A5006706109- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Heat shock proteins research
- RNA Research and Splicing
- Axon Guidance and Neuronal Signaling
- Genomics and Chromatin Dynamics
- Genetic Neurodegenerative Diseases
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Tuberous Sclerosis Complex Research
- RNA Interference and Gene Delivery
Taipei Medical University
2014-2025
University at Buffalo, State University of New York
2025
National Health Research Institutes
2019-2025
Chung Shan Medical University Hospital
2023
National Cheng Kung University
1995-2021
Kun Shan University
2012-2019
Institute of Pharmacology
2018
Institute of Molecular Biology and Biophysics
2014
Institute of Biomedical Sciences, Academia Sinica
1996-2013
National Taipei University
2008
Loss of the maintenance genetic material is a critical step leading to tumorigenesis. It was reported that overexpression Aurora-A and constitutive activation epidermal growth factor (EGF) receptor (EGFR) are implicated in chromosome instability. In this study, we examined when cells treated with EGF result centrosome amplification microtubule disorder, which for Interestingly, expression also increased by stimulus. An immunofluorescence assay indicated can induce nuclear translocation EGFR....
Abstract Huntington's disease (HD) is an autosomal dominant neurodegenerative caused by a CAG trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. We show herein that HD transgenic mouse model (R6/2), daily administration CGS21680 (CGS), A 2A adenosine receptor (A ‐R)‐selective agonist, delayed progressive deterioration motor performance and prevented reduction brain weight. 3D‐µMRI analysis revealed CGS reversed enlarged ventricle‐to‐brain ratio R6/2 mice, with particular...
MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target potential role AKI are unknown. Here, we found that microRNA-494 binds to the 3'UTR activating transcription factor 3 (ATF3) decreases transcription. In mice, overexpression significantly attenuated level ATF3 induced inflammatory mediators, such as IL-6, monocyte chemotactic protein-1, P-selectin, after ischemia/reperfusion, exacerbating further decreasing function. Activation NF-κB mediated this...
Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompanied by CNS inflammation, neurotoxicity, blood-brain barrier destruction. Microglial cells surrounding the blood vessels injured hippocampus regions activated DENV infection....
5-Hydroxymethyl-2-furaldehyde (HMF), a ubiquitous food contaminant, has been proposed to be metabolically activated through sulfonation of its allylic hydroxyl functional group. In support this idea, we have found the strong direct mutagenicity chemically synthesized sulfuric acid ester, 5-sulfooxymethylfurfural (SMF), in Salmonella typhimurium TA104. The intrinsic reactive ester was significantly inhibited by glutathione and S-transferase activity dialyzed rat liver cytosol. metabolic...
Vascular endothelial growth factor (VEGF) is a mediator of airway inflammation and remodelling in asthma. Transforming (TGF)-β 1 plays pivotal roles diverse biological processes, including tissue repair number chronic lung diseases. However, there are few studies elucidating the interactions between VEGF TGF-β allergic disease. A murine model disease was used to define mechanism by which induces subepithelial fibrosis investigate potential relationship mechanisms signalling regulates...
Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cell migration through its influence on focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by in a dose dependent manner. Our results identified new mechanism action for indomethacin: inhibition...
In the central nervous system regions of sporadic and familial FTLD ALS patients, TDP-43 has been identified as major component UBIs inclusions which is abnormally hyperphosphorylated, ubiquitinated, cleaved into C-terminal fragments to form detergent-insoluble aggregates. So far, effective drugs for neurodegenerative diseases are yet be developed. Autophagy demonstrated metabolism route pathological inclusions, hence activation autophagy a potential therapeutic strategy pathogenesis in ALS....
Ovarian cancer has a poor prognosis. Most patients are diagnosed with ovarian when the disease reached an advanced stage and cure rates generally under 30%. Hence, early diagnosis of is best means to control in long term abate mortality. So far, antigen 125 (CA125) human epididymis protein 4 (HE4) gold-standard tumor markers for cancer; however, these two can be elevated number conditions unrelated cancer, resulting decreased specifically positive predictive value. Therefore, it urgent...
Huntington's disease is a neurodegenerative resulting from CAG (glutamine) trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. The role striatum-enriched A2A adenosine receptor (A2A-R) has attracted much attention lately. In present study, we found that expression mutant Htt with expanded poly(Q) significantly reduced transcript levels endogenous A2A-R PC12 cells and primary striatal neurons. Cotransfection various promoter constructs gene an construct poly(Q)-expanded revealed...
Retinoid signaling plays a crucial role in patterning rhombomeres the hindbrain and motor neurons spinal cord during development. A fundamentally interesting question is whether retinoids can pattern functional organization forebrain that generates high order of cognitive behavior. The striatum contains compartmental structure striosome (or “patch”) intervening matrix. How this highly complex mosaic design patterned by genetic programs development remains elusive. We report developmental...
The canonical Wnt/β-catenin pathway is constitutively activated in more than 90% of colorectal cancer (CRC) cases which β-catenin contributes to CRC cell growth and survival. In contrast the pathway, non-canonical Wnt can antagonize functions pathway. Wnt5a a key factor it plays diverse roles different types cancers. It was shown that reintroducing into cells resulted inhibited proliferation impaired motility. However, contradictory results were reported describing increased expression being...
The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during development. Downregulation of Znf179 has been observed in motor neurons adult mouse models amyotrophic lateral sclerosis (ALS), yet the molecular function neurodegeneration never previously described. contains classical C3HC4 domain, and numerous proteins containing domain act as E3 ubiquitin ligases. Hence, we are interested identify whether possesses ligase...
Abstract Purpose: The molecular targets for castration-resistant prostate cancer (CRPC) are unknown because the disease inevitably recurs, and therapeutic approaches patients with CRPC remain less well understood. We sought to investigate regulatory mechanisms that result in increased resistance, which is associated neuroendocrine differentiation of linked dysregulation androgen-responsive pathway. Experimental Design: underlying intracellular mechanism sustains oncogenic network involved...
Abstract Activated microglial cells are present in dengue virus (DENV)-infected brains; however, the possible effects of DENV on microglia remain unclear. Here, we demonstrated caused infection, including viral entry, RNA replication, protein expression, and release, murine cell line BV2. infection an increase formation multipolar phenotype vitro vivo without affecting growth cytotoxicity. considerably increased motility disrupting either actin filaments or clathrin retarded such effect....
Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation clinical implications over-expressed cells are unclear. Here we show that elevated increases proliferation, transformation migration cells. Importantly, kinase activity is required for these tumour-associated properties. Analysis specimens shows expression increased cervical cancer, highly correlated with staging cancer. Over-expressed AURKC-GFP...