A5001572155- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Advanced Biosensing Techniques and Applications
- Immune Response and Inflammation
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- HIV Research and Treatment
- Galectins and Cancer Biology
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Axon Guidance and Neuronal Signaling
- Neuroendocrine Tumor Research Advances
- vaccines and immunoinformatics approaches
- Protein purification and stability
- Signaling Pathways in Disease
Altai State University
2014-2023
Center for Innovation
2015-2022
Arizona State University
2015-2021
State Research Center of Virology and Biotechnology VECTOR
2021
Barnaul Law Institute of the Russian Interior Ministry
2021
University of Maryland, Baltimore
2007-2013
Sepragen Corporation (United States)
2006-2013
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2008-2011
University of Baltimore
2009-2011
Cleveland Clinic Lerner College of Medicine
2011
Abstract LIGHT is a recently identified member of the TNF superfamily and its receptors, herpesvirus entry mediator lymphotoxin β receptor, are found in T cells stromal cells. In this study, we demonstrate that selectively expressed on immature dendritic (DCs) generated from human PBMCs. contrast, not detectable DCs either freshly isolated PBMCs or rendered mature vitro by LPS treatment. Blockade soluble receptor-Ig HVEM-Ig, inhibits induction DC-mediated primary allogeneic cell response....
Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed cancer patients, remains a major challenge immunotherapy. We reported previously that established mice receiving an agonistic mAb to T cell costimulatory molecule 4-1BB (CD137) regress due enhanced tumor antigen–specific cytotoxic lymphocyte responses. In this study, we demonstrate several tumors, including C3 tumor, TC-1 lung carcinoma, and B16-F10...
Abstract Interaction between dendritic cells (DCs) and T is a prerequisite for the initiation of cell response. The molecular nature this interaction remains to be fully characterized. We report in work that freshly isolated mouse splenic DCs bone marrow-derived express CD137 on surface soluble form. Triggering increased secretion IL-6 IL-12 from DCs. More importantly, infusion an agonistic mAb into naive mice enhanced ability stimulate proliferation response both alloantigens nominal Ag...
Treatment of advanced, poorly immunogenic tumors in animal models, considered the closest simulation available thus far for conditions observed cancer patients, remains a major challenge immunotherapy. We reported previously that established mice receiving an agonistic mAb to T cell costimulatory molecule 4-1BB (CD137) regress due enhanced tumor antigen–specific cytotoxic lymphocyte responses. In this study, we demonstrate several tumors, including C3 tumor, TC-1 lung carcinoma, and B16-F10...
Abstract B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The vivo role of the stimulation tumor immunity unclear. We report here that expression by transfection mouse P815 line enhances its immunogenicity, leading to regression tumors and amplification tumor-specific CD8+ CTL response syngeneic mice. Tumor cells engineered express elicit rapid clonal expansion P1A Ag-specific lymphoid organs acquire ability directly stimulate growth, division, development cytolytic...
The expression of CD56, a natural killer cell-associated molecule, on alphabeta T lymphocytes correlates with their increased antitumor effector function. CD56 is also expressed subset gammadelta cells. However, functions CD56(+) cells are poorly characterized.To investigate the potential role in tumor killing, we used isopentenyl pyrophosphate and interleukin-2-expanded from peripheral blood mononuclear healthy donors.Thirty to 70% expanded express surface. Interestingly, although both...
Abstract Senescent and suppressor T cells are reported to be increased in select patients with cancer poor prognostic indicators. Based on the association of these outcomes, we hypothesized that tumors induce senescence cells, which negatively effects antitumor immunity. In this report, show human from healthy donors incubated tumor for only 6 h at a low T-cell ratio undergo senescence-like phenotype, characterized by loss CD27 CD28 expression telomere shortening. Tumor-induced is induced...
Abstract Previous studies have demonstrated that IL-15 administration after cyclophosphamide (CY) injection of C57BL/6J mice bearing the i.m. 76-9 rhabdomyosarcoma resulted in a significant prolongation life. In present study, we investigated immune response against experimental lung metastases CY + therapy. Administration IL-15, but not alone, induced life and cures 32% established pulmonary tumor. The therapy increased levels NK1.1+/LGL-1+ cells, CD8+/CD44+ T cells PBL. vitro cytotoxic...
CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet mediating B cell function is unknown. We found that expressed vitro on anti-Ig-stimulated peripheral blood vivo tonsillar with activated phenotype. In expression enhanced by CD40 stimulation IFN-gamma inhibited IL-4, -10, -21. The human functionally relevant because engagement its ligand at time activation stimulates proliferation, enhances survival, induces secretion...
Macrophages and natural killer (NK) cells are important antitumor effectors by virtue of their ability to produce cytokines, chemokines interferons (IFNs) mediate tumor cytotoxicity. Little is known about the impact Toll-like receptor (TLR) nucleotide binding oligomerization domain (NOD)-like (NLR) pathways on NK cell functions, role TLRs NLRs in macrophage activation incompletely understood. In this study, we examined capacities expressed elicit cytokine production human THP1 macrophages,...
The interfacial properties of multiphase systems are often difficult to quantify. We describe the observation and quantification immiscible solvent entrapment on a carbonaceous electrode surface using microscopy-coupled electrogenerated chemiluminescence (ECL). As aqueous microdroplets suspended in 1,2-dichloroethane collide with glassy carbon surface, small volumes become entrapped between phase, resulting an overestimation true microdroplet/electrode contact area. To quantify contribution...
Discovery of the B7 family immune checkpoints such as CTLA-4 (CD152), PD-1 (CD279), well their ligands B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), and B7-DC (PD-L2, CD273), has opened new possibilities for cancer immunotherapy using monoclonal antibodies (mAb). The blockade inhibitory receptors (CTLA-4 PD-1) with specific mAb results in activation patients’ T lymphocytes tumor rejection. However, use clinics several limitations including side effects cost treatment. development...