A5028801725- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- RNA Interference and Gene Delivery
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Hearing, Cochlea, Tinnitus, Genetics
- Salivary Gland Tumors Diagnosis and Treatment
- Meningioma and schwannoma management
- Tracheal and airway disorders
- Ear and Head Tumors
- Voice and Speech Disorders
- vaccines and immunoinformatics approaches
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Dysphagia Assessment and Management
- Brain Metastases and Treatment
University of Tennessee Health Science Center
2019-2024
UC San Diego Health System
2024
University of Maryland, Baltimore
2011-2023
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2008-2015
University of Pennsylvania
2014
Oncovir (United States)
2014
University of Maryland Medical Center
2005-2013
University of Baltimore
2011-2013
University of Maryland, College Park
2010-2011
Cleveland Clinic Lerner College of Medicine
2011
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing potential costimulatory signal source for regulation T cell activation. In contrast, aberrant expression B7-H1 by tumor cells has been implicated impairment function and survival, resulting defective host antitumoral immunity. The relationship between tumor-associated clinical cancer progression unknown. Herein, we report both renal carcinoma (RCC) tumors kidney...
You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 8:00 am - 12:00 pm1 Apr 2005618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator Tumor Aggressiveness and Potential Therapeutic Target R. Houston Thompson, Michael D. Gillett, John C. Cheville, Christine M. Lohse, Haidong Dong, W. Scott Webster, Kent G. Krejci, Lobo, Shomik Sengupta, Lieping Chen, Horst Zincke, L. Blute, E. Strome, Bradley Leibovich, Eugene Kwon ThompsonR. Thompson More articles by this...
Abstract The burden of squamous cell carcinoma the head and neck (SCCHN) is greater for blacks than whites, especially in oropharyngeal cases. We previously showed retrospectively that disease-free survival was significantly white black SCCHN patients treated with chemoradiation, greatest difference occurring subgroup. Oropharyngeal cancer increasing incidence its association human papillomavirus (HPV) infection; HPV-positive have better outcomes (versus HPV-negative). These collective data...
Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed cancer patients, remains a major challenge immunotherapy. We reported previously that established mice receiving an agonistic mAb to T cell costimulatory molecule 4-1BB (CD137) regress due enhanced tumor antigen–specific cytotoxic lymphocyte responses. In this study, we demonstrate several tumors, including C3 tumor, TC-1 lung carcinoma, and B16-F10...
Abstract B7-H4 is a recently identified B7 family member that negatively regulates T cell immunity by the inhibition of proliferation, cytokine production, and cycle progression. In this study, we report genomic DNA human mapped on chromosome 1 comprised six exons five introns spanning 66 kb, which exon 6 used for alternative splicing to generate two different transcripts. Similar structure also found in mouse 3. A pseudogene 20p11.1 with single stop codons coding region....
Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed cancer patients, remains a major challenge immunotherapy. We reported previously that established mice receiving an agonistic mAb to T cell costimulatory molecule 4-1BB (CD137) regress due enhanced tumor antigen–specific cytotoxic lymphocyte responses. In this study, we demonstrate several tumors, including C3 tumor, TC-1 lung carcinoma, and B16-F10...
Recurrent solid malignancies are often refractory to standard therapies. Although adoptive T cell transfer may benefit select individuals, the majority of patients succumb their disease. To address this important clinical dilemma, we developed a mouse melanoma model in which initial regression advanced disease was followed by tumor recurrence. During recurrence, Foxp3(+) tumor-specific CD4(+) cells became PD-1(+) and represented >60% host. Concomitantly, effector showed traits chronic...
A pathogenic hallmark of rheumatoid arthritis (RA) is persistent activation self-reactive CD4(+) T cells. The cause this aberrant activity remains elusive. We report here detection autoantibodies against B7-H1, a recently described member the B7 family, in 29% patients with RA versus 4% healthy donors. High-level expression cell surface B7-H1 are found on activated human CD4(+), CD8(+), and CD45RO(+) Immobilized to capable costimulating proliferation cells vitro, presence these correlates...
The expression of CD56, a natural killer cell-associated molecule, on alphabeta T lymphocytes correlates with their increased antitumor effector function. CD56 is also expressed subset gammadelta cells. However, functions CD56(+) cells are poorly characterized.To investigate the potential role in tumor killing, we used isopentenyl pyrophosphate and interleukin-2-expanded from peripheral blood mononuclear healthy donors.Thirty to 70% expanded express surface. Interestingly, although both...
Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate current stem cell gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development have been described, little known about postnatal maturating HCs. Here we apply type-specific functional genomic analysis to transcriptomes auditory vestibular sensory epithelia from early mice. We...
Myeloma-directed cellular immune responses after autologous stem cell transplantation (ASCT) may reduce relapse rates. We studied whether coinjecting the TLR-3 agonist and vaccine adjuvant Poly-ICLC with a MAGE-A3 peptide was safe would elicit high frequency of vaccine-directed when combined vaccine-primed costimulated T cells.In phase II clinical trial (NCT01245673), we evaluated safety activity ex vivo expanded cells primed in using multipeptide (compound GL-0817) (Hiltonol), granulocyte...
Abstract NK cells possess both effector and regulatory activities that may be important during the antitumor immune response. In fact, generation of immunity by administration an agonistic mAb against CD137 is cell-dependent. this study, we report could induced IL-2 IL-15 to express ligation CD137-stimulated cell proliferation IFN-γ secretion, but not their cytolytic activity. Importantly, promoted expansion activated T in vitro, demonstrating immunoregulatory or “helper” activity for...
Abstract Background We evaluated toxicity and long‐term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors. Methods Twenty‐five consecutive (age, 30–88 years; 17 women, 8 men) who underwent the Leksell Gamma Knife (dose, 12–18 Gy) were prospectively followed. MRI clinical examinations performed at 6 months 1, 2, 3 years, then every 2 years. Results None tumors increased size, stable, decreased (median imaging follow‐up, 35 months; range,...
Abstract Senescent and suppressor T cells are reported to be increased in select patients with cancer poor prognostic indicators. Based on the association of these outcomes, we hypothesized that tumors induce senescence cells, which negatively effects antitumor immunity. In this report, show human from healthy donors incubated tumor for only 6 h at a low T-cell ratio undergo senescence-like phenotype, characterized by loss CD27 CD28 expression telomere shortening. Tumor-induced is induced...