A5004910333- Galectins and Cancer Biology
- Biomarkers in Disease Mechanisms
- Signaling Pathways in Disease
- Alkaline Phosphatase Research Studies
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Metabolism and Diseases
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Dental Radiography and Imaging
- Polysaccharides and Plant Cell Walls
- Macrophage Migration Inhibitory Factor
- Toxin Mechanisms and Immunotoxins
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Genomic variations and chromosomal abnormalities
- Microbial Metabolites in Food Biotechnology
- Voice and Speech Disorders
- Female Genital Mutilation/Cutting Issues
- Tattoo and Body Piercing Complications
- Oropharyngeal Anatomy and Pathologies
- Ear and Head Tumors
- Hedgehog Signaling Pathway Studies
- Nutrition and Health in Aging
Tokyo Medical and Dental University
2012-2024
Wayne State University
2013-2019
NTT Medical Center
2019
The Barbara Ann Karmanos Cancer Institute
2017-2019
Shizuoka City Hospital
2018
Recently, the epithelial-to-mesenchymal transition (EMT) has been demonstrated to contribute normal and disease processes including cancer progression. To explore EMT-suppressive microRNAs (miRNAs), we established a cell-based reporter system using stable clone derived from pancreatic cell line, Panc1, transfected with construct containing promoter sequence of CDH1/E-cadherin in 5′ upstream region ZsGreen1 gene. Then, performed function-based screening 470 synthetic double-stranded RNAs...
Patients with bone cancer metastasis suffer from unbearable pain and fractures due to remodeling. This is caused by tumor cells that disturb the microenvironment. Here, we have investigated role of tumor-secreted sugar-binding protein, i.e., galectin-3, on osteoblast differentiation report it downregulates expression markers, e.g., RUNX2, SP7, ALPL, COL1A1, IBSP, BGLAP, treated human fetal (hFOB) cells. Co-culturing hFOB breast BT-549 prostate LNCaP harboring galectin-3 has resulted in...
Papaya (Carica papaya L.) is a fleshy fruit with rapid pulp softening during ripening. Ripening events are accompanied by gradual depolymerization of pectic polysaccharides, including homogalacturonans, rhamnogalacturonans, arabinogalactans, and their modified forms. During intermediate phases ripening, partial pectin to small size decreased branching had enhanced anti-cancer properties. These properties were lost continued decomposition at later Pectin extracted from ripening markedly cell...
Management of bone metastasis remains clinically challenging and requires the identification new molecular target(s) that can be therapeutically exploited to improve patient outcome. Galectin-3 (Gal-3) has been implicated as a secreted factor alters microenvironment. Proteolytic cleavage Gal-3 may also contribute malignant cellular behaviors, but not addressed in cancer metastasis. Here, we report modulates osteolytic tumor microenvironment presence RANKL. was localized on osteoclast cell...
Nonalcoholic steatohepatitis (NASH) is related to metabolic dysregulation and the perturbation of endoplasmic reticulum (ER) homeostasis that frequently develops into hepatocellular carcinoma (HCC). Gp78 E3 ligase, which regulates reticulum-associated degradation (ERAD) by ubiquitinylation misfolded ER proteins. Here, we report upon ageing (12 months), gp78-/- mice developed obesity, recapitulating age-related human NASH. Liver histology revealed typical steatosis, hepatic inflammation...
While chemically and thermally modified citrus pectin (MCP) has already been studied for health benefits, it is unknown how size-fractionated oligo- polysaccharides differentially affect cancer cell behavior. We produced MCP fractionated by molecular size to evaluate the effect these polymers have on cells. MCP30/10 (between 30 10 kDa) had more esterified homogalacturonans (HG) fewer rhamnogalacturonans (RG-I) than MCP30 (higher kDa), while MCP10/3 3 showed higher amounts of type I...
