A5053699794- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Sarcoma Diagnosis and Treatment
- Orthodontics and Dentofacial Orthopedics
- Cleft Lip and Palate Research
- Dental Radiography and Imaging
- Genomic variations and chromosomal abnormalities
- Oral Health Pathology and Treatment
- Nasal Surgery and Airway Studies
- Cancer-related Molecular Pathways
- Meningioma and schwannoma management
- Hedgehog Signaling Pathway Studies
- Dental Research and COVID-19
- Neurofibromatosis and Schwannoma Cases
- Advanced X-ray and CT Imaging
Tokyo Medical and Dental University
2018-2024
The University of Tokyo
2018
Bromodomain Containing 4 (BRD4) mediates transcriptional elongation of the oncogene MYC by binding to acetylated histones. BRD4 has been shown play a critical role in tumorigenesis several cancers, and BRD4-NUT fusion gene is driver NUT midline carcinoma (NMC), rare but highly lethal cancer. microRNAs (miRNAs) are endogenous small non-coding RNAs that suppress target expression complementary mRNA sequences. Here, we show miR-3140, which was identified as novel tumor suppressive miRNA...
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant nevus disease characterized by multiple manifestations, primarily café-au-lait macules and neurofibromas. Here, we present the case of NF1 patient with 47,XYY mosaicism whose diagnosis was prompted on skin mandibular Targeted next-generation sequencing patient’s blood sample revealed a novel frameshift mutation in (NM_000267.3:c.6832dupA:p.Thr2278Asnfs*8) that considered pathogenic variant.
The transcription factor tumour protein 63, encoded by the TP63 gene, is a regulator of epidermal development. Heterozygous mutations in cause variety human ectodermal dysplasia disorders, including ankyloblepharon-ectodermal defects-cleft lip/palate syndrome, ectrodactyly, dysplasia, cleft split hand/foot malformation 4, Rapp-Hodgkin limb mammary and acro-dermato-ungual-lacrimal-tooth syndrome. There are genotype-phenotype correlations some these syndromes, number cases with overlapping...
Abstract Bromodomain Containing 4 (BRD4) mediates transcriptional elongation of the oncogene MYC by binding to acetylated histones. BRD4 has been shown play a critical role in tumorigenesis several cancers, and BRD4-NUT fusion gene is driver NUT midline carcinoma (NMC), rare but highly lethal cancer. microRNAs (miRNAs) are endogenous small non-coding RNAs that suppress target expression complementary mRNA sequences. Here, we show miR-3140, which was identified as novel tumor suppressive...