A5081937319- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Cancer Genomics and Diagnostics
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Renal cell carcinoma treatment
- Natural Compound Pharmacology Studies
- Genomics, phytochemicals, and oxidative stress
- Microtubule and mitosis dynamics
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Renal and related cancers
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2018-2024
Institute of Clinical Research
2023
Kaohsiung Municipal Hsiao-Kang Hospital
2023
National Cancer Institute
2005-2010
Center for Cancer Research
2005-2010
Frederick National Laboratory for Cancer Research
2007-2010
National Cheng Kung University
2010
Center for Environmental Health
2010
National Kaohsiung Marine University
2010
The STAT3 transcription factor is an important initiator of mammary gland involution in the mouse. This work shows that target gene CCAAT/enhancer binding protein delta (C/EBPδ) a crucial mediator pro-apoptotic expression events epithelial cells. In absence C/EBPδ, delayed, genes encoding p53, BAK, IGFBP5 and SGP2/clusterin are not activated, while anti-apoptotic coding for BFL1 Cyclin D1 repressed. Consequently, p53 targets such as survivin, BRCA1, BRCA2 BAX regulated appropriately protease...
The transcription factor CCAAT/enhancer binding protein δ (C/EBPδ, CEBPD, NFIL-6β) has tumor suppressor function; however, the molecular mechanism(s) by which C/EBPδ exerts its effect are largely unknown. Here, we report that induces expression of Cdc27 (APC3) subunit anaphase promoting complex/cyclosome (APC/C), results in polyubiquitination and degradation prooncogenic cell cycle regulator cyclin D1, also down-regulates B1, Skp2, Plk-1. In knockout mouse embryo fibroblasts (MEF) levels...
Recent evidence indicates that a tumor suppressor gene CEBPD (CCAAT/enhancer-binding protein delta) is downregulated in many cancers including cervical cancer, which provides therapeutic potential associated with its reactivation. However, little known for activators and the effect of reactivation transcription upon anticancer drug treatment. In this study, we identified novel activator, 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione (HMDB). The purpose study to characterize...
The combined effects of ling-zhi polysaccharide fraction 3 (LZP-F3) and anticancer drugs (cisplatin arsenic trioxide) were examined in three human urothelial carcinoma (UC) cells (parental, NTUB1; cisplatin-resistant, N/P(14); arsenic-resistant, N/As(0.5)). MTT assay median-effect analysis revealed that LZP-F3 could profoundly reverse the chemosensitivity N/P(14) N/As(0.5) to cisplatin arsenic, respectively, a dose-dependent manner, which involved activation p38 down-regulation Akt XPA. A...
ABSTRACT Transcription factor CCAAT/enhancer‐binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance. However, the underlying molecular mechanisms of CDDP‐regulated its relevant CDDP responses remain elusive. MicroRNAs (miRNAs) are small non‐coding RNAs negatively regulate gene a sequence‐specific manner. Abnormal miRNAs is associated with In current...
Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR associated with high grade tumors a worse prognosis. Recent suggest anticancer therapies targeting the pathway promising results in clinical trials RCC patients. Therefore, characterization level localization expression important for target-dependent therapy. In this study, we...
Maintenance of genomic integrity is an essential cellular function. We previously reported that the transcription factor and tumor suppressor CCAAT/enhancer binding protein δ (C/EBPδ, CEBPD; also known as “NFIL-6β”) promotes stability. However, molecular mechanism was not known. Here, we show C/EBPδ a DNA damage-induced gene, which supports survival mouse bone marrow cells, embryo fibroblasts (MEF), human fibroblasts, breast cells in response to cross-linking agent mitomycin C (MMC). Using...
ADP-ribosylation factor 6 (ARF6) is a well-studied protein that involved in multiple biological functions including cell migration and invasion. The mechanism by which ARF6 regulates the invasion of upper tract urothelial carcinoma (UTUC) still unknown. MiR-145-5p tumor suppressor microRNA, downregulated several cancer types. We aimed to elucidate molecular underlying regulation miR-145-5p UTUC. expression was observed be higher UTUC tissues than paired adjacent normal tissues. A reverse...
ABSTRACT The incidence of upper tract urothelial carcinoma (UTUC) in Taiwan is high, characterized by aggressive clinical behavior and a tendency to be more invasive at diagnosis. Identifying tumorigenic genes remains an important challenge. Myc binding protein 2 (MYCBP2) regulates the cAMP, p38MAPK, TSC/mTOR, autophagy signaling pathways mammalian cells. MYCBP2 dysfunction has been associated with poor prognosis leukemia, melanoma, colon, prostate cancer. Its role UTUC needs clarified. We...
A known triterpenoid, β-amyrin (1), and a new phloroglucinol, cohulupone (2) garcinielliptone P (3), were isolated from the pericarp heartwood seed of Garcinia subelliptica, respectively. xanthonolignoid, hyperielliptone HF (4), was Hypericum geminiflorum. The compounds established by analysis their spectroscopic data. Compounds 1−3 showed an inhibitory effect on xanthine oxidase (XO). Treatment NTUB1, human bladder cancer cell, with 1 or cotreated cisplatin for 24 h resulted in decreased...
Epidemiologic and clinical research indicates that chronic inflammation increases the risk of certain cancers, possibly through chromosomal instability. However, mechanism inflammation-dependent instability associated with tumorigenesis is not well characterized. The transcription factor CCAAT/enhancer-binding protein δ (C/EBPδ, CEBPD) induced by tumor necrosis α (TNFα) expressed in chronically inflamed tissue. In this study, we show TNFα promotes aneuploidy. Loss CEBPD attenuated...
Bioguided fractionation of the CHCl3 extracts obtained from Celastrus kusanoi stems led to isolation two new terpenoids, 3β-hydroxy-11,14-oxo-abieta-8,12-diene (1) and 3β-trans-(3,4-dihydroxycinnamoyloxy)-11α-methoxy-12-ursene (2), four known compounds characterized by spectroscopic methods. Compounds 1 2 triterpenoid erythrodiol (3) exhibited cytotoxic activity against bladder cancer cells (NTUB1) with IC50 values 58.2 ± 2.3, 160.1 60.9, 18.3 0.5 μM, respectively. Exposure NTUB1 3 (5 10 μM)...