A5027902249- Psoriasis: Treatment and Pathogenesis
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Genetic and rare skin diseases.
- Immune Cell Function and Interaction
- melanin and skin pigmentation
- Healthcare Systems and Challenges
- Skin and Cellular Biology Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Protein Tyrosine Phosphatases
- Atherosclerosis and Cardiovascular Diseases
- Click Chemistry and Applications
- Tumors and Oncological Cases
- Retinoids in leukemia and cellular processes
Peking University Shenzhen Hospital
2020-2025
University of Hong Kong
2020-2025
Hong Kong University of Science and Technology
2020-2025
Taizhou Second People's Hospital
2024-2025
Yangzhou University
2024-2025
University of Hong Kong - Shenzhen Hospital
2025
Hebrew SeniorLife
2019-2021
Harvard University
2019-2021
China-Japan Friendship Hospital
2018-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2020
Abstract Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and contributions of coding variants not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting 42,760 individuals. We discover 16 SNPs within 15 new genes/loci psoriasis, including C1orf141 , ZNF683 TMC6 AIM2 IL1RL1 CASR SON ZFYVE16 MTHFR CCDC129 ZNF143 AP5B1 SYNE2...
Artificial intelligence (AI) had been first coined at a famous Dartmouth College conference in 1956. AI is gradually interrelated with all disciplines, and also permeates aspects of the medical field. In early 1970s, researchers discovered applicability life sciences.[1] can play role many aspects, such as image recognition auxiliary diagnosis,[2] biotechnology,[3] drug research development,[4] etc. Currently, most widely used. Dermatology subject that relies on morphological features,...
Abstract Psoriasis is an autoinflammatory skin disease characterized by the abnormal activation of epidermal keratinocytes. The Hippo-YAP pathway evolutionarily conserved that plays important roles in organ size control and tumorigenesis. Recently, accumulating evidence demonstrated YAP1, core downstream component pathway, was up-regulated psoriasis patients, suggesting its possible role development. However, precise function mechanism pathogenesis are still not well-clarified. In present...
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting predominantly females.To discover additional genetic risk variants for SLE on the X chromosome, we performed a follow-up study of our previously published genome-wide association (GWAS) data set in this study.Methods: Twelve single nucleotide polymorphisms (SNPs) within novel or unpublished loci with P-value < 1.00 × 10 -02 were selected genotype total 2,442 cases and 2,798...
Abstract Superficial skin erosion wounds are very common in the clinic, and conventional treatments not always effective; thus, effective novel therapy is needed. Cold atmospheric plasma (CAP) has been recognised as a promising approach to wound healing. The purpose of this study show potential clinical application CAP for healing different kinds superficial wounds. Seven patients with (two pyoderma gangrenosum, two trauma would, one patient giant genital wart, diabetic foot, chronic eczema)...
Abstract Psoriasis is an auto-inflammatory skin disease characterized by abnormal activation of epidermal keratinocytes, aberrant neovascularization, and dysregulation immune cells. MicroRNAs are small non-coding RNAs that mainly function in the post-transcriptional regulation gene expression. Recently, accumulating evidence has demonstrated expression microRNAs dysregulated psoriasis patients play key roles pathogenesis. Downregulation miR-193b-3p been identified to be associated with...
<h3>Background</h3> Disseminated superficial actinic porokeratosis (DSAP) is a rare autosomal dominant genodermatosis characterised by annular lesions that has an atrophic centre and prominent peripheral ridge distributed on sun exposed area. It exhibits high heterogeneity, five linkage loci have been reported. The mevalonate kinase (<i>MVK</i>) gene located 12q24 confirmed as one of the disease-causing genes. But, pathogenesis large part DSAP remains unclear so far. <h3>Methods</h3>...
Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and altered keratinocyte differentiation inflammation caused the interplay of genetic environmental factors. Previous studies have revealed that DNA methylation (DNAm) makers are closely associated with psoriasis, strong evidences shown DNAm can be controlled factors, which attracted us to evaluate relationship among DNAm, makers, status.We utilized genome-wide data psoriatic (PP, N = 114)...
Psoriasis is a complex disease influenced by both genetic and environmental factors with abnormal gene expression in lesional skin. However, no studies are available on genome‐scale of psoriatic lesions the Chinese population. In addition, systematic biological pathways, pathogenicity interaction networks psoriasis‐related genes profiles require further investigation. To explore associated pathways psoriasis functional analysis to identify key analysis. We performed RNA sequencing 60 skin...
Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise underlying 110 SLE that were in latest East Asian GWAS meta-analysis.
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) well non-gastrointestinal lung, breast, melanoma cancers). Due to the innate anatomical position of liver, apoptosis T cells in unique metabolic regulation hepatocytes other potential mechanisms, tends form an immunosuppressive microenvironment subsequently pre-metastatic niche (PMN), which can promote metastasis colonization by various tumor cells(TCs). As result,...
We confirmed that the filaggrin gene mutation c.3321delA is associated with atopic dermatitis in our previous genome wide association study of Chinese Han population. most common patients but not present European populations.To investigate genetic model for and to determine correlation between clinical phenotypes population.The was sequenced 1,080 908 controls from The χ2 test, ANOVA,nonparametric tests logistic regression were used relationship genotype population.Analyses revealed additive...
With numbers of common variants identified mainly through genome-wide association studies (GWASs), there is great interest in incorporating the findings into screening individuals at high risk psoriasis. The purpose this study to establish genetic prediction models and evaluate its discriminatory ability psoriasis Han Chinese population. We built weighted polygenic score (PRS) using 14 susceptibility 8,819 samples. found among top quartile PRS was significantly larger than those lowest (OR =...
Background: Artificial intelligence (AI) has become a powerful tool and is attracting more attention in the field of medicine. There are number AI studies focusing on skin diseases, there many products that have been applied dermatology. However, attitudes dermatologists, specifically those from China, towards AI, not clear as few, if any focused this issue. Methods: A web-based questionnaire was designed by experts Chinese Skin Image Database (CSID) published UMER Doctor platform (an online...
Background It has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B‐del) is associated with susceptibility to psoriasis European populations. However, relationship remains unclear northern Chinese population. Objectives The aim of present study was clarify this association Methods In total, 970 patients and 1064 healthy controls were recruited polymerase chain reaction assay used determine frequency deletion. effect on assessed using SPSS software...
The aim of this study was to explore the role p38 mitogen-activated protein kinase (p38MAPK)/p53 signaling pathway in injury intestinal mucosal barrier during severe acute pancreatitis (SAP).Both sham operation and SAP groups had 3 subgroups analyzed 3, 6, or 12 hours after induction. concentrations amylase, endotoxin, diamine oxidase, tumor necrosis factor α, phospho-p38MAPK, p53, caspase-3 messenger RNA levels zonula occludens protein-1 occludin intestine were measured. Immunohistochemical...