A5042905323- Cardiovascular and exercise physiology
- Mesoporous Materials and Catalysis
- Sports Performance and Training
- Congenital Heart Disease Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Zeolite Catalysis and Synthesis
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Cardiac Fibrosis and Remodeling
- Sports injuries and prevention
- Protein Tyrosine Phosphatases
- Coffee research and impacts
- Effects of Vibration on Health
- Exercise and Physiological Responses
- Ion channel regulation and function
- Coronary Artery Anomalies
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Effects of Exercise
- Inflammasome and immune disorders
- Ion Transport and Channel Regulation
- Cardiac electrophysiology and arrhythmias
Taipei Tzu Chi Hospital
2010-2024
Tzu Chi University
2015-2024
Institute of Biomedical Sciences, Academia Sinica
2014-2024
National Taiwan Normal University
2012-2024
Buddhist Tzu Chi Medical Foundation
2018-2022
Mahosot Hospital
2022
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
2022
University of Oxford
2022
Academia Sinica
2003-2020
Hualien Tzu Chi Medical Center
2017-2019
Cypher is a member of recently emerging family proteins containing PDZ domain at their NH2 terminus and one or three LIM domains COOH terminus. knockout mice display severe form congenital myopathy die postnatally from functional failure in multiple striated muscles. Examination muscle the mutants revealed that not required for sarcomerogenesis Z-line assembly, but rather maintenance during function. In vitro studies demonstrated individual within localize independently to via interactions...
MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target potential role AKI are unknown. Here, we found that microRNA-494 binds to the 3'UTR activating transcription factor 3 (ATF3) decreases transcription. In mice, overexpression significantly attenuated level ATF3 induced inflammatory mediators, such as IL-6, monocyte chemotactic protein-1, P-selectin, after ischemia/reperfusion, exacerbating further decreasing function. Activation NF-κB mediated this...
A variety of stress stimuli, including ischemia-reperfusion (I/R) injury, induce the transcriptional repressor ATF3 in kidney. The functional consequences this upregulation after renal I/R injury are not well understood. Here, we found that ATF3-deficient mice had higher I/R-induced mortality, kidney dysfunction, inflammation (number infiltrating neutrophils, myeloperoxidase activity, and induction IL-6 P-selectin), apoptosis compared with wild-type mice. Furthermore, gene transfer to...
Transcriptional repressor activating transcription factor 3 (ATF3) is induced by various stress stimuli, including inflammation-induced renal injury. In addition, ATF3 also down-regulates adhesion molecules like intercellular molecule (ICAM), vascular cell (VCAM), and monocyte chemotactic protein-1 (MCP-1). However, the relation between up-regulated after ischemia/reperfusion (I/R) injury MCP-1 not completely understood. this study, we demonstrated that, in I/R inflammation, induction of...
Prediabetes is characterized by abnormal glycemic levels below the type 2 diabetes threshold, and effective control of blood glucose may prevent progression to diabetes. While association between gut microbiota, metabolism, insulin resistance in diabetic patients has been established previous studies, there a lack research regarding these aspects prediabetic Asia. We aim investigate composition microbiota their differences compared healthy individuals. In total, 57 60 adult individuals aged...
Endothelin-1 (ET-1) is implicated in fibroblast proliferation, which results cardiac fibrosis. Both reactive oxygen species (ROS) generation and epidermal growth factor receptor (EGFR) transactivation play critical roles ET-1 signal transduction. In this study, we used rat fibroblasts treated with to investigate the connection between ROS EGFR transactivation. treatment was found stimulate phosphorylation of generation, were abolished by ET<sub>A</sub> antagonist...
Background. Gentamicin, a widely used antibiotic for the treatment of bacterial infection, can cause nephrotoxicity. Tetramethylpyrazine (TMP) is compound purified from rhizome Ligusticum wallichi (called chuanxiong in Chinese). Besides its protection against ischaemia–reperfusion injury and nephritis mice, we previously reported that TMP reverses gentamicin-induced apoptosis rat kidneys. Haem oxygenase-1 (HO-1) induction by has also been shown to attenuate myocardial ischaemia/reperfusion...
Abstract Adiponectin (APN), a circulating adipose‐derived hormone that regulates inflammation and energy metabolism, has beneficial effects on the cardiovascular disorders. Serum APN levels are lower in patients with coronary artery disease higher chronic kidney disease. However, precise role of acute reno‐vascular is not clear. Results present study show serum concentration decreased after renal ischemia reperfusion (I/R) injury mice. In addition, I/R‐induced dysfunction (elevated...
Abstract Ischemia-reperfusion (I/R) induced acute kidney injury (AKI) is regulated by transcriptional factors and microRNAs (miRs). However, modulation of miRs has not been characterized in AKI. Here, we found that urinary miR-16 was 100-fold higher AKI patients. MiR-16 detected earlier than creatinine mouse after I/R. Using TargetScan, the 3′UTR B-cell lymphoma 2 (BCL-2) complementary to decrease fluorescent reporter activity. Overexpression mice significantly attenuated renal function...
Abstract Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning white adipose tissue has been suggested a potential strategy, but drug still needs to be identified. Here, genetic deletion activating transcription factor 3 ( ATF3 −/− ) in mice under high-fat diet (HFD) resulted obesity insulin resistance, which was abrogated by virus-mediated restoration. ST32da, synthetic inducer isolated from Salvia miltiorrhiza , promoted...
Resveratrol is a phytoestrogen naturally found in grapes and among the major constituents of wine thought to have cardioprotective effect. Endothelin-1 (ET-1) potent vasopressor synthesized by endothelial cells both culture vivo. The aims this study were test hypothesis that resveratrol may alter strain-induced ET-1 gene expression identify putative underlying signaling pathways cells. We show indeed potently inhibits secretion, mRNA level, promoter activity. also strain-increased NADPH...
Activating transcription factor 3 (ATF3), a cAMP response element-binding protein/ATF family factors member, has been implicated in the cardiovascular and inflammatory system is rapidly induced by ischemic-reperfusion injuries. We performed transverse aortic banding (TAB) experiments using ATF3 gene-deleted mice (ATF3<sup>−/−</sup>) wild-type (WT) to determine what effect it might have on heart failure pressure overloading. Compared with WT mice, ATF3<sup>−/−</sup> were found...
Isoflurane is a widely used anesthetic in clinical practice and animal experiments. It exerts cardioprotective effects by pre- postconditioning but also has dose-dependent cardiovascular side effects. In this article, we aim to characterize the hemodynamic of isoflurane. We pressure–volume catheter evaluate changes adult Sprague–Dawley rats (n = 6) given increasing concentrations inhaled isoflurane anesthesia. The concentration was started at 0.5% (baseline) gradually increased. Data on...