A5027404343- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- Nail Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer and Skin Lesions
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- Skin Protection and Aging
- Autoimmune and Inflammatory Disorders
- Lymphoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin and Cellular Biology Research
- Infectious Diseases and Mycology
- Hair Growth and Disorders
- Retinoids in leukemia and cellular processes
- Genetic and rare skin diseases.
- Cutaneous Melanoma Detection and Management
Tokai University
2016-2025
Tokai University Hospital
2019
Medical College of Wisconsin
2011-2012
Abstract Generalized pustular psoriasis ( GPP ) is a rare disease characterized by recurrent fever and systemic flushing accompanied extensive sterile pustules. The committee of the guidelines was founded as collaborative project between Japanese Dermatological Association Study Group for Rare Intractable Skin Diseases under Ministry Health, Labour, Welfare Research Project on Overcoming Diseases. aim to provide current information aid in treatment patients with Japan. Its contents include...
Abstract Cytokine components of Th17 pathway play vital roles in human psoriasis. Although much is known about TCR αβ T cells psoriasis, the role unconventional cells, including γδ unclear. In this study, using an IL-23 skin injection model psoriasiform dermatitis mice, we demonstrate that IL-22, IL-17A, and IL-23R were highly enriched a population CCR6+, γδ-low expressing (GDL) accumulated epidermis after injections. GDL distinct from resident γδ-high, Vγ3+,CCR6− did not change appreciably...
A subset of CC chemokine receptor-6(+) (CCR6(+)), γδ-low (GDL) T cells that express Th17 cytokines in mouse skin participates IL-23-induced psoriasiform dermatitis. We use CCR6-deficient (knockout, KO) and wild-type (WT) mice to analyze trafficking patterns GDL function-blocking mAbs determine the role CCR6 IL-23-mediated Herein, CCL20 was highly upregulated IL-23-injected WT ear as early 24 hours after initial treatment, large numbers CCR6(+) were observed epidermis mice. Anti-CCL20 reduced...
ObjectiveTo report the efficacy and safety of approved ixekizumab (IXE) dose over 5 years from UNCOVER-3 (NCT01646177).MethodsPatients (N = 1346) were randomized 1:2:2:2 to receive subcutaneous injections placebo, etanercept 50 mg twice weekly, or IXE 80 every 2 weeks 4 after an initial 160 mg, respectively. At week 12, patients entered long-term extension period with dosing could escalate 60. Efficacy was reported for weeks/every group intent-to-treat population. Safety who received at...
Abstract Background Erythrodermic and generalized pustular psoriasis are rare, difficult to treat forms of psoriasis. In previous reports, we documented 24‐ 52‐week findings an open‐label, phase 3 trial ( UNCOVER ‐J) ixekizumab in Japanese patients with erythrodermic or psoriasis; most responded treatment maintained response through 52 weeks. Objective To assess the long‐term (>3 years) efficacy safety Methods These subgroup analyses were a partial population from ‐J NCT 01624233;...
This is the English version of Japanese guidance for use biologics psoriasis (the 2022 version). As first in Japan, infliximab and adalimumab, anti-tumor necrosis factor-α antibodies, became available field dermatology 2010, followed by ustekinumab, an anti-interleukin (IL)-12/IL-23p40 antibody, which was launched Japan 2011. Moreover, after 2015, three IL-17 inhibitors, IL-17A antibody preparations secukinumab ixekizumab, anti-IL-17 receptor preparation brodalumab were marketed....
Abstract Although many epidemiological surveys for patients with psoriasis have been reported based on individual countries or facilities, there has no study encompassing the major region in Asia. The Asian Society Psoriasis (ASP) conducting an across various and regions to elucidate compare epidemiology of psoriasis. A total 1948 cases were analyzed, 938 from Japan, 530 China, 325 Korea, 141 Chinese Taipei, 14 Thailand, all which enrolled between 2020 2022. In total, male–female ratio was...
Phaeohyphomycosis is a rare subcutaneous fungal infection caused by melanin-containing brown-pigmented fungi. It typically occurs after skin injury in immunocompromised individuals. Herein, we report case of phaeohyphomycosis Exophiala xenobiotica an elderly Japanese female. A mass on her left lower leg was totally removed but reappeared two months later. The resolved with additional seven 200 mg/day oral itraconazole treatment. E. identified as new black yeast species 2006. Genetic...
Localization of each keratin isoform differs among epidermal layers. Proliferating basal cells synthesize 14 (K14) and suprabasal express 10 (K10) in normal skin. Notch signaling is essential for keratinocyte differentiation. Notch1 expressed all layers, Notch2 the cell layer Notch3 spinous layers epidermis. It has been poorly elucidated how localization expression levels molecules are related to molecular markers K10 K14 psoriatic skin with abnormal differentiation tissue. This study aimed...
Plaque psoriasis significantly affects patients' health-related quality of life. To aid treatment decisions, not only objective assessment by physicians but also subjective patients is important.To assess the significance Dermatology Life Quality Index (DLQI) evaluation at time biologics introduction in clinical practice Japanese with plaque psoriasis.This was a single-arm, open-label, multicenter study. At baseline, Psoriasis Area and Severity (PASI) DLQI scores were measured stratified...
Abstract Psoriasis is thought to be a multifactorial disease triggered by both genetic and environmental factors. The HLA ‐C locus on chromosome 6p21.33 remains the strongest susceptibility candidate in psoriasis. strong association between psoriasis ‐Cw6 allele has been well documented various races. It known that psoriatic patients with early onset are more likely familial associated . Familial occurrence of Japanese smaller than other populations. Furthermore, males predominant over...
Background A quantitative understanding of the histological alteration skin is important for assessing severity photoaging. Methods We performed Elastica‐van Gieson staining and immunohistochemistry decorin on 34 facial sections. evaluated collagen fibers (a modulator fibrillogenesis), according to 5 grades morphological change in elastic that was established by Kligman (1969). The objectivity a stage (Stages I–VI), which this study, using weighted kappa statistical analysis based degree...
Evidence on treatment effectiveness in patients with psoriasis having anxiety or depressive symptoms helps shared decision-making. This single-arm, open-label, prospective study-ProLOGUE-was conducted to assess the of brodalumab self-assessed and Japanese psoriasis.Patients aged ≥ 18 years plaque without peripheral arthritis who had responded inadequately current therapies were enrolled at 15 facilities received 210 mg subcutaneously.A total 73 (male, 82%; median age, 54 years). The...
Abstract Psoriatic arthritis (PsA), a chronic inflammatory arthropathy associated with psoriasis, is an intractable immune disorder and refractory to pharmacological intervention. We assessed efficacy of selective depletion myeloid lineage leukocytes in patients PsA multicenter setting. A total 20 moderate severe conventional biological disease‐modifying antirheumatic drugs were included. Eligible had 3 points or more the classification criteria for PsA. Each patient received five sessions,...