A5056470346- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Mast cells and histamine
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Sarcoidosis and Beryllium Toxicity Research
- Skin Diseases and Diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Cancer Cells and Metastasis
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Spondyloarthritis Studies and Treatments
- Glycogen Storage Diseases and Myoclonus
- Sympathectomy and Hyperhidrosis Treatments
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Vasculitis and related conditions
- Vascular Tumors and Angiosarcomas
- Carcinogens and Genotoxicity Assessment
Kansai Medical University
2015-2025
Tokai University
2023-2025
Advanced Dermatology
2008
Abstract A phase 3, multicenter, open‐label, 52‐week study investigated the efficacy and safety of adalimumab 80 mg at week 0 followed by 40 every other (option to escalate when necessary) in Japanese patients with generalized pustular psoriasis (GPP). Adults (aged 15–75 years) GPP, total skin score (overall erythema area, area pustules, edema area) 3 or more, pustules (skin score, ≥1) based on 2014 Dermatological Association severity index GPP were enrolled. The primary end‐point was...
Abstract Previous studies on family history of psoriasis showed that patients with a have an earlier onset the disease, but such in Japan are still limited. To elucidate characteristics familial psoriasis, we studied using West Psoriasis Registry, multi‐institutional registry operated by 26 facilities western part Japan, including university hospitals, community and clinics. This study enrolled 1847 registered between September 2019 December 2021, 199 (10.8%) having psoriasis. Patients had...
ABSTRACT Chronic inflammation in the tumour microenvironment (TME) via Th2‐polarisation promotes melanoma progression and metastasis, making it a target for immunotherapy. Interleukin (IL)‐4 is considered essential TME; however, its source remains unknown. Basophils have been postulated as one of sources. Basophil‐derived IL‐4 contributes to parasitic infections allergic diseases has implicated immunity. To identify basophil infiltration into TME human skin lesions sentinel lymph nodes...
Objective. The purpose of this study was to determine serum levels B-cell-activating factor (BAFF) and its clinical association in patients with sarcoidosis. Methods. Serum BAFF from 37 21 healthy subjects were examined by ELISA. angiotensin-converting enzyme (ACE), lysozyme IFN-γ sarcoidosis also measured. Isolated monocytes cultured IFN-γ, IL-4 or IL-10 their expression membrane soluble analysed flow cytometry Peripheral B cell subsets cytometry. the granuloma skin immunohistochemistry....
Plaque psoriasis significantly affects patients' health-related quality of life. To aid treatment decisions, not only objective assessment by physicians but also subjective patients is important.To assess the significance Dermatology Life Quality Index (DLQI) evaluation at time biologics introduction in clinical practice Japanese with plaque psoriasis.This was a single-arm, open-label, multicenter study. At baseline, Psoriasis Area and Severity (PASI) DLQI scores were measured stratified...
Evidence on treatment effectiveness in patients with psoriasis having anxiety or depressive symptoms helps shared decision-making. This single-arm, open-label, prospective study-ProLOGUE-was conducted to assess the of brodalumab self-assessed and Japanese psoriasis.Patients aged ≥ 18 years plaque without peripheral arthritis who had responded inadequately current therapies were enrolled at 15 facilities received 210 mg subcutaneously.A total 73 (male, 82%; median age, 54 years). The...
Psoriasis is a chronic, immune-mediated inflammatory skin disease with high negative impact on patient's quality of life. Secukinumab, the first interleukin 17A inhibitor, has been used for systemic treatment psoriasis, but its long-term, real-world retention rates in Japan have not fully investigated. In this multicenter, noninterventional, retrospective chart review study, rate secukinumab and effectiveness among patients psoriasis was evaluated up to 5 years. Data who received after...
Psoriasis is a systemic inflammatory disease known to affect survival in the presence of cerebral or cardiovascular comorbidities. However, no clear guidelines have been defined regarding extent vascular lesion testing that should be performed patients with psoriasis. We therefore coronary computed tomography angiography (CCTA) 88 Japanese psoriasis who visited Kansai Medical University Hospital between 2015 and 2019 determined ankle–brachial pressure index (ABI) for 44 these patients. CCTA...
Abstract We report herein a case of 72‐year‐old man with pityriasis rubra pilaris ( PRP ) that was refractory to conventional therapies. His skin lesions progressed generalized erythroderma despite anti‐interleukin IL )‐17A antibody therapy. Topical corticosteroids, emollients, systemic retinoid, methotrexate, cyclosporin and phototherapy yielded no therapeutic response. However, blockade ‐12/23 p40 dramatically improved his cutaneous lesions. Complete remission achieved 4 weeks after the...
The skin is responsible for a variety of physiological functions and critical wound healing repair. Therefore, the regenerative capacity important. However, stem cells maintaining acral epithelium had not previously been identified. In this study, we identified specific in that participate long-term maintenance sweat glands, ducts, interadnexal epidermis facilitate regeneration these structures following injury. Lgr6-positive Bmi1-positive were found to function as multipotent maintained...
A 64‐year‐old Japanese woman suffering from idiopathic thrombocytopenic purpura was treated with prednisolone. During the course of steroid withdrawal she developed parotid gland enlargement and cervical lymph node swelling multiple dome‐shaped red papules on her trunk upper limbs. On admission patient found to have numbness lower limbs (polyneuropathy), (organomegaly), high glucose level (endocrinopathy), Bence‐Jones protein‐κ in urine (M protein) skin hyperpigmentation, hypertrichosis...
Psoriasis is a skin disease with complicated pathophysiology that includes an extensive inflammatory cytokine network. Nevertheless, the relationship between psoriasis severity, levels, and coronary artery atherosclerosis remains poorly understood. Our aim was to find serum markers as potential candidates for cardiovascular (CVD) risk monitoring in patients psoriasis. Therefore, we examined via computed tomography angiography (CCTA), levels multiple immunoassays, patients' state. findings...
Abstract A 65‐year‐old Japanese woman with primary cutaneous CD8+ aggressive epidermotropic cytotoxic T‐cell lymphoma, a rare type poor prognosis, is presented. Oral bexarotene and vorinostat were ineffective, hematopoietic stem cell transplantation was scheduled. We stress that lymphoma should be treated bone marrow when available.