A5114043860- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Welding Techniques and Residual Stresses
- Circadian rhythm and melatonin
- Protease and Inhibitor Mechanisms
- Fatigue and fracture mechanics
- RNA Interference and Gene Delivery
- Microstructure and Mechanical Properties of Steels
- Multiple Sclerosis Research Studies
- Mast cells and histamine
- Inflammatory Bowel Disease
- Complementary and Alternative Medicine Studies
Kyowa Kirin (Japan)
2018-2025
Keio University
2012
Tokyo Medical and Dental University
2005-2006
Abstract PGD2 plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of gene to investigate functional cutaneous inflammatory responses. CRTH2-deficent were fertile grew normally. Ear-swelling responses induced by hapten-specific IgE less pronounced mice, giving 35–55% normal mice. Similar results seen treated with hemopoietic...
What is this summary about? This describes the results of ProLOGUE study, which tested effects brodalumab in Japanese people with plaque psoriasis using outcomes mostly reported by study participants. happened study? Seventy-three adults received for 48 weeks. Doctors on extent and severity psoriasis, while participants its health-related quality life, overall health status, severity, itch, skin pain, anxiety depressive symptoms, sleep, general activity, work productivity income loss, how...
It is important to understand the differences in patient–physician perceptions and factors affecting satisfaction with treatment patients systemic sclerosis (SSc). This web-based survey (conducted Japan March 2023) targeted aged ≥ 18 years SSc physicians hospitals 20 beds seeing 3 monthly. Physicians answered similar questions. Responders were 301 (63.8% female; 47.5% limited cutaneous SSc; 44.9% diffuse SSc) 129 (51.2% rheumatologists; 20.9% dermatologists). The most common problematic...
Plaque psoriasis significantly affects patients' health-related quality of life. To aid treatment decisions, not only objective assessment by physicians but also subjective patients is important.To assess the significance Dermatology Life Quality Index (DLQI) evaluation at time biologics introduction in clinical practice Japanese with plaque psoriasis.This was a single-arm, open-label, multicenter study. At baseline, Psoriasis Area and Severity (PASI) DLQI scores were measured stratified...
Evidence on treatment effectiveness in patients with psoriasis having anxiety or depressive symptoms helps shared decision-making. This single-arm, open-label, prospective study-ProLOGUE-was conducted to assess the of brodalumab self-assessed and Japanese psoriasis.Patients aged ≥ 18 years plaque without peripheral arthritis who had responded inadequately current therapies were enrolled at 15 facilities received 210 mg subcutaneously.A total 73 (male, 82%; median age, 54 years). The...
Small interfering of RNA (siRNA) technology has the potential to be a next-generation therapy. However, naked siRNA does not have high transfection efficiency and is rapidly degraded after systemic injection, so an appropriate drug delivery system (DDS) required for clinical use. Several systems been assessed, clinically focusing on hepatocyte or cancer tissue using siRNA. targeting immune cells still challenging, new DDS required. In this study, we prepared lipid nanoparticles (LNP)...
Abstract Macrophage-derived chemokine (MDC) CCL22 is a potent chemoattractant for Th2 cells and has been implicated in Th2-predominant allergic inflammation. In the present study, we demonstrated that basophils produce MDC response to monomeric IgE. trinitrophenyl (TNP)-IgE transgenic mice, serum levels of were persistently higher than wild-type mice. The i.v. administration TNP-specific IgE mice transiently induced an elevation MDC, which appeared be mediated by FcεRI, as no increase was...
Abstract Psoriasis poses a substantial economic burden by reducing the work productivity of affected patients. We aimed to evaluate negative impact plaque psoriasis on and effectiveness brodalumab in improving impairment real‐life employed This analysis was conducted patients from ProLOGUE, an open‐label, multicenter, prospective cohort study (Japan Registry Clinical Trials identifier: jRCTs031180037). Outcomes included association Work Productivity Activity Impairment‐Psoriasis (WPAI‐PSO)...
Patients with psoriasis report impaired health-related quality of life (HRQoL; Dermatology Life Quality Index score ≥ 2) even after achieving clear or almost-clear skin biologic treatment.To assess the effectiveness brodalumab in HRQoL improvement and factors associated incomplete Japanese patients psoriasis.As a part single-arm, open-label, multicenter, prospective ProLOGUE study (Japan Registry Clinical Trials identifier: jRCTs031180037), were treated 210 mg subcutaneous daily clinical...
Abstract Itching and skin pain are bothersome symptoms of psoriasis, but evidence is limited regarding the treatment effectiveness on these in daily clinical settings. We assessed changes levels itching after brodalumab Japanese patients with psoriasis using patient‐reported outcomes (PROs). Patients who have inadequate response to existing treatments were enrolled single‐arm, open‐label, multicenter, prospective ProLOGUE study received 210 mg subcutaneously practice. Psoriasis Area Severity...
Abstract Previous clinical studies have shown that efficacy and serum brodalumab levels are dose dependent in patients with psoriasis receiving the same of during study. This study aimed to investigate association between dosage, levels, Japanese plaque dosage variations was a post hoc exploratory analysis 108‐week, multicenter, open‐label extension study, which changed into post‐marketing surveillance following approval Japan. Eligible ( n = 129) received 140 mg every 4 weeks on Day 1;...
Abstract Psoriasis impacts various aspects of patients' health‐related quality life and is associated with sleep problems. However, research discussing the associations between interleukin‐17 blockage therapies problems in patients psoriasis insufficient. We aimed to assess effectiveness brodalumab alleviating real‐life plaque psoriasis. This analysis was part single‐arm, open‐label, multicenter, prospective, cohort study, ProLOGUE (study period October 2017–March 2020), which involved...