A5014659807- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- Chromatin Remodeling and Cancer
- Adenosine and Purinergic Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Testicular diseases and treatments
- Rheumatoid Arthritis Research and Therapies
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
Soochow University
2020-2024
Jiangsu University
2024
Nanjing University of Aeronautics and Astronautics
2024
Mayo Clinic in Florida
2024
Affiliated Hospital of Jiangsu University
2024
Pancreatic Cancer Action Network
2024
First Affiliated Hospital of Soochow University
2024
The First People's Hospital of Changzhou
2021-2023
University of Glasgow
2020
National Health and Family Planning Commission
2018
Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Th1 Th17 cells. Studies have confirmed that natural CD4+Foxp3+ Tregs were unstable dysfunctional in the presence of pro-inflammatory cytokines. In current study, human CD39hi CD39low sorted from vitro after 7 days expansion. The functions both Treg subsets investigated under inflammatory conditions vivo. IL-1β IL-6, cultured CD4+CD39hi maintained stable forkhead box protein 3...
Increasing evidence indicates that preoperative prognostic indices can serve as independent predictors of survival in patients with cancer. However, the applicability these hepatocellular carcinoma (HCC) is controversial. This study aims to investigate value HCC after curative hepatectomy. We retrospectively analyzed data 215 who underwent resection for HCC. Prognostic including nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) were evaluated by comparing area under curve...
Abstract Infiltration of eosinophils is associated with and contributes to liver regeneration. Chemotaxis orchestrated by the eotaxin family chemoattractants. We report here that expression eotaxin-1 (referred as hereafter), but not either eotaxin-2 or eotaxin-3, were elevated, measured quantitative PCR ELISA, in proliferating murine livers compared quiescent livers. Similarly, exposure primary hepatocytes hepatocyte growth factor (HGF) stimulated expression. Liver specific deletion...
Mitogen-activated protein kinase (MAPK) signaling plays a significant role in reactive oxygen species (ROS) production. The authors have previously shown that Brahma-related gene 1 (BRG1), chromatin remodeling protein, contributes to hepatic ROS accumulation multiple animal and cellular models of liver injury. Here it is reported DNA damage-induced transcript 4 (DDIT4) identified as direct transcriptional target for BRG1. DDIT4 overexpression overcomes BRG1 deficiency restore production...
Liver injuries induced by various stimuli share in common an acute inflammatory response, which circulating macrophages home to the liver parenchyma participate regulation of repair, regeneration, and fibrosis. In present study we investigated role hepatocyte-derived C-C motif ligand 7 (CCL7) macrophage migration during injury focusing on its transcriptional regulation. We report that CCL7 expression was up-regulated lipopolysaccharide (LPS) injection (acute injury) or...
Mounting evidence has demonstrated that circular RNAs have an important function in tumorigenesis and cancer evolvement. CircCRIM1 been shown to be a poor prognostic element multiple human malignancies. However, the clinical significance mechanism of circCRIM1 hepatocellular carcinoma (HCC) is still unclear. The present study confirmed expression level using quantitative real-time PCR. In addition, siRNA overexpression vectors were used for transfection into LM3 or Huh7 cells down-...
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) well non-gastrointestinal lung, breast, melanoma cancers). Due to the innate anatomical position of liver, apoptosis T cells in unique metabolic regulation hepatocytes other potential mechanisms, tends form an immunosuppressive microenvironment subsequently pre-metastatic niche (PMN), which can promote metastasis colonization by various tumor cells(TCs). As result,...
It has been shown that rapamycin is able to significantly increase the expression of FoxP3 and suppress activity in induced Treg (iTreg) cells vivo vitro . CD39 a newly determined marker relates cell suppression. Runx1, regulator FoxP3, controls adenosine deaminase (ADA) gene, which found recently downstream pathway trophoblast cells. Whether would influence regulate Runx1 remains be determined. The addition human CD4 + naïve presence IL-2, TGF- β promotes FoxP3. In this paper, we positively...
Circular RNAs (circRNAs), continuous loops of single-stranded RNA, regulate gene expression during the development various cancers. However, function circRNAs in hepatocellular carcinoma (HCC) is rarely discussed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine mRNA levels circ_0011385, miR-361-3p, and STC2 96 pairs HCC tissues (tumor adjacent normal tissues), cell lines, L02 (human liver line) cells. The relationships between circ_0011385 clinical features...
Programmed cell death-1 (PD-1) immune checkpoint inhibitors are not effective in treating all patients with hepatocellular carcinoma (HCC), and regulatory T cells (Tregs) may determine the resistance to anti-PD-1 therapy. Patients were divided into two groups based on clinical efficacy of Flow cytometry was used phenotype CD4+, CD8+, Tregs peripheral blood mononuclear (PBMCs). CD4+CD45RA+T sorted analyze Treg differentiation function. No significant differences found between resistant...
Rheumatoid arthritis (RA) is one of the most common chronic immune joint diseases, mainly involving blood vessels and small joints. The complex pathogenesis RA greatly increases difficulty treatment. At present, hormone immunosuppressive therapy are not effective, while low-dose interleukin-2 (IL-2) recently has been found to possess some advantages for immunotherapy. However, its related signal pathway remains be elucidated.We fabricated model in mice, then IL-2 was injected at a fixed time...
Transfer of splenocytes isolated from B6 mice into normal B6D2F1 induces acute graft-versus-host disease (aGVHD), resulting in the expansion donor cytotoxic T lymphocytes that eliminate recipient B cells. The cytokine IL-22, secreted by Th1 cells, Th17 and innate immune is structurally related to IL-10. To investigate association between IL-22 aGVHD, an anti-mouse antibody (IL-22Ab) was used ablate activity a mouse aGVHD model. Administration IL-22Ab significantly reduced progression...
In emergency surgery for acute obstruction of the common bile duct (CBD), primary closure (PC) CBD after laparoscopic exploration (LCBDE) remains challenging.To explore safety and effectiveness this surgical method LCBDE in patients with choledocholithiasis discuss feasibility PC CBD.This retrospective study on efficacy involved 232 treated at The Third Affiliated Hospital Soochow University between January 2015 December 2019. These underwent LC + were categorized into T-tube drainage (TD)...
// Zengyao Li 1, * , Jian Gu Qin Zhu Jing Liu 2 Hao Lu 1 Yunjie and Xuehao Wang Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, 210029, China Department of Radiotherapy, These authors have contributed equally to this work Correspondence to: Wang, email: wangxh@njmu.edu.cn Keywords: obesity, aGVHD, transplantation Received: April 21, 2017 Accepted: June 04, Published: August 24, ABSTRACT Acute graft-versus-host disease (aGVHD) remains one the most severe...
Objective: This retrospective study aimed to present our surgical experience in patients with primary retroperitoneal tumors (PRTs) who underwent laparoscopic surgery and compare the results those of an open operation. Materials Methods: We analyzed medical data tumor resection through or operation between February 2014 November 2019. Results: In total, 77 were enrolled. 37 40 surgery. The size group (10.2 ± 5.4 cm) was more significant than that (6.5 3.1 (P < .001). No difference observed...