Jinping Gao
A5011207006- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Endometrial and Cervical Cancer Treatments
- Skin and Cellular Biology Research
- Genetic and rare skin diseases.
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Financial Reporting and XBRL
- Hair Growth and Disorders
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- melanin and skin pigmentation
- Crystallization and Solubility Studies
- Contact Dermatitis and Allergies
- Diabetes and associated disorders
- Ferroptosis and cancer prognosis
- Urticaria and Related Conditions
First Affiliated Hospital of Anhui Medical University
2010-2024
Anhui Medical University
2015-2024
General Hospital of Shenyang Military Region
2022-2023
Tianjin Medical University General Hospital
2017-2020
Shandong Provincial Hospital
2019-2020
Shandong First Medical University
2020
Shandong University
2019
Beijing University of Posts and Telecommunications
2008-2018
Institute of Forensic Science
2017
Zhangjiagang First People's Hospital
2015
Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-syndromic orofacial clefts (NSOFC), which are common craniofacial birth defects in humans. Here we conduct a GWAS NSCLP multiple independent replications, totalling 7,404 NSOFC cases and 16,059 controls from several ethnicities, to identify new risk loci, explore genetic heterogeneity between sub-phenotypes NSOFC. We 41 SNPs within 26 loci that achieve genome-wide significance, 14 novel (RAD54B, TMEM19,...
Abstract Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and contributions of coding variants not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting 42,760 individuals. We discover 16 SNPs within 15 new genes/loci psoriasis, including C1orf141 , ZNF683 TMC6 AIM2 IL1RL1 CASR SON ZFYVE16 MTHFR CCDC129 ZNF143 AP5B1 SYNE2...
Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published autoimmunity is that different diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional shared by SLE in Chinese Han population.In total, 20 single nucleotide polymorphisms (SNPs) 17 previously reported 34 SNPs 24 were investigated our initial GWAS dataset....
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of considerable genetic predisposition. Genome-wide association studies have identified tens common variants for SLE. However, the majority them reside in non-coding sequences. The contributions coding not yet been systematically evaluated.We performed large-scale exome-wide study 5004 SLE cases and 8179 healthy controls Han Chinese population using custom exome array, then genotyped 32 with suggestive evidence an independent...
The skin microbiota is an inseparable component of the barrier structure, which participates in stabilization or impairment function as well development many diseases. To characterize normal and its association with sites, age sex, we recruited 50 volunteers divided into children, adolescents, young adults, middle-aged adults elderly. sites consisted cheeks, volar forearms (representing dry environments) upper back sebaceous environments). A total 9 574 365 high-quality sequences V3 to V4...
Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS) in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 3q22.3, rs8032158 15p21.3) for keloid. In order to examine whether these are associated keloid the Chinese Han population, twelve previously reported SNPs were selected replication 714 cases 2,944 controls by using Sequenom MassArray system. We found three two regions...
<h3>Background</h3> Disseminated superficial actinic porokeratosis (DSAP) is a rare autosomal dominant genodermatosis characterised by annular lesions that has an atrophic centre and prominent peripheral ridge distributed on sun exposed area. It exhibits high heterogeneity, five linkage loci have been reported. The mevalonate kinase (<i>MVK</i>) gene located 12q24 confirmed as one of the disease-causing genes. But, pathogenesis large part DSAP remains unclear so far. <h3>Methods</h3>...
Despite evidence that estrogens and insulin are related to type 1 endometrial carcinoma (EC), their synergistic role has not been analyzed. Here, we investigated how cooperate with promote EC progression. We examined the clinical significance of serum estrogen levels using patients control subjects. Univariate multivariate logistic regression analyses for total, premenopausal, postmenopausal subjects were performed. Type risk was evaluated respect estrone, estradiol, based on odds ratios...
<h3>Background</h3> <i>ZMIZ1</i> has been shown to be associated with multiple autoimmune diseases and play a role in the development of melanocyte. The association vitiligo was also suggested, but evidence did not reach genome-wide significance confirmed by independent studies. <h3>Methods</h3> A fine mapping analysis locus carried out dataset 1117 patients 3437 controls through deep imputation. Ten suggestive SNPs were then analysed an validation cohort 7458 cases 7542 controls. within...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by abnormal activation of T cells and caused an imbalance in the production clearance apoptotic cells. We previously showed that transcription regulator Bach2 regulated B‐cell SLE. Here, we investigated whether was also involved Th9 cell differentiation found proportion enhanced peripheral blood mononuclear (PBMC) SLE patients. The PBMC CD4 + patients exhibited decrease expression increase IL‐9 expression....
Immunoglobulin-A vasculitis (IgAV) is an immune-related systemic with unclear etiology. Genetic predisposition now considered to be closely associated the development of disease, and it essential reveal relationship between them. To explore role heredity in we performed a genome-wide association study (GWAS) 496 IgAV cases 7165 controls using Illumina Infinium Global Screening Array chip.In first stage analysis, significant correlation major histocompatibility complex (MHC) was observed....