A5067026862- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Sphingolipid Metabolism and Signaling
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Vitamin C and Antioxidants Research
- Autophagy in Disease and Therapy
- Vitamin K Research Studies
- Cancer Immunotherapy and Biomarkers
- Listeria monocytogenes in Food Safety
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
University of Colorado Anschutz Medical Campus
2021-2025
University of Colorado Denver
2022-2023
University of Wisconsin–Madison
2017
Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors limited. These challenges may be addressed through rational manipulations to control CAR cell function. Here we examine the impact of cognate experience on subsequent CD8+ activity. Prior encounter resulted superior effector function leukemia expressing low target density at expense reduced proliferative capacity susceptibility dysfunction...
Abstract Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and systemically across different cancer types. Yet, the exact mechanism(s) of how LPA affects CD8 T cell immunosurveillance during tumor progression remain unknown. We show receptor (LPAR) signaling by cells promotes tolerogenic states via metabolic reprogramming potentiating exhaustive-like differentiation to modulate anti-tumor immunity. found levels predict response immunotherapy Lpar5...
ABSTRACT Through unknown mechanisms, the host cytosol restricts bacterial colonization; therefore, only professional cytosolic pathogens are adapted to colonize this environment. Listeria monocytogenes is a Gram-positive intracellular pathogen that highly of both phagocytic and nonphagocytic cells. To identify L. determinants survival, we designed executed novel screen isolate mutants with survival defects. Multiple identified in were defective for synthesis menaquinone (MK), an essential...
Abstract Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and systemically across different cancer types. Yet, the exact mechanism(s) of how LPA affects CD8 T cell immunosurveillance during tumor progression remain unknown. We show receptor (LPAR) signaling by cells promotes tolerogenic states via metabolic reprogramming potentiating exhaustive differentiation to modulate anti-tumor immunity. found levels predict response immunotherapy Lpar5 drives...
Abstract Chimeric antigen receptor (CAR) T cells are highly effective in treating hematologic cancers, but patients can relapse due to downregulation of the CAR-targeted antigen, leading hypothesis that CAR require high density target be effective. Non-engineered CD8+ memory generate more rapid and robust effector cell responses upon secondary infection, relative their naïve counterparts, display higher sensitivity. Our objective was characterize role prior experience (AgEx) dictating...
Chimeric antigen receptor T cells are an effective therapy for B-lineage malignancies. However, many patients relapse and this therapeutic has yet to show strong efficacy in other hematologic or solid tumors. One opportunity improvement lies the ability generate with desirable functional characteristics. Here, we dissect biology of CD8+ CAR (CAR8) by controlling whether cell encountered cognate TCR prior generation. We find that experience influences multiple aspects
Abstract Persistent viral infections such as Human Immunodeficiency Virus (HIV), Hepatitis B and C Viruses (HBV & HCV), Epstein Barr (EBV) result in high mortality rates, tremendous healthcare costs, limit global life expectancies. Paramount to establishing maintaining chronic infections, viruses must evade or suppress T cell-mediated immunity, often through promoting the generation of dysfunctional “exhausted” CD8 cells. Although there are considerable research efforts investigating...