therapy for prevention chronic lung disease (CLD). Methods and Materials. A total 133 children (70 control group, 63 dexamethasone-treated group) survived initial period lived to 2 years were studied. All had birth weights 500 1999 g severe respiratory distress syndrome requiring mechanical ventilation within 6 hours after birth. For...
Abstract Purpose: The new classification announced by the World Health Organization in 2016 recognized five molecular subtypes of diffuse gliomas based on isocitrate dehydrogenase (IDH) and 1p/19q genotypes addition to histologic phenotypes. We aim determine whether clinical MRI can stratify these benefit diagnosis monitoring gliomas. Experimental Design: data from 456 subjects with were obtained Cancer Imaging Archive. Overall, 214 subjects, including 106 cases glioblastomas 108 lower grade...
An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent the younger than age 5 years. Hand-foot-and-mouth syndrome 79% children central nervous system (CNS) involvement 35%, including nine fatal cases. predominant neurological presentations myoclonus (68%), vomiting (53%), ataxia (35%). Brain stem encephalitis was cardinal feature CNS...
We report a new heart-on-chip design capable of electrical stimulation, recording growth, contraction and activating map from <italic>in vitro</italic>-cultured human cardiac tissues.
Diabetic retinopathy (DR) is a microvascular complication of diabetes and the leading cause vision loss in working-age adults. Recent studies have implicated complement system as player development vascular damage progression DR. However, role activation DR are not well understood. Exosomes, small vesicles that secreted into extracellular environment, cargo proteins plasma, suggesting they can participate causing associated with We demonstrate IgG-laden exosomes plasma activate classical...
EXamining everolimus In a Study of Tuberous sclerosis 3 (EXIST-3) demonstrated significantly reduced seizure frequency (SF) with vs placebo. this study, we evaluate the long-term efficacy and safety for tuberous complex (TSC)-associated treatment-refractory seizures.After completion core phase, patients could enter an open-label extension phase receive (target exposure, 3-15 ng/mL) ≥48 weeks. Efficacy end points included change from baseline in average weekly SF expressed as response rate...
Objective. To assess the usefulness of laboratory parameters, including peripheral white blood cell (WBC) count, C-reactive protein (CRP) concentration, erythrocyte sedimentation rate (ESR), and microscopic urinalysis (UA), for identifying febrile infants younger than 8 weeks age at risk urinary tract infection (UTI), comparison standard UA hemocytometer WBC counts predicting presence UTI. Methods. A total 162 children &lt;8 were enrolled in this prospective study. All underwent clinical...
The long-term effects of brief but repetitive febrile seizures (FS) on memory have not been as thoroughly investigated the impact single and prolonged seizure in developing brain. Using a heated-air FS paradigm, we subjected male rat pups to one, three, or nine episodes days 10 12 postpartum. Neither hippocampal neuronal damage nor apoptosis was noted within 72 hours after FS, there significant loss, aberrant mossy fiber sprouting, altered threshold pentylenetetrazol any group at adulthood....
Abstract Trisomy 18 is the second most common autosomal trisomy in newborns. The birth prevalence of this disorder approximately 1 3,000 to 8,000, and life span majority patients less than year. As information regarding outcome rather fragmentary literature, study aimed at investigating survival natural history 18. We also evaluated age management two different periods, before after implementation National Health Insurance (NHI) program. Thirty‐nine cases were collected Mackay Memorial...
Abstract Objective Perinatal inflammatory responses contribute to periventricular leukomalacia (PVL) and cerebral palsy (CP) in preterm infants. Here, we examined whether children with CP had altered when school‐aged. Methods Thirty‐two PVL‐induced (mean [±standard deviation] age, 7.2 ± 3.6 years) 32 control normal neurodevelopment (6.2 2.2 matched for gestational age were recruited. We measured tumor necrosis factor (TNF)‐α levels the plasma supernatants of peripheral blood mononuclear...
Abstract Background White matter injury is the major form of brain damage in very preterm infants. Selective white immature can be induced by lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) postpartum (P) day 2 rat pups whose maturation status equivalent to that infants less than 30 weeks gestation. Neuroinflammation, blood–brain barrier (BBB) and oligodendrocyte progenitor apoptosis may affect susceptibility LPS-sensitized HI injury. c-Jun N-terminal kinases (JNK) are important...
Abstract Hepatic stellate cells (HSCs) may play an important role in hepatic immune regulation by producing numerous cytokines/chemokines and expressing Ag-presenting T cell coregulatory molecules. Due to disruption of the endothelial barrier during cold-ischemic storage reperfusion liver grafts, HSCs can interact directly with system. Endotoxin (LPS), levels which increase diseases transplantation, stimulates synthesis many mediators HSCs. We hypothesized that LPS-stimulated might promote...
In very preterm infants, white matter injury is a prominent brain injury, and hypoxic ischemia (HI) infection are the two primary pathogenic factors of this injury. Microglia microvascular endothelial cells closely interact; therefore, common signaling pathway may cause neuroinflammation blood–brain barrier (BBB) damage after to immature brain. CXC chemokine ligand 5 (CXCL5) produced in inflammatory by various organs response insults. CXCL5 levels markedly increased amniotic cavity...
Activation of pro-inflammatory and pro-angiogenic pathways in the retina bone marrow contributes to pathogenesis diabetic retinopathy. We identified miR-15a as key regulator both through direct binding inhibition central enzyme sphingolipid metabolism, ASM, growth factor, VEGF-A. was downregulated cells. Over-expression downregulated, upregulated ASM VEGF-A expression retinal In addition effects, migration vascular repair function impaired inhibitor-treated circulating angiogenic cells...
Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompanied by CNS inflammation, neurotoxicity, blood-brain barrier destruction. Microglial cells surrounding the blood vessels injured hippocampus regions activated DENV infection....