A5049548990- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Cancer and Skin Lesions
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Skin Diseases and Diabetes
- Drug-Induced Adverse Reactions
- Psoriasis: Treatment and Pathogenesis
- Cell Adhesion Molecules Research
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Food Allergy and Anaphylaxis Research
- Autoimmune and Inflammatory Disorders
- Plant Pathogens and Fungal Diseases
- T-cell and B-cell Immunology
- Salivary Gland Disorders and Functions
- Dermatological and Skeletal Disorders
Tokyo Medical and Dental University
2000-2020
Sumitomo Seika Chemicals (Japan)
2014-2017
Hyogo Medical University
2017
Kitasato University
1986-2013
Yokohama Rosai Hospital
2013
The University of Tokyo
2010-2012
Nippon Steel (Japan)
1988-2012
Tokyo University of Science
2012
Center for High Pressure Science and Technology Advanced Research
2012
Doshisha University
2009
Abstract PGD2 plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of gene to investigate functional cutaneous inflammatory responses. CRTH2-deficent were fertile grew normally. Ear-swelling responses induced by hapten-specific IgE less pronounced mice, giving 35–55% normal mice. Similar results seen treated with hemopoietic...
CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice. To assess the role of ectopic CD40L expression development SLE, we have established transgenic mice expressing cells. Some 12- to 14-mo-old CD40L-transgenic spontaneously produced autoantibodies such as antinuclear Abs, anti-DNA antihistone Abs. Moreover, approximately half developed glomerulonephritis immune-complex deposition, whereas kidneys normal...
• Numbers of mast cells were quantitated in the lesions diffuse scleroderma and morphea. Mast increased then decreased number papillary dermis scleroderma. No significant change cell numbers was noted reticular dermis. with fine collagen bundles (grade 2 skin scleroderma) homogeneous 3 scleroderma). The total grade 1 In morphea a reduced lesions. It is suggested that play an important role fibrotic process skin. (<i>Arch Dermatol</i>1987;123:205-208)
Optically active aluminum complexes such as Schiff base, binuclear β-ketoiminate, and bisprolinol were found to promote asymmetric alternating copolymerizations of carbon dioxide cyclohexene oxide. The base complexes–tetraethylammonium acetate afforded isotactic poly(cyclohexene carbonate)s with low enantioselectivities. Lewis bases having two coordinating sites utilized enhance activity selectivity based on the structure β-ketoiminate clarified by X-ray crystallography. [2gAlMe]2–bulky...
Contact hypersensitivity (CHS) is thought to be mainly associated with the activation of T helper type 1 (Th1) cells. However, there also evidence that Th2 cells or cytokines play a role in development CHS. To analyze functional contribution interleukin (IL)-4 and IL-13, signal transducer activator transcription 6 (STAT6)-deficient (STAT6(-/)-) wild-type (wt) control C57BL/6 mice were contact sensitized 5% 2,4,6-trinitrochlorobenzene (TNCB), 0.5% 2,4-dinitrofluorobenzene, 4-ethoxyl...
For manufacturing the steel plates with good mechanical properties by Thermo-Mechanical Control Process (TMCP), conditions are necessary to be controlled in an integrated manner through reheating step accelerated cooling step. The present mathematical model for prediction of microstructural evolution and produced TMCP enables this control. report describes flow each equation comparison between calculated results data obtained rolling experiments.The consists four modules such as Reheating,...
For the first time, we performed an epidemiological study of SSc in Japan to factors influencing prognosis, survival rate and cause death Japanese patients compare our data with those from foreign countries. Prognosis 496 progressive systemic sclerosis (SSc) was analyzed based on clinical described case cards provided by members Scleroderma Research Committee Ministry Health Welfare. The essential observation period 5 20 years, at ending 1994. Ninety died (males 11, females 79). age onset...
Abstract To investigate the role of cell surface glycosaminoglycans (GAGs), including heparan sulfate (HS), on HIV‐1 infection in human T cells, binding and were determined after treatment T‐cell lines CD4 + cells from normal peripheral blood mononuclear (PBMC) with GAG‐degrading enzyme or a GAG metabolic sulfation inhibitor. Heparitinase I (hep I) sodium chlorate prevented HIV‐1/IIIB to MT‐4 as revealed by indirect immunofluorescence procedures, thereby inhibiting infection. Hep was less...
Abstract Serum lactate dehydrogenase activity (LDH) was elevated in most cases with the severe type of atopic dermatitis (AD). We examined whether LDH correlated specifically clinical courses and severity AD skin eruptions. Blood eosinophil numbers (Eo), its isoenzymes, serum IgE (IgE) levels eighty patients were measured before after treatment. In improved groups, Eo decreased or returned to normal values contrast, both increased who worsened Thus changes well picture. However, did not...
Journal Article The role of dermal blood vessels in the pathogenesis malignant atrophic papulosis (Degos' disease): A STUDY OF TWO CASES USING ENZYME HISTOCHEMICAL, FIBRINOLYTIC, ELECTRON‐MICROSCOPICAL AND IMMUNOLOGICAL TECHNIQUES Get access MARTIN M. BLACK, BLACK Department Histopathology, Institute Dermatology, London WC2H 7BJ, and Immunology, Homerton Grove, E9 6BX Search for other works by this author on: Oxford Academic Google Scholar KIYOSHI NISHIOKA, NISHIOKA GERALD LEVENE British...
Abstract The nail is commonly involved in psoriasis; however, very few therapies are satisfactory. In this study, we treated for 20 cases of psoriasis vulgaris with involvement topical anthralin therapy. An ointment 0.4–2.0% petrolatum was applied to the affected bed once a day and washed away water after 30 minutes. Then, 10% triethanolamine cream prevent undesired pigmentation. Within five months therapy, twelve out twenty psoriatic patients (60%) showed moderate obvious improvement, four...