A5100402562- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Medicinal Plant Pharmacodynamics Research
- Glycosylation and Glycoproteins Research
- Systemic Lupus Erythematosus Research
- Advanced biosensing and bioanalysis techniques
- Influenza Virus Research Studies
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Pharmacogenetics and Drug Metabolism
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Analytical Chemistry and Chromatography
Shenzhen Institutes of Advanced Technology
2023-2025
Chinese Academy of Sciences
2023-2025
Shanghai Jiao Tong University
2025
Weifang Medical University
2025
Air Force Medical University
2025
Xijing Hospital
2025
Army Medical University
2015-2024
Soochow University
2024
Southwest Hospital
2015-2024
Gannan Medical University
2024
Although Western diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), corresponding host cellular mechanisms remain poorly defined. Here we report that TSC1/mTOR pathway in gut epithelium represents a metabolic innate immune checkpoint for intestinal dysfunction inflammation. mTOR hyperactivation triggered by or Tsc1 ablation led to necroptosis, barrier disruption, predisposition dextran sulfate sodium-induced colitis...
Stroke is the most common cause of disability globally. Neural stem cell (NSC) therapy, which can replace lost and damaged neurons, has been proposed as a potential treatment for stroke. The therapeutic efficacy NSC therapy hindered by fact that only small number NSCs undergo neuronal differentiation. Neuron-specific miR-124, promotes differentiation into mature be combined with to cure ischemic However, instability poor internalization miR-124 seriously hamper its broad clinical...
Strategies to overcome toxicity and drug resistance caused by chemotherapeutic drugs for targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous studies revealed that high oxidored-nitro domain-containing protein 1(NOR1) expression in HCC was associated with cisplatin (DDP) resistance. Herein, a novel dual-targeting nanocarrier system AR-NADR generated the treatment of DDP HCC. The core is metal-organic frameworks (MOF) modified nuclear location sequence (NLS),...
Induction of NF-κB–dependent gene expression plays an important role in a number biological processes including inflammation and ischemia-reperfusion injury. However, few attempts aimed at selective regulation this transcription factor have been successful. We report here that naturally occurring antibacterial peptide PR39 reversibly binds to the α7 subunit 26S proteasome blocks degradation NF-κB inhibitor IκBα by ubiquitin-proteasome pathway without affecting overall activity....
Abstract Icaritin, a hydrolytic product of icariin isolated from traditional Chinese herbal medicine genus Epimedium , has many pharmacological and biological activities. Here, we show that icaritin can effectively decrease tumor burden murine B16F10 melanoma MC38 colorectal tumors in T‐cell dependent manner. The treatment effects are associated with increased CD8 infiltration effector memory frequency. In vivo depletion T cell using an anti‐CD8 monoclonal antibody abolished the antitumor...
Abstract In addition to inhibiting persistent inflammation, phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is known as an important therapeutic target for alleviating rheumatoid arthritis (RA) symptoms. Modulation of PTEN gene expression in synovial tissue using messenger RNA (mRNA) a promising approach combat RA. However, mRNA therapeutics are often hampered by unsatisfactory stability inefficient localization tissue. this study, genetically engineered biomimetic...
Abstract Icaritin, a small molecule currently being investigated in phase III clinical trials China (NCT03236636 and NCT03236649) for treatment of advanced hepatocellular carcinoma (HCC), is prenylflavonoid derivative obtained from the Epimedium genus . Previously, it was found that Icaritin decreased expression PD‐L1, but its direct molecular targets underlying mechanisms have not been identified. In this study, we report identification IKK‐α as protein target by biotin‐based affinity...
Accurate genotyping is important for genetic testing. Sanger sequencing-based typing the gold standard genotyping, but it has been underused, due to its high cost and low throughput. In contrast, short-read sequencing provides inexpensive high-throughput sequencing, holding great promise reaching goal of cost-effective genotyping. However, length paucity appropriate methods, pose a major challenge. Here, we present RCHSBT—reliable, sequence based pipeline—which takes short reads as input,...
Virus-induced central nervous system (CNS) diseases represent a significant burden to animal health worldwide. The difficulty in treating these is mainly attributable the elaborate barrier system, which limits transport of drugs infected sites. Therefore, it necessary develop smart delivery technologies for treatment diseases. In study, viral necrosis disease was studied as model evaluate feasibility multiwalled carbon nanotubes (MWCNTs) conjugated with virus-specific nanobody and antiviral...
FoxP3+ regulatory T (Treg) cells have diverse functions in the suppression of antitumor immunity. We show that FoxP3hiCD45RA-CD4+ Treg [activated (aTreg) cells] are predominant cell population among tumor-infiltrating cells, and high aTreg cell-infiltrating content is associated with reduced survival patients head neck squamous carcinoma (HNSCC). In vitro studies demonstrated can suppress tumor-associated antigen (TAA) effector immune responses HNSCC. Moreover, C-C chemokine receptor 4...
Despite the extensive development of peptide-based tumor antigen vaccines, field still faces up enormous challenges from lacking clinical efficacy. Here, we report design and a therapeutic nanovaccine for cancer immunotherapy by using gold nanoparticle (AuNPs)-conjugated peptides incorporation with supramolecular hydrogel, via featured host-guest interactions to carry deliver select in conjunction unmethylated cytosine-guanine oligodeoxynucleotide (CpG). The injectable shows significant...
Abstract Background Multiple molecular subtypes with distinct clinical outcomes in pancreatic adenocarcinoma (PAAD) have been identified recent years. Cuproptosis is a new form of cell death that likely involved tumor progression. However, the cuproptosis-related as well its mediated microenvironment (TME) infiltration characteristics largely remain unclear. Methods Expression profiles 10 genes (CRGs) and their association patient survival, TME, cancer stemness drug resistance were studied...
Abstract Donor major histocompatibility complex class I (MHC I) molecules are the main targets of host immune response after organ allotransplantation. Whether and how MHC I-deficiency pig donor tissues affects rejection xenotransplantation has not been assessed. Beta2-microglobulin (B2M) is indispensable for assembly receptors therefore provides an effective target to disrupt cell surface expression. Here, we report one-step generation mutant pigs with targeted disruptions in B2m by...
Disulfidptosis, a novel form of disulfide stress-induced cell death involved in tumor progression, hasn't be well defined the function progression. And clinical impacts disulfidptosis-related genes (DRGs) pancreatic adenocarcinoma (PAAD) remain largely unclear. In this study, we identified two distinct disulfidptosis subtypes and found that multilayer DRG alterations were associated with prognosis TME infiltration characteristics. A three-gene prognostic signature was constructed to predict...