A5060992498- RNA modifications and cancer
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cleft Lip and Palate Research
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Radiopharmaceutical Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- Head and Neck Cancer Studies
- Hedgehog Signaling Pathway Studies
- Medical Imaging Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral and gingival health research
- Bone Metabolism and Diseases
- Pharmacogenetics and Drug Metabolism
- Cancer and Skin Lesions
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Silicon and Solar Cell Technologies
- Osteomyelitis and Bone Disorders Research
- Skin and Cellular Biology Research
Tokyo Medical and Dental University
2015-2024
Musashino University
2020
Tokushima University
2012-2014
National Medical Research Center of Dentistry and Maxillofacial Surgery
2011
Central Research Institute of Electric Power Industry
2006
Tokyo University of Technology
2006
National Institute of Advanced Industrial Science and Technology
2006
Nagoya University
1986-2001
Tosei General Hospital
1999-2000
Setsunan University
1999
THBS1 (thrombospondin-1) is the extracellular matrix (ECM) protein that affects diverse cellular activities. It constitutes tumor stroma, but role of in oral squamous cell carcinoma (OSCC) development unclear. The aim this study was to clarify relevance pathogenesis OSCC.The expression examined 44 OSCC by immunohistochemical analysis and 43 cDNA microarray analysis. Cell culture experiments were conducted using human lines HSC3 HO1N1 mouse fibroblast ST2 cells examine effect TGFB1 on...
Sakamoto K, Aragaki T, Morita K‐i, Kawachi H, Kayamori Nakanishi S, Omura Miki Y, Okada N, Katsube Takizawa T & Yamaguchi A (2011) Histopathology 58, 531–542 Down‐regulation of keratin 4 and 13 expression in oral squamous cell carcinoma epithelial dysplasia: a clue for histopathogenesis Aims: This study aimed to identify relevant subtypes that may associate with the pathogenesis neoplasms. Methods results: Expression all was examined by cDNA microarray analysis 43 (OSCC) cases....
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival human cancer. PIK3CA mutations, which are found many cancer patients, activate the PI3K pathway, resulting development progression. We previously identified CH5132799 as novel inhibitor. Thus, this study aimed to clarify biochemical antitumor activity of elucidate correlation between response genetic alterations pathway.Kinase inhibitory was profiled cell-free assays. A large panel...
Calcifying cystic odontogenic tumors (CCOTs) are benign that form abnormally keratinized ghost cells. Mutations in CTNNB1, which encodes beta-catenin, have been implicated the development of these tumors, but a causal relationship has not definitively established. Thus, mutational hot spots 50 cancer genes were examined by targeted next-generation sequencing 11 samples CCOT. other genes, observed 10 cases. These mutations constitutively activate beta-catenin signaling abolishing...
Keratin subtypes are selectively expressed depending on the cell type. They not only provide structural support, but regulate metabolic processes and signaling pathways that control growth of epithelium. KRT17 (keratin 17) is induced in regenerative epithelium acts diverse pathways. Here, we demonstrate invariably permanently oral squamous carcinoma (OSCC), as revealed by immunohistochemistry cDNA microarray analysis. Two representative OSCC lines; KRT17-weakly expressing Ca9-22 KRT17-highly...
ABSTRACT Mechanical force or mechanical stress modulates intracellular signal pathways, including the mitogen-activated protein kinase (MAP kinase) cascades. In our system, cell stretching activated and contraction inactivated all three MAP pathways (MKK1/2-extracellular signal-regulated (ERK), MKK4 (SEK1)-cJun N-terminal (JNK) MKK3/6-p38 pathways). However, little is known about molecular mechanisms that link to To test whether Ras Rap1 are possible components in stretch-activated we...
Oral leukoplakia can be treated using a variety of treatment procedures; however, the lesions recur in many cases irrespective procedure used. The rate recurrence was from 7.7% to 38.1%. This study aims identify important factors that lower risk oral by curative surgical resection.The clinical records 52 patients with (53 lesions) who underwent resection between 2004 and 2009 were retrospectively analyzed for recurrence, outcome, epithelial dysplasia, lesion location, margins.The following...
