A5039932983- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and disorders
- Monoclonal and Polyclonal Antibodies Research
- FOXO transcription factor regulation
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Renal and related cancers
- Galectins and Cancer Biology
- Mechanisms of cancer metastasis
- Nanoplatforms for cancer theranostics
- Signaling Pathways in Disease
- Cancer, Lipids, and Metabolism
University of Colorado Anschutz Medical Campus
2015-2025
Nanjing Medical University
2020-2025
Nanjing University of Posts and Telecommunications
2024
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Xiamen University
2023-2024
Xiamen University
2024
Real Jardín Botánico
2023
Universidad de Alcalá
2023
University of Pretoria
2023
Westerdijk Fungal Biodiversity Institute
2023
Abstract B7-H4 is a recently identified B7 family member that negatively regulates T cell immunity by the inhibition of proliferation, cytokine production, and cycle progression. In this study, we report genomic DNA human mapped on chromosome 1 comprised six exons five introns spanning 66 kb, which exon 6 used for alternative splicing to generate two different transcripts. Similar structure also found in mouse 3. A pseudogene 20p11.1 with single stop codons coding region....
Five to 10% of patients with differentiated thyroid cancers (DTC) develop invasive and/or distant metastatic disease that is marginally improved standard therapies. Prognosis poor for anaplastic cancer, a median survival 3–5 months. We suggest paradigm shift necessary in the treatment advanced cases. hypothesized T-cell response generated cancer and may be viable therapeutic target. Primary DTCs were analyzed by quantitative RT-PCR (n = 92) expression CD3, CD8, forkhead box (Fox)-P3,...
B7-H3 is a cell surface molecule in the immunoglobulin superfamily that frequently upregulated response to autoantigens and pathogens during host T immune responses. However, B7-H3's role differential regulation of subsets remains largely unknown. Therefore, we constructed new deficient mouse strain (B7-H3 KO) evaluated functions Th1, Th2, Th17 experimental autoimmune encephalomyelitis (EAE), asthma, collagen-induced arthritis (CIA); these models were used predict human responses multiple...
The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates hypoxic tumor microenvironment that actively limits immune cell infiltration. molecular basis underpinning this dysfunction is not fully understood. Using genome-scale receptor array technology, we showed here insulin-like growth factor binding protein 7 (IGFBP7) interacts with its CD93, subsequently demonstrated interaction contributes abnormal vasculature....
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg has been challenging. Here, using single-cell RNA sequencing immune from renal clear carcinoma (ccRCC) patients, we identify two distinct transcriptional fates TI cells, Fate-1 Fate-2. The signature is associated with poorer prognosis ccRCC several other solid cancers. CD177, surface protein normally expressed on...
T cell receptor (TCR) and costimulatory (CD28) signals cooperate in activating cells, although understanding of how these pathways are themselves regulated is incomplete. We found that Homer2 Homer3, members the Homer family cytoplasmic scaffolding proteins, negative regulators activation. This achieved through binding nuclear factor activated cells (NFAT) by competing with calcineurin. Homer-NFAT was also antagonized active serine-threonine kinase AKT, thereby enhancing TCR signaling via...
Introduction Despite accumulated evidence in T-cell exhaustion acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade AML failed to achieve satisfying efficacy. Characteristics of remained be explored. Methods Phenotypic analysis bone marrow (BM) using flow cytometry combining senescent and markers was performed de novo patients healthy donors well with complete remission (CR). Functional subsets also cytometry....
The SALM5-HVEM interaction limits inflammation and contributes to immune privilege in the CNS.
Nanoparticle (NP)-based cancer immunotherapy has been extensively explored. However, the efficacy of existing strategies is often limited by lack effective tumor-specific antigens or inability to present costimulatory signal both. Here, we report a novel approach overcoming these limitations through surface coating with dendritic-tumor fusion cell membranes, which whole repertories tumor-associated in presence molecules. Because antigen-presenting and molecules are displayed on their...
Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires more detailed characterization of the cellular populations involved controlling metastatic burden.PDAC patient tissue samples were subjected RNA sequencing analysis identify changes immune infiltration following radiotherapy. Genetically engineered mouse strains combination with orthotopic tumor models PDAC used...
For many solid tumors, immune checkpoint blockade therapy has become first line treatment, yet a large proportion of patients with immunologically cold tumors do not benefit due to the paucity tumor infiltrating lymphocytes. Here we show that orphan G Protein-Coupled Receptor 182 (GPR182) contributes immunotherapy resistance in cancer via scavenging chemokines are important for lymphocyte recruitment tumors. GPR182 is primarily upregulated melanoma-associated lymphatic endothelial cells...