A5005708663- Oral Health Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Oral and gingival health research
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- Food Allergy and Anaphylaxis Research
- Bone Tumor Diagnosis and Treatments
- Drug-Induced Adverse Reactions
- Allergic Rhinitis and Sensitization
- Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Autoimmune and Inflammatory Disorders
- Genital Health and Disease
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
Tokyo Medical and Dental University
2014-2025
Japanese Urological Association
2023-2024
Ebina General Hospital
2014
Chulalongkorn University
2011
Johns Hopkins Medicine
2009-2010
Johns Hopkins University
2006-2010
Center of Molecular Immunology (Cuba)
2003
Abstract Purpose: The negative regulatory programmed death-1/programmed death-1 ligand (PD-1/PD-L) pathway in T-cell activation has been suggested to play an important role tumor evasion from host immunity. In this study, we investigated the expression of PD-L1 and PD-L2 human esophageal cancer define their clinical significance patients' prognosis after surgery. Experimental Design: gene was evaluated 41 esophagectomy patients by real-time quantitative PCR. protein also with newly generated...
Abstract B7-H1 (PD-L1) and B7-DC (PD-L2) are the ligands for programmed death-1 (PD-1), which is a member of CD28/CTLA-4 family has been implicated in peripheral tolerance. We investigated roles murine OVA-induced allergic asthma model. was constitutively expressed on dendritic cells, macrophages, B T cells lungs naive mice, its expression could be dramatically increased after allergen challenge. In contrast, scarcely but up-regulated challenge, although up-regulation macrophages minimal....
Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that recognized as an potentially malignant disorder. However, the nature of OLP remains unclear. Methods We designed this study to examine demographic and clinical characteristics patients with evaluate associated transformation rate. A total 565 histopathological diagnosis who presented at our department between 2001 2017 were retrospectively studied. Patients had features lichenoid lesions (OLLs)...
Abstract Programmed death‐1 (PD‐1) and its ligands, B7‐H1/PD‐L1 B7‐DC/PD‐L2, are new CD28‐B7 family members that may be involved in the regulation of immune responses. We examined roles these molecules mouse hapten‐induced contact hypersensitivity (CH). Administration anti‐PD‐1 mAb at sensitization significantly enhanced prolonged ear swelling. Treatment with anti‐B7‐H1 mAb, but not anti‐B7‐DC also CH reactions. The treatment increased T cell number draining lymph nodes (DLN). B7‐H1 was...
Abstract Inducible costimulator (ICOS)-B7 homologous protein (B7h) is a new member of the CD28-B7 family costimulatory molecules that regulates T cell-dependent humoral immune responses. In this study, we examined involvement pathway in development and progression lupus NZB/W F1 mice. Expression ICOS on cells was enhanced with disease progression, whereas B7h expression B down-regulated. Administration anti-B7h mAb before onset renal significantly delayed proteinuria prolonged survival....
Oral leukoplakia can be treated using a variety of treatment procedures; however, the lesions recur in many cases irrespective procedure used. The rate recurrence was from 7.7% to 38.1%. This study aims identify important factors that lower risk oral by curative surgical resection.The clinical records 52 patients with (53 lesions) who underwent resection between 2004 and 2009 were retrospectively analyzed for recurrence, outcome, epithelial dysplasia, lesion location, margins.The following...
Abstract Objectives An understanding of the tumor immune microenvironment is required to improve treatment, especially selection checkpoint inhibitors (ICIs). In this study, we stratified immunotypes tongue squamous cell carcinoma (TSCC) based on results comprehensive profiling. Methods We enrolled 87 therapy-naïve TSCC and 17 ICI-treated patients who underwent glossectomy without any other prior therapy. Comprehensive profile analyses employed multiplex immunofluorescence tissue imaging....
Programmed death-1 (PD-1), a member of the CD28 family, has been identified. PD-1 is involved in negative regulation some immune responses. We evaluated role PD-ligand 1 (PD-L1) graft arterial disease (GAD) cardiac allografts and smooth muscle cells (SMCs).C57BL/6 murine hearts were transplanted into B6.C-H2<bm12>KhEg mice for examination GAD. PD-L1 was expressed SMCs thickened intima coronary arteries, administration anti-PD-L1 monoclonal antibody (mAb) enhanced progression GAD (luminal...
Abstract Keratinocytes (KCs) may play important roles for maintenance of peripheral tolerance in the upper layers skin. Coinhibitory signals mediated via programmed death (PD)-1 and its ligand B7-H1 (PD-L1/CD274) are crucial downregulation T cell immune responses tolerance. In this study, to investigate role KC-expressed regulation responses, we generated transgenic (tg) mice overexpressing under control keratin 14 (K14) promoter (K14-B7-H1 tg). K14-B7-H1 tg displayed impaired contact...
Understanding the tumor immune microenvironment is becoming increasingly necessary for risk prediction and treatment selection. In particular, oral cancer has various immunosuppressive characteristics in microenvironment. Therefore, we comprehensively assessed profiles of tongue squamous cell carcinoma (OTSCC).Multiplex immunofluorescence tissue imaging analyses were performed to evaluate at invasive front 60 OTSCC surgical specimens. We analyzed 58 parameters including density proportion...
Summary Leucocyte‐associated immunoglobulin‐like receptor‐1 (LAIR‐1) is a membrane receptor of the immunoglobulin (Ig) superfamily that expressed on most types haematopoietic cells, and delivers inhibitory signals through interacting with collagens. In order to elucidate immunological functions LAIR‐1 in vivo , we established transgenic mice expressing chimeric protein composed extracellular domain fused an Ig tag (LAIR‐1–Ig), which acts as decoy by competing endogenous LAIR‐1. The showed...
Oral focal mucinosis, the oral counterpart of cutaneous is a rare disease. As it has no characteristic clinical or radiological features, diagnosis established by histopathological and immunohistological examination. We present three cases mucinosis occurring in retromolar (which extremely rare) gingival regions.Case 1 involved 26-year-old Japanese man with radiolucency right region on panoramic radiograph computed tomography; obvious protrusion was observed region. This finding clinically...
Background: The scapular flap is the most versatile composite used for mandibular reconstruction. purpose of this study was to review and summarize findings cases reconstruction with a describe associated outcomes complications. Methods: A total 208 microvascular free flaps were performed in 205 patients from 2003 2018. This involved retrospective all eligible patients’ medical records. Results: There seven (3.4 percent) thrombosis. Postoperative bone union achieved by 201 patients, except...