// Yosuke Harazono 1 , Dhong Hyo Kho Vitaly Balan 2 Kosei Nakajima Tianpeng Zhang Victor Hogan and Avraham Raz Departments of Oncology Pathology, School Medicine, Wayne State University, Karmanos Cancer Institute, Detroit, MI Everon Biosciences, Buffalo, NY Correspondence: Avraham, email: Keywords : Galectin-3 (Gal-3), Bax, doxorubicin (DXR), apoptosis, thyroid cancer Received August 13, 2014 Accepted September 15, Published 16, Abstract cells survive escaping normal apoptosis the blocks in...
// Yosuke Harazono 1, 2 , Dhong Hyo Kho 1 Vitaly Balan 3 Kosei Nakajima Victor Hogan Avraham Raz Departments of Oncology and Pathology, School Medicine, Wayne State University, Karmanos Cancer Institute, Detroit, MI 48201, USA Department Maxillofacial Surgery, Tokyo Medical Dental Bunkyo-ku, 113-8510, Japan Everon Biosciences, Buffalo, NY 14203, Correspondence to: Raz, e-mail: raza@karmanos.org Keywords: galectin-3, Na+/K+-ATPase, multidrug resistance, P-glycoprotein, phosphorylation...
There are a few reports that focus on radiotherapy (RT) and cetuximab (CET) therapy exclusively for oral cancer. This retrospective study aimed to investigate the efficacy safety of RT CET locally advanced (LA) or recurrent/metastatic (R/M) squamous cell carcinoma (OSCC). Seventy-nine patients from 13 hospitals who underwent LA R/M OSCC between January 2013 May 2015 were enrolled in study. Response, overall survival (OS), disease-specific (DSS), adverse events investigated. The completion...
The nerve to the mylohyoid muscle has been well studied but there are no specific anatomical landmarks for identifying it.Therefore, we aimed identify localizing in submandibular region.Sixteen sides from eight embalmed Caucasian cadaveric heads were used this study.The mean age at time of death specimens was 80.3 years.The anterior and posterior bellies digastric muscle, submental artery, dissected verify their relationships with muscle.The found medial lateral belly border on all...
Marsupialization is a dependable choice for mandibular unicystic ameloblastoma (UA) management. However, investigations regarding its speed of shrinkage (SS) and reduction rate (RR) are lacking. This case report highlights the treatment huge UA with high SS RR using marsupialization before secondary surgery.
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant nevus disease characterized by multiple manifestations, primarily café-au-lait macules and neurofibromas. Here, we present the case of NF1 patient with 47,XYY mosaicism whose diagnosis was prompted on skin mandibular Targeted next-generation sequencing patient’s blood sample revealed a novel frameshift mutation in (NM_000267.3:c.6832dupA:p.Thr2278Asnfs*8) that considered pathogenic variant.
The transcription factor tumour protein 63, encoded by the TP63 gene, is a regulator of epidermal development. Heterozygous mutations in cause variety human ectodermal dysplasia disorders, including ankyloblepharon-ectodermal defects-cleft lip/palate syndrome, ectrodactyly, dysplasia, cleft split hand/foot malformation 4, Rapp-Hodgkin limb mammary and acro-dermato-ungual-lacrimal-tooth syndrome. There are genotype-phenotype correlations some these syndromes, number cases with overlapping...
Ameloblastoma is a benign odontogenic tumor with locally aggressive characteristics and high recurrence rate. The aim of this study was to evaluate the risk factors for recurrence, determine appropriate treatment ameloblastoma. conducted in Department Maxillofacial Surgery, Tokyo Medical Dental University Hospital, covering years 1992–2018. following were recorded analyzed: patient demographic data, site maximum size, World Health Organization classification, method, positional relationship...
<p>Materials and Methods for Tissue microarray, Immunofluorescence, Quantitative Real-Time PCR, Proteomics analysis, Co-immunoprecipitation, Co-culture.</p>
<p>Human and Mouse osteoclast precursor cells express Gal-3.</p>