Genome research using appropriately collected pathological tissue samples is expected to yield breakthroughs in the development of biomarkers and identification therapeutic targets for diseases such as cancers. In this connection, Japanese Society Pathology (JSP) has developed “The JSP Guidelines on Handling Pathological Tissue Samples Genomic Research” based an abundance data from empirical analyses stored under various conditions. should be appropriate sites within surgically resected...
Drug clearance and drug-drug interactions are essential for pharmacokinetic assessment. However, current in vitro systems animal scale-up approaches often fail to accurately predict drug disposition mediated by metabolizing enzymes, especially uridine diphosphate-glucuronosyltransferase (UGT). This study demonstrates how UGT-mediated humans can be predicted using hu-PXB mice (cDNA-uPA/severe combined immunodeficiency (SCID) transplanted with human-derived hepatocytes). To estimate human...
Background LAMC 2 plays an important role in cancer invasion. The aim of this study was to (i) compare the immunoexpression different stages oral squamous cell carcinoma ( OSCC ), early and advanced, (ii) evaluate as a marker malignant transformation leukoplakia. Materials Methods expression examined by immunohistochemistry 50 surgical specimens advanced assembled tissue microarrays, cDNA microarray 43 . further 39 93 incisional biopsy leukoplakia tongue, which exhibited epithelial...
Background: Oral squamous cell carcinoma (OSCC) is common type of human cancer, but little known about the molecular mechanisms deciding on this malignancy. Comprehensive gene expression profiling essential for understanding OSCC. Methods: cDNA microarray was used to analyze patterns 16 617 genes in nine OSCC patients. Results: Forty‐seven with altered among all cases were extracted. The ontology these 47 classified into 10 categories. To validate data, genes, including TGFBI , FADD and...
Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in properties. The basal cells oral express 5 (K5), K14, K15 K19, but tumors unclear. To address this issue seek possible diagnostic application, we examined expression these keratins squamous carcinoma (OSCC) intraepithelial neoplasm (SIN). cDNA microarray analysis 43 OSCC revealed slight...
Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or a sporadic lesion. Gene mutations and loss heterozygosity (LOH) the hedgehog receptor PTCH1 plays an essential role in pathogenesis KCOT. However, some KCOT cases lack evidence for gene alteration PTCH1, suggesting that other genes pathway may be affected. PTCH2 SUFU participate occurrence GS-associated tumors, but their roles development are unknown. To elucidate these genes, we enrolled 36 patients study to...
J Oral Pathol Med (2010) 39: 525–532 Background: The Fas-associated death domain-containing protein, FADD, is an adaptor for relaying apoptotic signals. However, recent studies have shown that FADD also plays important role in the growth and regulation of cell cycle. purpose this study was to elucidate oral squamous carcinoma (SCC). Methods: DNA amplification from 30 samples tongue SCC analyzed using real-time PCR protein expression 60 immunohistochemistry. Results: amplifications were...
A 26‐year‐old woman presented with pain in the left hypochondrium, for which pancreatectomy and splenectomy was performed, total gross excision of a mass. tumor measuring 11 × 9 cm found pancreas. On cut surface there were two cysts filled necrotic substance hemorrhagic content. Spindle or ovoid‐shaped cells, sarcomatous component, had diffusely infiltrated along inner side walls one cyst. Osteoclast‐like giant cells (OGC) also contained component. Adenoma components mucinous epithelium foci...
Abstract Treatment of advanced oral squamous cell carcinoma ( OSCC ) requires the integration multimodal approaches. The aim this study was to identify predictors tumor sensitivity preoperative radiotherapy/chemotherapy for in order allow oncologists determine optimum therapeutic strategies without associated adverse effects. Here, protein expression profiles formalin‐fixed paraffin‐embedded FFPE tissue samples from 18 patients, termed learning cases, who received chemotherapy and/or...