A5042082981- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Lung Cancer Treatments and Mutations
- Oral and gingival health research
- Brain Metastases and Treatment
- Carcinogens and Genotoxicity Assessment
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Glutathione Transferases and Polymorphisms
- T-cell and Retrovirus Studies
- Molecular Biology Techniques and Applications
Saitama Cancer Center
2005-2023
Nippon Dental University Hospital
2018-2020
Tohoku University
2019
RIKEN Center for Advanced Intelligence Project
2019
Asahi University
2018-2019
Tokyo Medical and Dental University
2013-2018
Soka Municipal Hospital
2017
Nara Medical University
2012
Saitama Prefecture
2009
National Defense Medical College
2002
We have recently reported EBV+ B-cell lymphoproliferative disorders (LPD) occurring predominantly in elderly patients, which shared features of neoplasms arising the immunologically deteriorated patients despite no predisposing immunodeficiency and were named as senile or age-related LPDs. To further characterize this disease, LPDs compared with EBV-negative diffuse large lymphomas (DLBCL).Among 1,792 LPD cases, 96 cases available clinical data set enrolled for present study. For control...
An individual difference in the susceptibility to chemical carcinogens is one of most important factors estimate risk human cancer. Recently, it has been reported that genetic for tobacco-related cancers associated with polymorphisms CYP1A1 and GSTM1 genes terms genotype frequencies cigarette smoking dose. In this study, we investigated inter-individual genetically determined oral squamous cell carcinoma (SCC) relation dose a Japanese population. DNA samples were obtained from both patients...
Airway occlusion by mucus in chronic obstructive disease (COPD) is associated with a poor prognosis. We hypothesised that tiotropium has the ability to inhibit neutrophil elastase (NE)-induced goblet cell metaplasia mice and mucin production vitro . On days 1, 4, 7, or vehicle was administered C57BL/6 inhalation they were allowed intranasally aspirate human NE. Bronchoalveolar lavage fluid (BALF) lung sections analysed on 8, 11 14. The effect of late administration NE aspiration also...
The identification of genes that participate in melanomagenesis should suggest strategies for developing therapeutic modalities. We used a public array comparative genomic hybridization (CGH) database and real-time quantitative PCR (qPCR) analyses to identify the AMP kinase (AMPK)-related NUAK2 as candidate gene melanomagenesis, we analyzed its functions melanoma cells. Our had identified locus at 1q32 where gain is strongly associated with tumor thickness, qPCR regression locus....
For the doctors and other medical staff treating oral cancers, it is necessary to standardize basic concepts rules on cancers progress in treatment, research diagnosis. Oral are integrated head neck applied general cancer, but considered that more detailed based characteristics of essential. The objectives this 'General Rules for Clinical Pathological Studies Cancer' contribute development diagnosis, treatment correct useful information clinical, surgical, pathological image findings...
Background LAMC 2 plays an important role in cancer invasion. The aim of this study was to (i) compare the immunoexpression different stages oral squamous cell carcinoma ( OSCC ), early and advanced, (ii) evaluate as a marker malignant transformation leukoplakia. Materials Methods expression examined by immunohistochemistry 50 surgical specimens advanced assembled tissue microarrays, cDNA microarray 43 . further 39 93 incisional biopsy leukoplakia tongue, which exhibited epithelial...
To assess tissue characterization of oral tongue cancer and prediction subclinical cervical lymph node metastasis, we investigated whether intraoral ultrasonography could be used in conjunction with a computer-aided diagnosis (CAD) system.The study population comprised 109 patients presurgical, clinical T1N0 or T2N0 squamous cell carcinoma who underwent partial glossectomy. All the were examined by preoperative postoperative ex vivo ultrasonography. evaluate ultrasonic images quantitatively,...
Ameloblastic carcinoma (AC) is a rare malignant odontogenic neoplasm that tends to occur in the mandible rather than maxilla. This malignancy classified as tumor combines morphological features of ameloblastoma and carcinoma, regardless presence or absence metastasis. In addition, AC has been into two types, primary secondary. The former develops de novo latter by transformation pre-existing benign ameloblastoma. present study describes case 22-year-old patient with A review literature...
Abstract Three cases of primary non-Hodgkin's lymphoma the larynx are described. Histologically, two tumours belonged to category low grade B-cell lymphomas small cell type (extranodal marginal zone and lymphoplasmacytoid lymphoma), third was classified as a peripheral T-cell unspecified type. The clinical stage IE in cases, IV another case. In complete remission obtained with radical radiotherapy. But other case, which histologically lymphoma, response radiotherapy poor, surgery required....
We conducted three-dimensional (3D) reconstruction of oral tongue squamous cell carcinoma (OTSCC) using serial histological sections to visualize the architecture invasive tumors. Fourteen OTSCC cases were collected from archival paraffin-embedded specimens. Based on a pathodiagnostic survey whole cancer lesions, core tissue specimen (3 mm in diameter) was dissected out deep invasion front paraffin microarray. Serial (4 μ m thick) double immunostained with pan-cytokeratin and Ki67 antibodies...
Three abnormal shadows were detected in the right lung on chest X-ray films and computed tomography a 75-year-old woman during follow-up for idiopathic thrombocytopenic purpura. Because definitive diagnosis was not obtained through general examinations, exploratory thoracotomy performed treatment. The main lesion middle lobe diagnosed as mucosa-associated lymphoid tissue (MALT) lymphoma according to histopathological findings, cytogenic studies reverse transcriptase-polymerase chain reaction...
To identify molecular signatures and establish a new diagnostic model for progressive oral squamous cell carcinoma (OSCC). Total RNAs were isolated from primary OSCCs both node-positive -negative patients used in cDNA microarray analysis. marker genes representing malignant phenotype, their expression was further examined by quantitative reverse transcription-PCR (QRT-PCR) 64 OSCC tissues. Using Fisher's linear discriminant analysis (LDA) fitted with stepwise increment method, we created...
Primary tumor (PT) heterogeneity can significantly affect the genetic profile of clones at metastatic sites. To understand mechanisms underlying metastasis, we compared paired PT and lymph node (MLN) samples obtained from patients with oral tongue squamous cell carcinoma (OTSCC). Large‐scale profiling was performed on PT‐MLN 10 OTSCC using high‐density single‐nucleotide polymorphism microarrays. We MLN to identify common specific copy number alterations copy‐neutral loss‐of‐heterozygosity...
Stromal melanocytic foci (SMF) of the uterine cervix, which are known as extracutaneous blue nevus, were examined in step sections cervix. A total 189 specimens surgically excised for leiomyoma, adenomyosis etc., studied. The over‐all incidence SMF cervix was 28.6% (54/189 cases). these lesions increased with age, and they most prevalent sixth decade life (12/30 cases, 40%). presented more often anterior wall than posterior wall. Most less 1 mm size. No case demonstrated expansive tumorous...